metronidazole has been researched along with Equine Diseases in 32 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole appeared to be an effective treatment; eight horses treated with metronidazole survived whereas five of seven horses that received other treatments, but no metronidazole, died or had to be euthanased." | 5.30 | Use of metronidazole in equine acute idiopathic toxaemic colitis. ( Dixon, PM; McGorum, BC; Smith, DG, 1998) |
| "Metronidazole appeared to be an effective treatment; eight horses treated with metronidazole survived whereas five of seven horses that received other treatments, but no metronidazole, died or had to be euthanased." | 1.30 | Use of metronidazole in equine acute idiopathic toxaemic colitis. ( Dixon, PM; McGorum, BC; Smith, DG, 1998) |
| "Lactose intolerance is a secondary problem most commonly associated with rotavirus infection, but it can be caused by any condition affecting the small intestine." | 1.30 | Association of Clostridium difficile with enterocolitis and lactose intolerance in a foal. ( Parsons, DA; Staempfli, HR; Weese, JS, 1999) |
| "23 h-1, and the mean elimination half-life (t1/2) was 3." | 1.28 | Pharmacokinetics of metronidazole and its concentration in body fluids and endometrial tissues of mares. ( Brown, MP; Gronwall, RR; Houston, AE; Rib, WJ; Specht, TE, 1992) |
| "Metronidazole was always used in combination with other antimicrobial drugs." | 1.28 | Clinical use of metronidazole in horses: 200 cases (1984-1989). ( Sweeney, CR; Sweeney, RW; Weiher, J, 1991) |
| "Anaerobic bacterial pneumonia with septicemia was diagnosed in 2 Thoroughbred racehorses referred with respiratory tract disease that had failed to respond to initial treatment with various antibiotics including penicillin and trimethoprim-sulfamethoxazole." | 1.28 | Anaerobic bacterial pneumonia with septicemia in two racehorses. ( Carlson, GP; O'Brien, MA, 1990) |
| " The route of administration, size of the dose and dosing interval must be appropriate for the drug preparation selected." | 1.27 | Antimicrobial selection and dosage in the treatment of equine bacterial infections. ( Baggot, JD; Prescott, JF, 1987) |
| "Giardia infection was believed responsible for chronic diarrhea, weight loss, lethargy, inappetence, and dermatitis in a 4-year-old Thoroughbred horse." | 1.27 | Giardiasis in a horse. ( Kirkpatrick, CE; Skand, DL, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (18.75) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Kinoshita, Y | 2 |
| Niwa, H | 2 |
| Uchida-Fujii, E | 1 |
| Nukada, T | 1 |
| Ueno, T | 1 |
| Caol, S | 1 |
| Divers, T | 1 |
| Crisman, M | 1 |
| Chang, YF | 1 |
| Katayama, Y | 1 |
| Hariu, K | 1 |
| Magdesian, KG | 2 |
| Hirsh, DC | 2 |
| Jang, SS | 2 |
| Hansen, LM | 2 |
| Madigan, JE | 2 |
| Weese, JS | 2 |
| Cote, NM | 1 |
| deGannes, RV | 1 |
| Dujowich, M | 1 |
| Barr, BS | 1 |
| Mogg, TD | 3 |
| Rutherford, DJ | 1 |
| Stewart, AJ | 2 |
| Dykgraaf, S | 1 |
| Hart, J | 1 |
| Wearn, J | 1 |
| Magid, JH | 1 |
| Rohner, K | 1 |
| Demuth, D | 1 |
| Dechan, J | 1 |
| Dechant, JE | 1 |
| MacDonald, DG | 1 |
| Crawford, WH | 1 |
| O'Connor, BP | 1 |
| McGorum, BC | 1 |
| Dixon, PM | 1 |
| Smith, DG | 1 |
| Dyson, SJ | 1 |
| Jones, RD | 1 |
| Ricketts, SW | 1 |
| Sanford, J | 1 |
| Rutter, JM | 1 |
| Nind, F | 1 |
| Taylor, PM | 1 |
| Parsons, DA | 1 |
| Staempfli, HR | 1 |
| Jones, RL | 1 |
| Specht, TE | 1 |
| Brown, MP | 1 |
| Gronwall, RR | 1 |
| Rib, WJ | 1 |
| Houston, AE | 1 |
| Sweeney, RW | 1 |
| Sweeney, CR | 1 |
| Weiher, J | 1 |
| Carlson, GP | 1 |
| O'Brien, MA | 1 |
| Baggot, JD | 1 |
| Prescott, JF | 1 |
| Mair, TS | 1 |
| Yeo, SP | 1 |
| Kirkpatrick, CE | 1 |
| Skand, DL | 1 |
| Owen, RR | 1 |
| Jagger, DW | 1 |
| Quan-Taylor, R | 1 |
| Grant, SA | 1 |
| Walker, AC | 1 |
| Grant, PM | 1 |
1 review available for metronidazole and Equine Diseases
| Article | Year |
|---|---|
Clostridial enterocolitis.
Topics: Animals; Bacitracin; Clostridioides difficile; Clostridium Infections; Clostridium perfringens; Dise | 2000 |
31 other studies available for metronidazole and Equine Diseases
| Article | Year |
|---|---|
Simultaneous Daily Fecal Microbiota Transplantation Fails to Prevent Metronidazole-Induced Dysbiosis of Equine Gut Microbiota.
Topics: Animals; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Horse Dise | 2022 |
In vitro susceptibility of Borrelia burgdorferi isolates to three antibiotics commonly used for treating equine Lyme disease.
Topics: Animals; Anti-Bacterial Agents; Borrelia burgdorferi; Cephalosporins; Horse Diseases; Horses; Lyme D | 2017 |
Dominant obligate anaerobes revealed in lower respiratory tract infection in horses by 16S rRNA gene sequencing.
Topics: Animals; Anti-Infective Agents; Bacteria, Anaerobic; Bacteroides; Base Sequence; Bronchoalveolar Lav | 2014 |
Characterization of Clostridium difficile isolates from foals with diarrhea: 28 cases (1993-1997).
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Clos | 2002 |
Evaluation of in vitro properties of di-tri-octahedral smectite on clostridial toxins and growth.
Topics: Animals; Anti-Infective Agents; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Clos | 2003 |
Molecular characterization of Clostridium difficile isolates from horses in an intensive care unit and association of disease severity with strain type.
Topics: Animals; Anti-Bacterial Agents; Bacterial Toxins; Base Sequence; Clostridioides difficile; Drug Resi | 2006 |
Infiltrative intestinal disease.
Topics: Abdomen; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Clioquinol; Dexamethasone; Diagno | 2006 |
Intra-abdominal abscess and peritonitis in an Appaloosa gelding.
Topics: Abdominal Abscess; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Gentamic | 2006 |
Actinobacillus pleuritis and peritonitis in a quarter horse mare.
Topics: Actinobacillus; Actinobacillus Infections; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, | 2006 |
Actinobacillus peritonitis in a Warmblood gelding.
Topics: Actinobacillus; Actinobacillus Infections; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, | 2006 |
Postpartum hemoperitoneum and septic peritonitis in a Thoroughbred mare.
Topics: Abdominal Cavity; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; | 2006 |
Clostridial myositis and collapse in a standardbred filly.
Topics: Abscess; Analgesics; Animals; Anti-Infective Agents; Blood Cell Count; Blood Chemical Analysis; Buto | 2006 |
Pneumonia and pleuritis in a mare.
Topics: Animals; Anti-Infective Agents; Blood Cell Count; Blood Chemical Analysis; Blood Gas Analysis; Cepha | 2006 |
[Adverse effects of veterinary drugs].
Topics: Animals; Anti-Infective Agents; Cat Diseases; Cats; Dipyrone; Dog Diseases; Dogs; Drug Combinations; | 1994 |
Combination of medical and surgical therapy for pleuropneumonia in a horse.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antitrichomonal Agents; Cep | 1997 |
Pleuritis associated with perforation of an isolated oesophageal ulcer in a horse.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Clinical Chemistry Tests; C | 1998 |
Use of metronidazole in equine acute idiopathic toxaemic colitis.
Topics: Animals; Anti-Bacterial Agents; Colitis; Female; Horse Diseases; Horses; Male; Metronidazole | 1998 |
Use of metronidazole in horses.
Topics: Animal Welfare; Animals; Antitrichomonal Agents; England; Food Contamination; Horse Diseases; Horses | 1998 |
Use of metronidazole in horses.
Topics: Animals; Antitrichomonal Agents; Europe; Food Contamination; Horse Diseases; Horses; Metronidazole; | 1998 |
Use of metronidazole in horses.
Topics: Animals; Antitrichomonal Agents; Horse Diseases; Horses; Metronidazole; Public Health; Public Policy | 1998 |
Use of metronidazole in horses.
Topics: Animals; Horse Diseases; Horses; Legislation, Veterinary; Metronidazole; United Kingdom | 1998 |
Association of Clostridium difficile with enterocolitis and lactose intolerance in a foal.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; beta-Galactosidase; Clostridioides difficile; Clos | 1999 |
Pharmacokinetics of metronidazole and its concentration in body fluids and endometrial tissues of mares.
Topics: Administration, Oral; Animals; Endometrium; Female; Horse Diseases; Horses; Infusions, Intravenous; | 1992 |
Clinical use of metronidazole in horses: 200 cases (1984-1989).
Topics: Animals; Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Drug Therapy, Combinatio | 1991 |
Anaerobic bacterial pneumonia with septicemia in two racehorses.
Topics: Animals; Bacteria, Anaerobic; Bacteroides; Female; Fusobacterium necrophorum; Horse Diseases; Horses | 1990 |
Antimicrobial selection and dosage in the treatment of equine bacterial infections.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Horse | 1987 |
Equine pleuropneumonia: the importance of anaerobic bacteria and the potential value of metronidazole in treatment.
Topics: Animals; Bacteria, Anaerobic; Bacterial Infections; Horse Diseases; Horses; Male; Metronidazole; Ple | 1987 |
Giardiasis in a horse.
Topics: Animals; Dermatitis; Diarrhea; Giardiasis; Horse Diseases; Horses; Male; Metronidazole | 1985 |
Possible adverse reaction to metronidazole in the horse.
Topics: Animals; Horse Diseases; Horses; Metronidazole; Paralysis | 1985 |
Possible adverse reaction to metronidazole in the horse.
Topics: Animals; Horse Diseases; Horses; Metronidazole | 1985 |
Possible adverse reaction to metronidazole.
Topics: Animals; Female; Horse Diseases; Horses; Injections, Intraperitoneal; Metronidazole | 1985 |