metronidazole has been researched along with Cellulitis, Pelvic in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether a postoperative 5-day treatment schedule with vaginal metronidazole added to conventional antibiotic prophylaxis with 2 g cefazolin modifies the risk of pelvic cellulitis (PC) and pelvic abscess (PA) after total laparoscopic hysterectomy (TLH)." | 9.69 | Metronidazole for Prevention of Pelvic Cellulitis and Abscess after Laparoscopic Hysterectomy: A Triple-blinded, Randomized, Placebo-controlled Clinical Trial. ( Arango, A; Bastidas, C; Cárdenas, L; Cifuentes, C; De Los Rios, JF; Gallego, DE; Gómez, SM; López, CC; López, JD; Orjuela, J; Silva, JB; Valencia, V; Vásquez-Trespalacios, EM; Villegas-Echeverri, JD; Zambrano, CP, 2023) |
| "To determine whether a postoperative 5-day treatment schedule with vaginal metronidazole added to conventional antibiotic prophylaxis with 2 g cefazolin modifies the risk of pelvic cellulitis (PC) and pelvic abscess (PA) after total laparoscopic hysterectomy (TLH)." | 5.69 | Metronidazole for Prevention of Pelvic Cellulitis and Abscess after Laparoscopic Hysterectomy: A Triple-blinded, Randomized, Placebo-controlled Clinical Trial. ( Arango, A; Bastidas, C; Cárdenas, L; Cifuentes, C; De Los Rios, JF; Gallego, DE; Gómez, SM; López, CC; López, JD; Orjuela, J; Silva, JB; Valencia, V; Vásquez-Trespalacios, EM; Villegas-Echeverri, JD; Zambrano, CP, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| López, CC | 1 |
| Villegas-Echeverri, JD | 1 |
| De Los Rios, JF | 1 |
| Vásquez-Trespalacios, EM | 1 |
| Arango, A | 1 |
| Cifuentes, C | 1 |
| Orjuela, J | 1 |
| Valencia, V | 1 |
| Cárdenas, L | 1 |
| López, JD | 2 |
| Zambrano, CP | 1 |
| Gómez, SM | 1 |
| Bastidas, C | 1 |
| Silva, JB | 1 |
| Gallego, DE | 1 |
1 trial available for metronidazole and Cellulitis, Pelvic
| Article | Year |
|---|---|
Metronidazole for Prevention of Pelvic Cellulitis and Abscess after Laparoscopic Hysterectomy: A Triple-blinded, Randomized, Placebo-controlled Clinical Trial.
Topics: Abscess; Anti-Bacterial Agents; Cefazolin; Double-Blind Method; Female; Humans; Hysterectomy; Laparo | 2023 |