metronidazole has been researched along with Respiratory Tract Infections in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A controlled, randomized trial with blind assessment of end points is described comparing ceftriaxone (1 g) given at induction of anesthesia with gentamicin (2 mg/kg) and metronidazole (500 mg) (GM), three times, every eight hours starting at induction, in preventing wound, chest, and urinary tract infections following bowel operations." | 9.07 | Ceftriaxone is more effective than gentamicin/metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Results of a controlled, randomized, blind clinical trial. ( Morris, WT, 1993) |
| "A controlled, randomized trial with blind assessment of end points is described comparing ceftriaxone (1 g) given at induction of anesthesia with gentamicin (2 mg/kg) and metronidazole (500 mg) (GM), three times, every eight hours starting at induction, in preventing wound, chest, and urinary tract infections following bowel operations." | 5.07 | Ceftriaxone is more effective than gentamicin/metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Results of a controlled, randomized, blind clinical trial. ( Morris, WT, 1993) |
| "Periorbital cellulitis is a potential sight-threatening complication of sinusitis." | 2.94 | The management of periorbital cellulitis secondary to sinonasal infection: a multicenter prospective study in the United Kingdom. ( Al-Lami, A; Grounds, R; Hone, R; Hopkins, C; Lloyd, G; Mahalingam, S; Pervez, A; Poon, JS; Riley, P; Rudd, J; Shamil, E; Wong, G, 2020) |
| "During the study period (6 months) upper respiratory tract infections (URTI) were the commonest illness in all groups; there were significantly more gastroenteric infections in the group given the supplement, but not the antibiotic, treatment; the children who received only the standard health service care were ill more often and for longer periods than children in the other groups." | 2.67 | The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth. ( Christie, CD; Dawson, S; Gernay, J; Heikens, GT; Schofield, WN, 1993) |
| "Metronidazole was the most active agent against all isolates." | 1.56 | Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait. ( AlAzmi, A; AlHashem, G; Jamal, W; Khodakhast, FB; Rotimi, VO; Sόki, J, 2020) |
| "Metronidazole was always used in combination with other antimicrobial drugs." | 1.28 | Clinical use of metronidazole in horses: 200 cases (1984-1989). ( Sweeney, CR; Sweeney, RW; Weiher, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Jamal, W | 1 |
| Khodakhast, FB | 1 |
| AlAzmi, A | 1 |
| Sόki, J | 1 |
| AlHashem, G | 1 |
| Rotimi, VO | 1 |
| Mahalingam, S | 1 |
| Hone, R | 1 |
| Lloyd, G | 1 |
| Grounds, R | 1 |
| Shamil, E | 1 |
| Wong, G | 1 |
| Al-Lami, A | 1 |
| Pervez, A | 1 |
| Rudd, J | 1 |
| Poon, JS | 1 |
| Riley, P | 1 |
| Hopkins, C | 1 |
| Lanyero, H | 1 |
| Eriksen, J | 1 |
| Obua, C | 1 |
| Stålsby Lundborg, C | 1 |
| Nanzigu, S | 1 |
| Katureebe, A | 1 |
| Kalyango, JN | 1 |
| Ocan, M | 1 |
| Kinoshita, Y | 1 |
| Niwa, H | 1 |
| Katayama, Y | 1 |
| Hariu, K | 1 |
| Boyanova, L | 1 |
| Ilieva, J | 1 |
| Gergova, G | 1 |
| Davidkov, L | 1 |
| Spassova, Z | 1 |
| Kamburov, V | 1 |
| Katsarov, N | 1 |
| Mitov, I | 1 |
| Flenley, DC | 1 |
| Morris, WT | 1 |
| Heikens, GT | 1 |
| Schofield, WN | 1 |
| Christie, CD | 1 |
| Gernay, J | 1 |
| Dawson, S | 1 |
| Ruol, A | 1 |
| Bertiato, G | 1 |
| Boscarin, S | 1 |
| Cusinato, R | 1 |
| Pascarella, M | 1 |
| Tonin, EA | 1 |
| Santi, S | 1 |
| Ancona, E | 1 |
| Sprott, MS | 1 |
| Ingham, HR | 1 |
| O'Grady, LR | 1 |
| Ralph, ED | 1 |
| Füllner, G | 1 |
| Müller, W | 1 |
| Tetteroo, GW | 1 |
| Wagenvoort, JH | 1 |
| Castelein, A | 1 |
| Tilanus, HW | 1 |
| Ince, C | 1 |
| Bruining, HA | 1 |
| Sweeney, RW | 1 |
| Sweeney, CR | 1 |
| Weiher, J | 1 |
| Morton, RP | 1 |
| Mellow, CG | 1 |
| Dorman, EB | 1 |
| Briedigkeit, H | 1 |
| Walker, AN | 1 |
| James, DG | 1 |
| Bailey, AR | 1 |
| Brunt, ME | 1 |
| Diddle, AW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276] | Phase 2 | 81 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition[NCT03174236] | Phase 3 | 2,000 participants (Anticipated) | Interventional | 2017-09-04 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Respiratory Tract Infections
| Article | Year |
|---|---|
New drugs in respiratory disorders: II.
Topics: Adult; Aged; Amantadine; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cephalosporins; | 1983 |
5 trials available for metronidazole and Respiratory Tract Infections
| Article | Year |
|---|---|
The management of periorbital cellulitis secondary to sinonasal infection: a multicenter prospective study in the United Kingdom.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Cellulitis; Child; Drug Therapy, Combination; Humans; Len | 2020 |
Ceftriaxone is more effective than gentamicin/metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Results of a controlled, randomized, blind clinical trial.
Topics: Aged; Aged, 80 and over; Bacteria; Ceftriaxone; Drug Therapy, Combination; Female; Gentamicins; Huma | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
Selective decontamination to reduce gram-negative colonisation and infections after oesophageal resection.
Topics: Adult; Aged; Cefotaxime; Chi-Square Distribution; Cross Infection; Drug Administration Schedule; Dru | 1990 |
Chest infection following head and neck surgery: a pilot study.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Clavulanic Acids; Drug Thera | 1990 |
12 other studies available for metronidazole and Respiratory Tract Infections
| Article | Year |
|---|---|
Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacterial Toxins; Bacteroides | 2020 |
Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants.
Topics: Amoxicillin; Anti-Bacterial Agents; Child, Preschool; Cough; Cross-Sectional Studies; Female; Health | 2020 |
Dominant obligate anaerobes revealed in lower respiratory tract infection in horses by 16S rRNA gene sequencing.
Topics: Animals; Anti-Infective Agents; Bacteria, Anaerobic; Bacteroides; Base Sequence; Bronchoalveolar Lav | 2014 |
Numerous risk factors for Helicobacter pylori antibiotic resistance revealed by extended anamnesis: a Bulgarian study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bulgaria; Clarithromycin; Coinfec | 2012 |
Short-Term prophylaxis with ceftriaxone plus metronidazole in esophageal cancer surgery.
Topics: Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Bacteriuria; Ceftriaxone; Drug Administratio | 2000 |
Treatment of infections due to nonsporing anaerobes.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Brain Diseases; Cefoxitin; Clindamycin; G | 1979 |
Anaerobic meningitis and bacteremia caused by Fusobacterium species.
Topics: Adolescent; Child, Preschool; Chloramphenicol; Diagnosis, Differential; Female; Fusobacterium; Human | 1976 |
[The therapy of swimbladder inflammation (renicola sphaerosporosis) of carp].
Topics: Air Sacs; Animals; Antiprotozoal Agents; Carps; Cyclohexanes; Fatty Acids, Unsaturated; Fish Disease | 1992 |
Clinical use of metronidazole in horses: 200 cases (1984-1989).
Topics: Animals; Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Drug Therapy, Combinatio | 1991 |
[Therapy and prevention with metronidazole].
Topics: Bacteria, Anaerobic; Bacterial Infections; Female; Genital Diseases, Female; Humans; Metronidazole; | 1985 |
Fresh drugs for old problems.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Azathioprine; Cephalosporins; Humans; Liver Abscess, | 1971 |
Trichomonas vaginalis: resistance to metronidazole.
Topics: Adult; Antiprotozoal Agents; Arsenicals; Borates; Carbohydrates; Ethinyl Estradiol; Female; Humans; | 1967 |