DNA-binding transcription activator activity, RNA polymerase II-specific

Definition

Target type: molecularfunction

A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]

DNA-binding transcription activator activity, RNA polymerase II-specific, is a molecular function that describes the ability of a protein to bind to DNA and activate the transcription of genes by RNA polymerase II. This process is essential for gene expression and is involved in a wide range of cellular processes, including cell growth, development, and response to environmental stimuli.

Proteins with this activity typically contain a DNA-binding domain, which allows them to recognize and bind to specific DNA sequences, and a transcription activation domain, which interacts with other proteins involved in the transcription process. The DNA-binding domain often recognizes specific DNA sequences known as enhancers or promoters, which are located upstream or downstream of the genes they regulate.

Once bound to DNA, these transcription activators recruit RNA polymerase II and other transcription factors to the promoter, forming a pre-initiation complex. This complex initiates the transcription process, leading to the synthesis of mRNA from the DNA template.

The specific mechanism by which transcription activators activate transcription can vary depending on the protein. Some activators may directly interact with RNA polymerase II, while others may recruit coactivators that facilitate the assembly of the pre-initiation complex.

Overall, DNA-binding transcription activator activity, RNA polymerase II-specific, is a critical molecular function that plays a central role in regulating gene expression. This activity is essential for normal cellular function and is involved in a wide range of physiological processes.'
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Proteins (56)

Compounds (2,435)