| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
4-phenyl-3-furoxancarbonitrile
4-phenyl-3-furoxancarbonitrile: structure given in first source. 4-phenyl-3-furoxancarbonitrile : A 1,2,5-oxadiazole substituted by an oxido, cyano and phenyl groups at positions 2, 3 and 4, respectively. It is a vasodilator and inhibitor of platelet aggregation. | 3.35 | 1 | 0 | 1,2,5-oxadiazole;
benzenes;
N-oxide;
nitrile | geroprotector;
nitric oxide donor;
platelet aggregation inhibitor;
soluble guanylate cyclase activator;
vasodilator agent |
cgs 15943
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine: non-xanthine triazoloquinazoline adenosine antagonist. CGS 15943 : A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors. | 3.35 | 1 | 0 | aromatic amine;
biaryl;
furans;
organochlorine compound;
primary amino compound;
quinazolines;
triazoloquinazoline | adenosine A1 receptor antagonist;
adenosine A2A receptor antagonist;
antineoplastic agent;
central nervous system stimulant |
cl 387785
CL 387785: structure in first source. N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide : A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group at position 6 has been replaced by a but-2-ynoyl group. | 3.35 | 1 | 0 | bromobenzenes;
quinazolines;
secondary carboxamide;
ynamide | antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
epidermal growth factor receptor antagonist |
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | 2.15 | 1 | 0 | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic |
oxamniquine
Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121). oxamniquine : A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.. {2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol : A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively. | 3.35 | 1 | 0 | aromatic primary alcohol;
C-nitro compound;
quinolines;
secondary amino compound | |
praziquantel
azinox: Russian drug | 3.35 | 1 | 0 | isoquinolines | |
1-hexanol
1-hexanol: RN given refers to parent cpd. hexanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of six carbon atoms.. hexan-1-ol : A primary alcohol that is hexane substituted by a hydroxy group at position 1. | 2.06 | 1 | 0 | hexanol;
primary alcohol | alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite |
lucanthone hydrochloride
Schistosomicides: Agents that act systemically to kill adult schistosomes. | 2.5 | 2 | 0 | | |
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. | 2.79 | 3 | 0 | organic peroxide;
sesquiterpene lactone | antimalarial;
plant metabolite |
mmv665852
MMV665852: an antischistosomal agent | 3.35 | 1 | 0 | | |
gr 127935
GR 127935: a 5-HT 1D receptor antagonist. GR 127935 : A member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid and the anilino group of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration. | 3.35 | 1 | 0 | 1,2,4-oxadiazole;
benzamides;
N-alkylpiperazine;
N-arylpiperazine | |
parthenolide
[no description available] | 3.35 | 1 | 0 | germacranolide | |
speciophylline
speciophylline: RN refers to (3beta,7alpha,19alpha,20alpha)-isomer; from leaves of Mitragyna inermis (Rubiaceae); structure given in first source | 3.51 | 1 | 0 | indolizines | |
erysodine
erysodine: structure given in first source. erysodine : An erythrina alkaloid with formula C18H21NO3 isolated from several erythrina plant species. It is a competitive antagonist of nicotinic acetylcholine receptors and exhibits antiparasitic and insecticidal activities. | 3.51 | 1 | 0 | aromatic ether;
diether;
Erythrina alkaloid;
organic heterotetracyclic compound;
phenols | antiparasitic agent;
nicotinic antagonist;
phytogenic insecticide |
gw 3965
GW 3965: a liver X receptor ligand | 3.35 | 1 | 0 | diarylmethane | |
artenimol
[no description available] | 3.51 | 1 | 0 | | |
cardamonin
cardamonin: found in Zingiberaceae; structure in first source | 3.35 | 1 | 0 | chalcones | |
stattic
[no description available] | 3.35 | 1 | 0 | 1-benzothiophenes;
C-nitro compound;
sulfone | antineoplastic agent;
radiosensitizing agent;
STAT3 inhibitor |
enpiroline
enpiroline: structure | 3.35 | 1 | 0 | | |
rs 17053
[no description available] | 3.35 | 1 | 0 | indoles | |
erysovine
erysovine: antifeedant from Chinese medicinal herb, Erythrina variegata var. orientalis, against maize weevil Sitophilus zeamais; structure in first source | 3.51 | 1 | 0 | | |
erythraline
erythraline: isolated from Erythrina crista-galli; structure in first source | 3.51 | 1 | 0 | alkaloid | |
licochalcone a
licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer | 3.35 | 1 | 0 | chalcones | |
2'-hydroxy-4-methoxychalcone
[no description available] | 3.35 | 1 | 0 | | |
cesium
Cesium: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency. | 2 | 1 | 0 | alkali metal atom | |
aldosterone
dehydrodiisoeugenol: an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages; structure in first source | 3.35 | 1 | 0 | | |
ekb 569
EKB 569: an EGF receptor kinase inhibitor | 3.35 | 1 | 0 | aminoquinoline;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile | protein kinase inhibitor |
ispinesib
[no description available] | 3.35 | 1 | 0 | benzamides | |
disilver oxide
[no description available] | 2 | 1 | 0 | | |
mer nf5003f
stachybotrydial: a pancreatic cholesterol esterase inhibitor; also inhibits fucosyltransferase and sialyltransferase; structure in first source | 3.51 | 1 | 0 | | |
sd-208
[no description available] | 3.35 | 1 | 0 | | |
aculeatin a
aculeatin A: antineoplastic from Amomum aculeatum; structure in first source | 3.51 | 1 | 0 | | |
arterolane
arterolane: a trioxolane with antimalarial activity; structure in first source. arterolane : An oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine. | 3.51 | 1 | 0 | | |
bi 2536
[no description available] | 3.35 | 1 | 0 | | |
oz 439
artefenomel: an antimalarial ozonide; structure in first source | 3.51 | 1 | 0 | | |
rka 182
RKA 182: structure in first source | 3.51 | 1 | 0 | | |
bms-833923
BMS-833923: an Smo inhibitor | 3.35 | 1 | 0 | | |