metronidazole has been researched along with Periapical Periodontitis in 29 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Periapical Periodontitis: Inflammation of the PERIAPICAL TISSUE. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is PERIAPICAL GRANULOMA. Suppurative inflammation is PERIAPICAL ABSCESS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis." | 9.10 | [The observation of the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis]. ( Kong, L; Wang, D; Wang, ZP; Zhang, LJ, 2003) |
| "Among the components of the triple antibiotic paste, only minocycline caused the tooth discoloration." | 5.14 | Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. ( Jung, IY; Kim, JH; Kim, Y; Park, JW; Shin, SJ, 2010) |
| "To observe the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis." | 5.10 | [The observation of the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis]. ( Kong, L; Wang, D; Wang, ZP; Zhang, LJ, 2003) |
| "The objective of this study is to compare effects of formocresol, camphorated phenol and Ya Kan (metronedazole) on endotoxin levels in canals of chronic periapical periodontitis." | 3.71 | [Effects of different disinfectants on levels of endotoxin in canals of chronic periapical periodontitis]. ( Hu, T; Tan, H; Xu, Y, 2001) |
| "Subsequently, #8 developed pulp necrosis and an acute apical abscess and #7 symptomatic apical periodontitis." | 1.40 | Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy. ( Lin, LM; Ricucci, D; Rosenberg, PA; Saoud, TM; Sigurdsson, A, 2014) |
| "Apical periodontitis was induced in 20 upper and lower premolars of 2 dogs." | 1.39 | Histologic characterization of engineered tissues in the canal space of closed-apex teeth with apical periodontitis. ( Cintra, LT; Dezan, E; Duarte, PC; Ervolino, E; Gomes-Filho, JE; Lodi, CS; Mogami Bomfim, SR; Mota da Silva Santos, L; Penha De Oliveira, SH; Xavier Abimussi, CJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 14 (48.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alagl, A | 1 |
| Bedi, S | 1 |
| Hassan, K | 1 |
| AlHumaid, J | 1 |
| Arruda, MEF | 1 |
| Neves, MAS | 1 |
| Diogenes, A | 1 |
| Mdala, I | 1 |
| Guilherme, BPS | 1 |
| Siqueira, JF | 1 |
| Rôças, IN | 1 |
| Gomes-Filho, JE | 1 |
| Duarte, PC | 1 |
| Ervolino, E | 1 |
| Mogami Bomfim, SR | 1 |
| Xavier Abimussi, CJ | 1 |
| Mota da Silva Santos, L | 1 |
| Lodi, CS | 1 |
| Penha De Oliveira, SH | 1 |
| Dezan, E | 1 |
| Cintra, LT | 1 |
| Scarparo, RK | 3 |
| Dondoni, L | 3 |
| Böttcher, DE | 3 |
| Grecca, FS | 3 |
| Figueiredo, JA | 2 |
| Kantarci, A | 1 |
| Van Dyke, TE | 1 |
| Batista, EL | 3 |
| Zhang, DD | 1 |
| Chen, X | 1 |
| Bao, ZF | 1 |
| Chen, M | 1 |
| Ding, ZJ | 1 |
| Zhong, M | 1 |
| Saoud, TM | 1 |
| Sigurdsson, A | 2 |
| Rosenberg, PA | 1 |
| Lin, LM | 1 |
| Ricucci, D | 1 |
| Stambolsky, C | 1 |
| Rodríguez-Benítez, S | 1 |
| Gutiérrez-Pérez, JL | 1 |
| Torres-Lagares, D | 1 |
| Martín-González, J | 1 |
| Segura-Egea, JJ | 1 |
| Jung, IY | 3 |
| Lee, SJ | 2 |
| Hargreaves, KM | 2 |
| Reynolds, K | 1 |
| Johnson, JD | 2 |
| Cohenca, N | 2 |
| Ding, RY | 1 |
| Cheung, GS | 1 |
| Chen, J | 1 |
| Yin, XZ | 1 |
| Wang, QQ | 1 |
| Zhang, CF | 1 |
| Akgun, OM | 1 |
| Altun, C | 1 |
| Guven, G | 1 |
| da Silva, LA | 1 |
| Nelson-Filho, P | 1 |
| da Silva, RA | 1 |
| Flores, DS | 1 |
| Heilborn, C | 1 |
| Kim, JH | 1 |
| Kim, Y | 1 |
| Shin, SJ | 1 |
| Park, JW | 1 |
| Nosrat, A | 1 |
| Seifi, A | 1 |
| Asgary, S | 1 |
| Rockenbach, MI | 1 |
| Kottoor, J | 1 |
| Velmurugan, N | 1 |
| Tan, H | 1 |
| Hu, T | 1 |
| Xu, Y | 1 |
| Wang, ZP | 1 |
| Wang, D | 1 |
| Zhang, LJ | 1 |
| Kong, L | 1 |
| Windley, W | 1 |
| Teixeira, F | 1 |
| Levin, L | 1 |
| Trope, M | 1 |
| Sagan, C | 1 |
| Salvador, A | 1 |
| Dubreuil, D | 1 |
| Poulet, PP | 1 |
| Duffaut, D | 1 |
| Brumpt, I | 1 |
| Brescó-Salinas, M | 1 |
| Costa-Riu, N | 1 |
| Berini-Aytés, L | 1 |
| Gay-Escoda, C | 1 |
| Koch, F | 1 |
| Breil, P | 1 |
| Marroquín, BB | 1 |
| Gawehn, J | 1 |
| Kunkel, M | 1 |
| LeCorn, DW | 1 |
| Vertucci, FJ | 1 |
| Rojas, MF | 1 |
| Progulske-Fox, A | 1 |
| Bélanger, M | 1 |
| Iwaya, SI | 1 |
| Ikawa, M | 1 |
| Kubota, M | 1 |
| Hess, JC | 1 |
| Bánóczy, J | 1 |
| Nyárasky, I | 1 |
| Ferenczi, I | 1 |
| Maurette, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis: a Multicenter Randomized Controlled Clinical Trial.[NCT04313010] | 346 participants (Anticipated) | Interventional | 2020-03-16 | Recruiting | |||
| Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry (A Randomized Controlled Clinical Trial)[NCT04533074] | Phase 2 | 16 participants (Actual) | Interventional | 2018-08-23 | Terminated (stopped due to due to the COVID-19 pandemic) | ||
| Randomized Controlled Research of Revascularization in Immature Permanent Teeth With Periapical Periodontitis[NCT01799187] | 190 participants (Anticipated) | Interventional | 2012-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Periapical Periodontitis
| Article | Year |
|---|---|
Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial.
Topics: Anti-Bacterial Agents; Apexification; Biocompatible Materials; Calcium; Child; Ciprofloxacin; Dental | 2011 |
Revascularization for a necrotic immature permanent lateral incisor: a case report and literature review.
Topics: Anti-Bacterial Agents; Apexification; Calcium Hydroxide; Child; Ciprofloxacin; Dental Pulp Necrosis; | 2013 |
3 trials available for metronidazole and Periapical Periodontitis
| Article | Year |
|---|---|
Infection Control in Teeth with Apical Periodontitis Using a Triple Antibiotic Solution or Calcium Hydroxide with Chlorhexidine: A Randomized Clinical Trial.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Calcium Hydroxide; Chlorhexidi | 2018 |
Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report.
Topics: Acrylic Resins; Anti-Bacterial Agents; Anti-Infective Agents; Child; Ciprofloxacin; Colorimetry; Den | 2010 |
[The observation of the effect of metronidazole-chlorhexidine solution on treatment of periapical periodontitis].
Topics: Adolescent; Adult; Aged; Chlorhexidine; Female; Humans; Male; Metronidazole; Middle Aged; Periapical | 2003 |
24 other studies available for metronidazole and Periapical Periodontitis
| Article | Year |
|---|---|
Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Bone Density; Calcium Compounds; Cefaclor; Child; Ciprofl | 2017 |
Histologic characterization of engineered tissues in the canal space of closed-apex teeth with apical periodontitis.
Topics: Animals; Anti-Bacterial Agents; Bicuspid; Blood Coagulation; Bone and Bones; Bone Marrow Cells; Cipr | 2013 |
Intracanal delivery of Resolvin E1 controls inflammation in necrotic immature rat teeth.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ciprofloxacin; Dental Pulp Cavity; Dental | 2014 |
Histologic comparison between platelet-rich plasma and blood clot in regenerative endodontic treatment: an animal study.
Topics: Aluminum Compounds; Animals; Apexification; Blood Coagulation; Calcium Compounds; Cementogenesis; Ci | 2014 |
Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy.
Topics: Anti-Bacterial Agents; Apexification; Blood Coagulation; Ciprofloxacin; Dental Pulp Necrosis; Female | 2014 |
Histologic characterization of regenerated tissues after pulp revascularization of immature dog teeth with apical periodontitis using tri-antibiotic paste and platelet-rich plasma.
Topics: Aluminum Compounds; Animals; Bicuspid; Calcium Compounds; Cefixime; Ciprofloxacin; Combined Modality | 2016 |
Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series.
Topics: Adolescent; Anti-Infective Agents, Local; Child; Ciprofloxacin; Dens in Dente; Dental Pulp; Dental P | 2008 |
Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series.
Topics: Adolescent; Anti-Infective Agents, Local; Child; Ciprofloxacin; Dens in Dente; Dental Pulp; Dental P | 2008 |
Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series.
Topics: Adolescent; Anti-Infective Agents, Local; Child; Ciprofloxacin; Dens in Dente; Dental Pulp; Dental P | 2008 |
Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series.
Topics: Adolescent; Anti-Infective Agents, Local; Child; Ciprofloxacin; Dens in Dente; Dental Pulp; Dental P | 2008 |
Pulp revascularization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discolouration: a case report.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bicuspid; Child; Ciprofloxacin; Dental Fistula; Dental | 2009 |
Pulp revascularization of immature teeth with apical periodontitis: a clinical study.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Anti-Infective Agents; Bicuspid; Blood Coagulation; Calci | 2009 |
Use of triple antibiotic paste as a disinfectant for a traumatized immature tooth with a periapical lesion: a case report.
Topics: Anti-Infective Agents, Local; Child; Ciprofloxacin; Drug Combinations; Female; Humans; Incisor; Metr | 2009 |
Revascularization and periapical repair after endodontic treatment using apical negative pressure irrigation versus conventional irrigation plus triantibiotic intracanal dressing in dogs' teeth with apical periodontitis.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Bacterial Agents; Ciprofloxacin; Connective Tiss | 2010 |
Response to intracanal medication in immature teeth with pulp necrosis: an experimental model in rat molars.
Topics: Animals; Anti-Bacterial Agents; Apexification; Cementogenesis; Ciprofloxacin; Dental Pulp Necrosis; | 2011 |
Apical periodontium response to enamel matrix derivative as an intracanal medication in rat immature teeth with pulp necrosis: radiographic and histologic findings.
Topics: Animals; Anti-Bacterial Agents; Cementogenesis; Ciprofloxacin; Dental Cementum; Dental Enamel Protei | 2012 |
Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series.
Topics: Adolescent; Aluminum Compounds; Anti-Bacterial Agents; Apexification; Calcium Compounds; Calcium Hyd | 2012 |
[Effects of different disinfectants on levels of endotoxin in canals of chronic periapical periodontitis].
Topics: Anti-Infective Agents, Local; Bacteria, Aerobic; Camphor; Chronic Disease; Drug Combinations; Endoto | 2001 |
Disinfection of immature teeth with a triple antibiotic paste.
Topics: Animals; Bacteria, Anaerobic; Ciprofloxacin; Colony Count, Microbial; Dental Pulp; Dogs; Drug Therap | 2005 |
Simultaneous determination of metronidazole and spiramycin I in human plasma, saliva and gingival crevicular fluid by LC-MS/MS.
Topics: Administration, Oral; Aminoglycosides; Anti-Infective Agents; Calibration; Chromatography, Liquid; C | 2005 |
Antibiotic susceptibility of the bacteria causing odontogenic infections.
Topics: Acetamides; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bact | 2006 |
Abscess of the orbit arising 48 h after root canal treatment of a maxillary first molar.
Topics: Abscess; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Drainage; Drug | 2006 |
In vitro activity of amoxicillin, clindamycin, doxycycline, metronidazole, and moxifloxacin against oral Actinomyces.
Topics: Actinomyces; Actinomycosis; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds | 2007 |
Revascularization of an immature permanent tooth with apical periodontitis and sinus tract.
Topics: Adolescent; Anti-Infective Agents, Local; Bicuspid; Ciprofloxacin; Dental Fistula; Dental Pulp; Dent | 2001 |
[Anaerobic organisms and pulp gangrene. Clinical experience in topical treatment with metronidazole].
Topics: Bacteria, Anaerobic; Dental Pulp Necrosis; Humans; Metronidazole; Periapical Periodontitis; Root Can | 1986 |
[Research on the effectiveness of metronidazole in the treatment of root infections].
Topics: Adult; Dental Pulp Necrosis; Female; Humans; Male; Metronidazole; Periapical Granuloma; Periapical P | 1985 |
[Clinical experiments with grinazole].
Topics: Adult; Aged; Dental Pulp Necrosis; Female; Humans; Male; Metronidazole; Middle Aged; Periapical Peri | 1985 |