Dracunculiasis

Infection with nematodes of the genus Dracunculus. One or more worms may be seen at a time, with the legs and feet being the most commonly infected areas. Symptoms include pruritus, nausea, vomiting, diarrhea, or asthmatic attacks.

Synonym
Dracunculosis
Guinea Worm Disease
Guinea Worm Infection
Dracunculiasis

Excerpt	Reference
"Guinea worm disease is endemic in West Africa."	( Belcher, DW; Ward, WB; Wunapa, FK, 1975)
"Dracunculiasis is a severely disabling parasitic disease."	( Agbede, K; Banzou, A; Chippaux, JP, 1992)
"Dracunculiasis is an ancient disease which international organizations are working to eradicate."	( Seim, AR, 1990)
"Dracunculiasis is now confined to only 13 countries in Africa."	( Agle, A; Diallo, N; Hopkins, DR; Ruebush, TK; Ruiz-Tiben, E; Withers, PC, 2000)
"Dracunculiasis is rarely reported in cats, yet over the last few years we have identified two cats with filarioid-like spirurid infections."	( Bowman, DD; Cama, VA; Eberhard, ML; Jenks, MH; Jones, C; Lucio-Forster, A; Pongratz, JP; Sanders, SY, 2014)
"Dracunculiasis is the first parasitic disease set for eradication."	( Galán-Puchades, MT, 2019)

Excerpt	Reference
"The annual cost of dracunculiasis has been estimated at 16,000 CFA francs per patient (US$ 60), which corresponds to 15% of a worker's income."	( Agbede, K; Banzou, A; Chippaux, JP, 1992)

Excerpt	Reference
"Traditional treatment of dracunculosis is based on manual extraction of the worm."	( Lesobre, B; Mafart, Y; Pieron, R; Puel, M; Zurbach, J, 1983)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	97 (56.07)	23.3326
1990's	44 (25.43)	12.5806
2000's	18 (10.40)	18.1394
2010's	9 (5.20)	28.8240
2020's	5 (2.89)	9.53

Drug	Relationship Strength	Studies	Trials
niacin	low	1	0
uric acid	low	1	0
albendazole	low	1	0
diatrizoic acid	low	1	0
aspirin	low	1	0
ddt	low	1	0
diethylcarbamazine	low	5	0
gentamicin	low	1	0
hexachlorophene	medium	1	1
mebendazole	medium	3	1
metronidazole	medium	16	8
praziquantel	low	1	0
promethazine	low	1	0
sulfamethoxazole	low	1	0
temefos	low	12	0
thiabendazole	medium	12	2
triclosan	low	1	0
trimethoprim	low	1	0
trichlorfon	low	1	0
edetic acid	low	1	0
niridazole	medium	5	1
cloxacillin	low	1	0
ampicillin	low	1	0
trichloroacetic acid	low	1	0
rotenone	low	1	0
diatrizoate meglumine	low	1	0
thiazoles	low	6	0
s,n,n'-tripropylthiocarbamate	low	1	0
trolamine salicylate	low	5	0
cetylpyridinium chloride anhydrous	low	1	0
tetrachloroethylene	low	1	0
diflubenzuron	low	1	0
nsc-172755	low	8	0
viccillin s (combination)	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
alpha-chymotrypsin	low	1	0
pyrantel pamoate	low	1	0
azadirachtin	low	1	0
cefotaxime	low	1	0
loa	low	8	0
chlorhexidine	low	1	0
dextrothyroxine	low	2	0
urografin 76	low	1	0
tetracycline	medium	1	1
chlortetracycline	low	1	0
minocycline	low	2	0
kaolinite	low	1	0
rome	low	2	0

Protein Targets (630)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	2	0	0	2
Luciferase	6	0	0	6
glp-1 receptor, partial	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
RAR-related orphan receptor gamma	16	0	0	16
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	4	0	0	4
TDP1 protein	13	0	0	13
GLI family zinc finger 3	15	0	0	15
AR protein	19	0	0	19
caspase 7, apoptosis-related cysteine protease	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
progesterone receptor	12	0	0	12
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	16	0	0	16
estrogen-related nuclear receptor alpha	20	0	0	20
farnesoid X nuclear receptor	14	0	0	14
pregnane X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	24	0	0	24
polyprotein	4	0	0	4
67.9K protein	5	0	0	5
peroxisome proliferator activated receptor gamma	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
caspase-3	5	0	0	5
IDH1	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Histone H2A.x	9	0	0	9
cellular tumor antigen p53 isoform a	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
chromobox protein homolog 1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	14	0	0	14
histone deacetylase 9 isoform 3	3	0	0	3
heat shock protein beta-1	9	0	0	9
mitogen-activated protein kinase 1	7	0	0	7
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	16	0	0	16
Vif	0	0	0	1
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	8	0	0	8
muscleblind-like protein 1 isoform 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	12	0	0	12
neuropeptide S receptor isoform A	4	0	0	4
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	11
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Bile salt export pump	0	13	0	13
Interferon beta	9	0	0	9
Cellular tumor antigen p53	13	0	0	13
Integrin beta-3	4	1	0	5
Integrin alpha-IIb	4	1	0	5
Methionine aminopeptidase	0	3	0	3
Glutamate receptor 2	12	0	0	12
Fatty-acid amide hydrolase 1	0	3	0	3
Inositol monophosphatase 1	6	0	0	6
Canalicular multispecific organic anion transporter 1	0	11	0	11
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	9	0	0	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	6	0	0	6
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
GLS protein	6	0	0	6
apical membrane antigen 1, AMA1	1	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
DNA polymerase beta	4	0	0	4
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
DNA polymerase kappa isoform 1	4	0	0	4
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	2
Solute carrier family 15 member 1	0	4	0	4
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	8	1	1	10
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	3
Efflux transporter	0	1	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	1	0	2
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	1	0	3
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
thioredoxin reductase	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
thyroid stimulating hormone receptor	11	0	0	11
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
EWS/FLI fusion protein	7	0	0	7
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	4	0	0	4
peroxisome proliferator-activated receptor delta	10	0	0	10
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	7	0	0	7
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	1	1	0	2
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	0	9
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
pregnane X receptor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Albumin	0	0	2	2
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	1	0	1
Beta-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	2
Chain A, Ferritin light chain	6	0	0	6
acetylcholinesterase	7	0	0	7
SMAD family member 2	9	0	0	9
USP1 protein, partial	8	0	0	8
SMAD family member 3	9	0	0	9
Microtubule-associated protein tau	7	0	0	7
estrogen receptor 2 (ER beta)	12	0	0	12
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
activating transcription factor 6	9	0	0	9
thyrotropin-releasing hormone receptor	4	0	0	4
vitamin D3 receptor isoform VDRA	6	0	0	6
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Caspase-2	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
PAX8	0	0	0	2
15-lipoxygenase, partial	3	0	0	3
phosphopantetheinyl transferase	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
PINK1	3	0	0	3
G	7	0	0	7
Parkin	3	0	0	3
heat shock protein 90	0	0	2	2
calcineurin A1, putative	0	0	1	1
thyroid stimulating hormone receptor	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
cytochrome P450 2D6 isoform 1	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	3	0	0	3
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	8	0	0	8
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
huntingtin isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
flap endonuclease 1	2	0	0	2
protein AF-9 isoform a	0	0	0	1
snurportin-1	1	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	8	0	0	8
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	8	0	0	8
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
72 kDa type IV collagenase	0	2	0	2
Matrix metalloproteinase-9	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit delta	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	8	0	0	8
Trypanothione reductase	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	8	0	0	8
Alpha-synuclein	3	1	0	4
Histamine H2 receptor	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-2	8	0	0	8
TAR DNA-binding protein 43	4	0	0	4
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
GABA theta subunit	8	0	0	8
Inositol hexakisphosphate kinase 1	7	0	0	7
Multidrug and toxin extrusion protein 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	8	0	0	8
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	7	0	0	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	7	0	7
Bile salt export pump	0	2	0	2
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Androgen receptor	0	3	0	3
endonuclease IV	2	0	0	2
nonstructural protein 1	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
M-phase phosphoprotein 8	4	0	0	4
Hsf1 protein	0	0	1	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
calpain II, partial	0	1	0	1
SUMO-1	0	1	0	1
Mcl-1	0	1	0	1
Valosin-containing protein	0	1	0	1
TSHR protein	1	0	0	1
Estrogen receptor 1	0	1	0	1
Smad3	2	0	0	2
envelope glycoprotein	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
heat shock 70kDa protein 1A	0	1	0	1
galactokinase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
neuropeptide Y receptor type 1	0	0	1	1
neuropeptide Y receptor type 2	0	0	1	1
small ubiquitin-related modifier 2 isoform b precursor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
estrogen receptor beta isoform 1	0	2	0	2
enteropeptidase precursor	1	0	0	1
fatty acid synthase	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Vpr	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
streptokinase A precursor	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	2	0	2
exodeoxyribonuclease V subunit RecB	0	2	0	2
exodeoxyribonuclease V subunit RecC	0	2	0	2
POsterior Segregation	0	0	1	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Estrogen receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	4	0	4
60 kDa chaperonin	0	1	0	1
Replicase polyprotein 1a	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	3	2	5
Muscarinic acetylcholine receptor M2	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	2	0	2
Macrophage migration inhibitory factor	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	4	0	4
Substance-K receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Thromboxane-A synthase	0	1	0	1
Mitogen-activated protein kinase 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	4
Mitogen-activated protein kinase 1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Sodium-dependent serotonin transporter	0	4	0	4
Cytochrome P450 2C19	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	3	0	3
Caspase-7	1	0	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Estrogen receptor beta	0	0	1	1
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
heat shock protein 90, putative	0	0	0	2
M1-family alanyl aminopeptidase	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
BZLF2	0	1	0	1
large T antigen	0	1	0	1
Vitamin D3 receptor	0	1	1	2
G-protein coupled bile acid receptor 1	0	0	1	1
GALC protein	1	0	0	1
PPM1D protein	3	0	0	3
Tyrosine-protein kinase ABL1	0	2	0	2
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Calmodulin-domain protein kinase 1	0	1	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Stromelysin-1	0	2	0	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Cytochrome P450 2C9	0	4	1	5
Cytochrome P450 2J2	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Polyphenol oxidase 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
arylsulfatase A	1	0	0	1
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b	0	0	1	1
Snq2p	0	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
D(1A) dopamine receptor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Transmembrane protease serine 2	0	1	1	2
Major prion protein	0	0	1	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Replicase polyprotein 1ab	0	1	1	2
Calmodulin-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	4	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Calmodulin	0	0	1	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Chloroquine resistance transporter	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Dihydrofolate reductase	0	3	0	4
Endothelin-1 receptor	1	1	0	2
Protease	0	1	1	2
polyadenylate-binding protein 1	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
BRCA1	1	0	0	1
P53	1	0	0	1
pyruvate kinase	1	0	0	1
Endothelin receptor type B	1	0	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	0	1	1
Reverse transcriptase/RNaseH	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Transthyretin	0	1	1	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
dopamine D1 receptor	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (173)

Protein Targets (630)

Dracunculiasis

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (173)

Drugs Studied (56)

Protein Targets (630)