metronidazole has been researched along with Atrophic Vaginitis in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Atrophic Vaginitis: Inflammation of the vagina due to thinning of the vaginal wall and decreased lubrication associated with reduced estrogen levels at MENOPAUSE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vaginitis is one of the most common causes of patient visits to gynecologists, primary care providers, and urgent care centers." | 2.66 | Noncandidal vaginitis: a comprehensive approach to diagnosis and management. ( Eckert, LO; Kus, LH; Neal, CM; Peipert, JF, 2020) |
| "Most patients with vulvovaginal candidiasis are diagnosed by the presence of vulvar inflammation plus vaginal discharge or with microscopic examination of vaginal secretions in 10 percent potassium hydroxide solution." | 2.47 | Vaginitis. ( Gibson, MV; Hainer, BL, 2011) |
| "Metronidazole was used only for resistant cases of trichomoniasis, with a cure rate of over 80% when both partners were treated simultaneously." | 1.24 | CLINICAL TRIALS WITH AGENTS CURRENTLY USED IN THE MANAGEMENT OF VAGINITIS. ( O'BRIEN, JR, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neal, CM | 1 |
| Kus, LH | 1 |
| Eckert, LO | 1 |
| Peipert, JF | 1 |
| Li, D | 1 |
| Bai, W | 1 |
| Hainer, BL | 1 |
| Gibson, MV | 1 |
| O'BRIEN, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Impact of Using Maternity Napkins on the Incidence of Vaginal Infections in the Post-partum Period: A Randomized Controlled Trial[NCT05806879] | 350 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | |||
| Real-world Performance and Safety of Cerviron® Medical Device in the Treatment of Various Types of Vaginitis[NCT05652959] | 111 participants (Actual) | Observational | 2021-05-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Atrophic Vaginitis
| Article | Year |
|---|---|
Noncandidal vaginitis: a comprehensive approach to diagnosis and management.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Infective Agents; Anti-Inflammatory Agents; | 2020 |
Vaginitis.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; An | 2011 |
Vaginitis.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; An | 2011 |
Vaginitis.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; An | 2011 |
Vaginitis.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; An | 2011 |
2 other studies available for metronidazole and Atrophic Vaginitis
| Article | Year |
|---|---|
Application of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis.
Topics: Administration, Intravaginal; Aged; Atrophic Vaginitis; Estradiol; Estrogens, Conjugated (USP); Fema | 2018 |
CLINICAL TRIALS WITH AGENTS CURRENTLY USED IN THE MANAGEMENT OF VAGINITIS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antifungal Agents; Atrophic Vaginitis; Bacterial | 1964 |