metronidazole has been researched along with Leukocytosis in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leukocytosis: A transient increase in the number of leukocytes in a body fluid.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He had been receiving methotrexate (MTX) since boyhood for severe psoriasis." | 7.75 | [Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess]. ( Krämer, S; Maarouf, M; Müller-Lung, U, 2009) |
| " He had been receiving methotrexate (MTX) since boyhood for severe psoriasis." | 3.75 | [Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess]. ( Krämer, S; Maarouf, M; Müller-Lung, U, 2009) |
| "In most of the patients studied, ambulatory conservative management was safe and effective in the treatment of uncomplicated acute diverticulitis." | 2.74 | [Safety and efficiency of ambulatory treatment of acute diverticulitis]. ( García Marín, A; Martín Gil, J; Pérez Díaz, MD; Rey Valcárcel, C; Sanz Sánchez, M; Serralta De Colsa, D; Turégano Fuentes, F; Vaquero Rodríguez, A, 2009) |
| "None of these patients had a fever or leukocytosis at discharge." | 2.70 | Oral antibiotics in the management of perforated appendicitis in children. ( Abarbanell, A; Gollin, G; Moores, D, 2002) |
| "To review our experience in managing pyogenic liver abscesses to aid in the current management of this complex condition." | 1.46 | Pyogenic Liver Abscess: A Retrospective Study of 105 Cases in an Emergency Department from East China. ( Chen, W; Liu, L; Lu, X; Zhang, K; Zhu, C, 2017) |
| "Leukocytosis is a sign of severe CDI and is predictive for a complicated course." | 1.39 | [Case report. Leukocytosis in the course of Clostridium difficile infection]. ( Defosse, JM; Sakka, SG; Wappler, F; Weber, KS, 2013) |
| "difficile toxin, leukocytosis also tended to resolve during empiric therapy with metronidazole; some of these patients may have had C." | 1.32 | Clostridium difficile infection in patients with unexplained leukocytosis. ( Goldsmith, EA; Marino, BJ; Musher, DM; Wanahita, A, 2003) |
| "A case of amoebic liver abscess with leukaemoid reaction is reported." | 1.27 | Amoebic hepatic abscess with leukaemoid reaction. ( Agarwal, BL; Bajaj, S; Gupta, SC, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weber, KS | 1 |
| Defosse, JM | 1 |
| Wappler, F | 1 |
| Sakka, SG | 1 |
| Denes, E | 1 |
| Cypierre, A | 1 |
| Vacquier, J | 1 |
| Matt, M | 1 |
| Weinbreck, P | 1 |
| Peretz, A | 1 |
| Tkhawkho, L | 1 |
| Pastukh, N | 1 |
| Brodsky, D | 1 |
| Halevi, CN | 1 |
| Nitzan, O | 1 |
| Liu, L | 1 |
| Chen, W | 1 |
| Lu, X | 1 |
| Zhang, K | 1 |
| Zhu, C | 1 |
| Martín Gil, J | 1 |
| Serralta De Colsa, D | 1 |
| García Marín, A | 1 |
| Vaquero Rodríguez, A | 1 |
| Rey Valcárcel, C | 1 |
| Pérez Díaz, MD | 1 |
| Sanz Sánchez, M | 1 |
| Turégano Fuentes, F | 1 |
| Krämer, S | 1 |
| Maarouf, M | 1 |
| Müller-Lung, U | 1 |
| Hwang, EW | 1 |
| Cheung, L | 1 |
| Mojtahed, A | 1 |
| Cartwright, CA | 1 |
| Srivastava, A | 1 |
| Yachha, SK | 1 |
| Arora, V | 1 |
| Poddar, U | 1 |
| Lal, R | 1 |
| Baijal, SS | 1 |
| Manek, K | 1 |
| Williams, V | 1 |
| Callery, S | 1 |
| Daneman, N | 1 |
| Gollin, G | 1 |
| Abarbanell, A | 1 |
| Moores, D | 1 |
| Wanahita, A | 1 |
| Goldsmith, EA | 1 |
| Marino, BJ | 1 |
| Musher, DM | 1 |
| Belmares, J | 1 |
| Gerding, DN | 1 |
| Parada, JP | 1 |
| Miskevics, S | 1 |
| Weaver, F | 1 |
| Johnson, S | 1 |
| Bajaj, S | 1 |
| Gupta, SC | 1 |
| Agarwal, BL | 1 |
| Gorenstein, A | 1 |
| Gewurtz, G | 1 |
| Serour, F | 1 |
| Somekh, E | 1 |
| Antani, J | 1 |
| Srinivas, HV | 1 |
| Laverdant, C | 1 |
| Essioux, H | 1 |
| Cristau, P | 1 |
| Molinie, C | 1 |
| Larroque, P | 1 |
| Bernard, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fecal Calprotectin Level in Differentiating Between Inflammatory and Non-inflammatory Diarrhea in Patients With Nosocomial Diarrhea[NCT04491799] | 135 participants (Actual) | Observational | 2019-02-01 | Completed | |||
| Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090] | 134 participants (Actual) | Interventional | 2018-04-16 | Completed | |||
| Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis (Randomized, Controlled Clinical Trial)[NCT01115153] | 150 participants (Actual) | Interventional | 2007-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Leukocytosis
| Article | Year |
|---|---|
Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system.
Topics: Clostridioides difficile; Clostridium Infections; Diarrhea; Humans; Leukocytosis; Metronidazole; Ret | 2007 |
2 trials available for metronidazole and Leukocytosis
| Article | Year |
|---|---|
[Safety and efficiency of ambulatory treatment of acute diverticulitis].
Topics: Abdominal Pain; Abscess; Acute Disease; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ambulatory C | 2009 |
Oral antibiotics in the management of perforated appendicitis in children.
Topics: Administration, Oral; Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Appendectomy; Append | 2002 |
13 other studies available for metronidazole and Leukocytosis
| Article | Year |
|---|---|
[Case report. Leukocytosis in the course of Clostridium difficile infection].
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Colon; Colonoscopy; Diabetes Mellitus, Type 2 | 2013 |
Meningitis due to Fusobacterium nucleatum after a kart crash.
Topics: Anti-Infective Agents; Athletic Injuries; Bacteremia; Bacterial Translocation; Bacterial Typing Tech | 2013 |
Correlation between fecal calprotectin levels, disease severity and the hypervirulent ribotype 027 strain in patients with Clostridium difficile infection.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Clostridioides difficile; Clostridium Infect | 2016 |
Pyogenic Liver Abscess: A Retrospective Study of 105 Cases in an Emergency Department from East China.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; C-Reactive Protein; Calcitonin; Carbapenems; Cephalo | 2017 |
[Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess].
Topics: Anti-Infective Agents; Biopsy, Needle; Brain; Brain Abscess; Diagnosis, Differential; Drug Therapy, | 2009 |
Relapse of intestinal and hepatic amebiasis after treatment.
Topics: Amebicides; Antidiarrheals; Colonoscopy; Drug Therapy, Combination; Dysentery, Amebic; Humans; Iodoq | 2011 |
Identification of high-risk group and therapeutic options in children with liver abscess.
Topics: Adolescent; Anti-Infective Agents; Cefotaxime; Child; Child, Preschool; Cloxacillin; Drainage; Drug | 2012 |
Reducing the risk of severe complications among patients with Clostridium difficile infection.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antiprotozoal Agents; Comorbidity; Confusion; Entero | 2011 |
Clostridium difficile infection in patients with unexplained leukocytosis.
Topics: Anti-Infective Agents; Clostridioides difficile; Enterocolitis, Pseudomembranous; Feces; Female; Hum | 2003 |
Amoebic hepatic abscess with leukaemoid reaction.
Topics: Adult; Humans; Leukocyte Count; Leukocytosis; Liver Abscess, Amebic; Male; Metronidazole | 1984 |
Postappendectomy intra-abdominal abscess: a therapeutic approach.
Topics: Abdomen; Abscess; Adolescent; Ampicillin; Appendectomy; Child; Child, Preschool; Drainage; Female; G | 1994 |
Clinical evaluation of metronidazole in hepatic amebiasis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Cecum; Colon; Dysent | 1970 |
[Current semeiologic and therapeutic aspects of hepatic amebiasis (apropos of 60 cases)].
Topics: Antibodies; Blood Sedimentation; Emetine; Female; Fluorescent Antibody Technique; Humans; Leukocytos | 1974 |