metronidazole has been researched along with Infections, Pseudomonas in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adverse events were reported by 9% of patients in the isepamicin group (16/178) and 10% of patients in the amikacin group (9/89)." | 2.68 | The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections. ( Leal del Rosal, P, 1995) |
| "No cases of MOE in selective IgA deficiency have been reported in literature." | 1.31 | Malignant otitis externa in an infant with selective IgA deficiency: a case report. ( Balraj, A; Job, A; Justus, A; Kirubakaran, CP; Paul, AC, 2001) |
| "Bacterial meningitis is not considered a separate disease entity but a complication of bacteremia and sepsis." | 1.27 | [Chemotherapy of severe bacterial infections in pediatrics]. ( Guggenbichler, JP, 1983) |
| "Metronidazole was least effective in this regard." | 1.27 | Protective role of intestinal flora against infection with Pseudomonas aeruginosa in mice: influence of antibiotics on colonization resistance. ( Casey, SW; Hentges, DJ; Que, JU; Stein, AJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, S | 1 |
| Bagshaw, RJ | 1 |
| Hanson, J | 1 |
| Saleh, MM | 1 |
| Abbas, HA | 1 |
| Askoura, MM | 1 |
| Sayma, M | 1 |
| Walters, HR | 1 |
| Hesford, C | 1 |
| Tariq, Z | 1 |
| Nakhosteen, A | 1 |
| Obinwa, O | 1 |
| Casidy, M | 1 |
| Flynn, J | 1 |
| Hazarika, M | 1 |
| Pai H, V | 1 |
| Khanna, V | 1 |
| Reddy, H | 1 |
| Tilak, K | 1 |
| Chawla, K | 1 |
| Cipriano Souza, R | 1 |
| Vicente, AC | 1 |
| Vieira, VV | 1 |
| Marques, SG | 1 |
| Soares, Md | 1 |
| Moura, MC | 1 |
| Koifman, RJ | 1 |
| Tuduri, I | 1 |
| Harji, DP | 1 |
| Rastall, S | 1 |
| Catchpole, C | 1 |
| Bright-Thomas, R | 1 |
| Thrush, S | 1 |
| Hocquet, D | 1 |
| Llanes, C | 1 |
| Thouverez, M | 1 |
| Kulasekara, HD | 1 |
| Bertrand, X | 1 |
| Plésiat, P | 1 |
| Mazel, D | 1 |
| Miller, SI | 1 |
| Nandhakumar, B | 1 |
| Menon, T | 1 |
| Ravishankar, G | 1 |
| Shanmugasundaram, S | 1 |
| Hares, MM | 1 |
| Downing, R | 1 |
| Marsh, J | 1 |
| Guggenbichler, JP | 1 |
| Baradnay, G | 1 |
| Nagy, A | 1 |
| Kyle, P | 1 |
| Turner, DP | 1 |
| Leal del Rosal, P | 1 |
| Cade, A | 1 |
| Denton, M | 1 |
| Brownlee, KG | 1 |
| Todd, N | 1 |
| Conway, SP | 1 |
| Feldman, DP | 1 |
| Picerno, NA | 1 |
| Porubsky, ES | 1 |
| Paul, AC | 1 |
| Justus, A | 1 |
| Balraj, A | 1 |
| Job, A | 1 |
| Kirubakaran, CP | 1 |
| West, SD | 1 |
| Brunskill, NJ | 1 |
| Shibuya, M | 1 |
| Yanabe, M | 1 |
| Osugi, N | 1 |
| Tanaka, T | 1 |
| Hentges, DJ | 1 |
| Stein, AJ | 1 |
| Casey, SW | 1 |
| Que, JU | 1 |
| Brook, I | 1 |
| Walker, RI | 1 |
1 review available for metronidazole and Infections, Pseudomonas
| Article | Year |
|---|---|
Pseudomonal breast infection.
Topics: Abscess; Anti-Bacterial Agents; Ciprofloxacin; Drug Therapy, Combination; Female; Humans; Mastitis; | 2010 |
2 trials available for metronidazole and Infections, Pseudomonas
| Article | Year |
|---|---|
Failure of metronidazole/penicillin oral prophylaxis to prevent amputation stump infection.
Topics: Administration, Oral; Amputation, Surgical; Clinical Trials as Topic; Humans; Metronidazole; Neomyci | 1980 |
The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Cholecystitis; Drug Administration Schedule; Escherichia col | 1995 |
19 other studies available for metronidazole and Infections, Pseudomonas
| Article | Year |
|---|---|
The microbiology of crocodile attacks in Far North Queensland: implications for empirical antimicrobial therapy.
Topics: Adolescent; Adult; Aged; Alligators and Crocodiles; Animals; Anti-Bacterial Agents; Bacillus cereus; | 2017 |
Repositioning secnidazole as a novel virulence factors attenuating agent in Pseudomonas aeruginosa.
Topics: Animals; Anti-Infective Agents; Disease Models, Animal; Drug Repositioning; Gene Expression Profilin | 2019 |
Rapidly enlarging, giant hepatic cyst growing pseudomonas.
Topics: Aged; Anti-Bacterial Agents; Cardiac Output, Low; Cysts; Drainage; Dyspnea; Female; Humans; Liver Di | 2019 |
The microbiology of bacterial peritonitis due to appendicitis in children.
Topics: Adolescent; Aminoglycosides; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; A | 2014 |
Rare Case of Polymicrobial Keratitis With Balantidium coli.
Topics: Anti-Bacterial Agents; Antiprotozoal Agents; Balantidiasis; Balantidium; Coinfection; Contact Lenses | 2016 |
Clindamycin and metronidazole as independent risk factors for nosocomial acquisition of multidrug-resistant Pseudomonas aeruginosa.
Topics: Anti-Bacterial Agents; Clindamycin; Cross Infection; Drug Resistance, Multiple, Bacterial; Humans; M | 2008 |
Considerations about the article by St. Peter "Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomised trial". J Pediatr Surg 2008;43:981-985.
Topics: Abdominal Abscess; Appendicitis; Cefoxitin; Ceftriaxone; Cefuroxime; Child; Community-Acquired Infec | 2008 |
Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.
Topics: Adaptation, Physiological; Adult; Anti-Bacterial Agents; beta-Lactamases; Ceftazidime; Drug Resistan | 2012 |
Pacemaker pocket infection associated with septicemia caused by Pseudomonas aeruginosa.
Topics: Adult; Anti-Bacterial Agents; Cardiac Surgical Procedures; Cardiomyopathy, Hypertrophic; Cefoperazon | 2008 |
[Chemotherapy of severe bacterial infections in pediatrics].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Cephalosporins; Clindamyci | 1983 |
Modern trends in colorectal surgery.
Topics: Anti-Bacterial Agents; Colectomy; Colonic Neoplasms; Enterobacteriaceae Infections; Female; Humans; | 1983 |
Chorioamnionitis due to pseudomonas aeruginosa: a complication of prolonged antibiotic therapy for premature rupture of membranes.
Topics: Adult; Cephalexin; Chorioamnionitis; Drug Therapy, Combination; Female; Fetal Membranes, Premature R | 1996 |
Acute bronchopulmonary infection due to Streptococcus milleri in a child with cystic fibrosis.
Topics: Acute Disease; Child; Colistin; Cystic Fibrosis; Drug Therapy, Combination; Female; Floxacillin; Hum | 1999 |
Cavernous sinus thrombosis complicating odontogenic parapharyngeal space neck abscess: a case report and discussion.
Topics: Aged; Anti-Infective Agents; Cavernous Sinus Thrombosis; Ceftriaxone; Cephalosporins; Combined Modal | 2000 |
Malignant otitis externa in an infant with selective IgA deficiency: a case report.
Topics: Child, Preschool; Ciprofloxacin; Cloxacillin; Combined Modality Therapy; Debridement; Drug Therapy, | 2001 |
Complications associated with influenza infection.
Topics: Acute Kidney Injury; Alphainfluenzavirus; Drug Therapy, Combination; Humans; Imipenem; Influenza, Hu | 2002 |
[A trial designed to obtain a specific pathogen free Syrian hamster colony by administration of chemicals].
Topics: Animals; Breeding; Cricetinae; Female; Male; Mesocricetus; Metronidazole; Netilmicin; Pasteurella In | 1992 |
Protective role of intestinal flora against infection with Pseudomonas aeruginosa in mice: influence of antibiotics on colonization resistance.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Clindamycin; Clostridium perfringens; Immunity, Innate; | 1985 |
The relationship between Fusobacterium species and other flora in mixed infection.
Topics: Abscess; Animals; Bacteroides Infections; Escherichia coli Infections; Fusobacterium; Fusobacterium | 1986 |