metronidazole has been researched along with Complications, Parasitic Pregnancy in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case-control analysis of congenital abnormalities after oral metronidazole treatment during pregnancy grouped by months of gestation." | 9.08 | A population based case-control teratologic study of oral metronidazole treatment during pregnancy. ( Czeizel, AE; Rockenbauer, M, 1998) |
| "Our purpose was to determine from published experience in humans whether metronidazole exposure during the first trimester of pregnancy is associated with an increased teratogenic risk." | 8.79 | Safety of metronidazole in pregnancy: a meta-analysis. ( Ariburnu, O; Burtin, P; Einarson, TR; Koren, G; Taddio, A, 1995) |
| "Two of my patients have been diagnosed with giardiasis, and I would like to treat them with the drug of choice for this infection, metronidazole (Flagyl)." | 7.70 | Can we use metronidazole during pregnancy and breastfeeding? Putting an end to the controversy. ( Einarson, A; Ho, E; Koren, G, 2000) |
| "Less than 20% of patients with trichomoniasis were submitted to a complete screening for other genital pathogens." | 5.56 | Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis. ( Bolumburu, C; Escario, JA; Ibáñez-Escribano, A; Muñoz-Algarra, M; Portero-Azorín, F; Zamora, V, 2020) |
| "Resistance during pregnancy has not been reported." | 5.37 | A case of high-level metronidazole-resistant trichomoniasis in pregnancy successfully treated. ( Sobel, JD; Subramanian, C, 2011) |
| "A case-control analysis of congenital abnormalities after oral metronidazole treatment during pregnancy grouped by months of gestation." | 5.08 | A population based case-control teratologic study of oral metronidazole treatment during pregnancy. ( Czeizel, AE; Rockenbauer, M, 1998) |
| "Metronidazole, given as a single dose, is likely to provide parasitological cure for trichomoniasis, but it is not known whether this treatment will have any effect on pregnancy outcomes." | 4.87 | Interventions for trichomoniasis in pregnancy. ( Azhar, M; Gülmezoglu, AM, 2011) |
| "Metronidazole, given as a single dose, is likely to provide parasitological cure for trichomoniasis, but it is not known whether this treatment will have any effect on pregnancy outcomes." | 4.81 | Interventions for trichomoniasis in pregnancy. ( Gülmezoglu, AM, 2002) |
| "Our purpose was to determine from published experience in humans whether metronidazole exposure during the first trimester of pregnancy is associated with an increased teratogenic risk." | 4.79 | Safety of metronidazole in pregnancy: a meta-analysis. ( Ariburnu, O; Burtin, P; Einarson, TR; Koren, G; Taddio, A, 1995) |
| " Metronidazole has become the drug of choice for most cases of giardiasis because of its efficacy, favorable tolerance, and availability." | 4.78 | Giardiasis. Issues in diagnosis and management. ( Hill, DR, 1993) |
| "Two of my patients have been diagnosed with giardiasis, and I would like to treat them with the drug of choice for this infection, metronidazole (Flagyl)." | 3.70 | Can we use metronidazole during pregnancy and breastfeeding? Putting an end to the controversy. ( Einarson, A; Ho, E; Koren, G, 2000) |
| "Metronidazole has proven to be a useful and inexpensive antibiotic for the treatment of T." | 2.38 | Metronidazole. ( Hager, WD; Rapp, RP, 1992) |
| "Less than 20% of patients with trichomoniasis were submitted to a complete screening for other genital pathogens." | 1.56 | Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis. ( Bolumburu, C; Escario, JA; Ibáñez-Escribano, A; Muñoz-Algarra, M; Portero-Azorín, F; Zamora, V, 2020) |
| "Women who had ≥1 pregnancy affected by Trichomonas infection were more likely to have a positive test posttreatment (adjusted odds ratio, 20." | 1.51 | Unexpected High Rates of Persistent Trichomonas vaginalis Infection in a Retrospective Cohort of Treated Pregnant Women. ( Lazenby, GB; Powell, AM; Soper, DE; Thompson, L, 2019) |
| "Resistance during pregnancy has not been reported." | 1.37 | A case of high-level metronidazole-resistant trichomoniasis in pregnancy successfully treated. ( Sobel, JD; Subramanian, C, 2011) |
| "Biliary ascariasis is one of the most common and well described entities caused by ascaris." | 1.33 | Management of biliary ascariasis in pregnancy. ( Javid, G; Khan, F; Robanni, I; Shah, OJ; Zargar, SA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (39.13) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Krispinsky, A | 1 |
| Zirwas, M | 1 |
| Bolumburu, C | 1 |
| Zamora, V | 1 |
| Muñoz-Algarra, M | 1 |
| Portero-Azorín, F | 1 |
| Escario, JA | 1 |
| Ibáñez-Escribano, A | 1 |
| Lazenby, GB | 1 |
| Thompson, L | 1 |
| Powell, AM | 1 |
| Soper, DE | 1 |
| Forbes, GL | 1 |
| Drayton, R | 1 |
| Forbes, GD | 1 |
| Byun, JM | 1 |
| Jeong, DH | 1 |
| Kim, YN | 1 |
| Lee, KB | 1 |
| Sung, MS | 1 |
| Kim, KT | 1 |
| Mann, JR | 1 |
| McDermott, S | 1 |
| Barnes, TL | 1 |
| Hardin, J | 1 |
| Bao, H | 1 |
| Zhou, L | 1 |
| Stringer, E | 1 |
| Read, JS | 1 |
| Hoffman, I | 1 |
| Valentine, M | 1 |
| Aboud, S | 1 |
| Goldenberg, RL | 1 |
| Subramanian, C | 1 |
| Sobel, JD | 1 |
| Gülmezoglu, AM | 2 |
| Azhar, M | 1 |
| Lomax, NJ | 1 |
| Estcourt, C | 1 |
| Mirakian, R | 1 |
| Shah, OJ | 1 |
| Robanni, I | 1 |
| Khan, F | 1 |
| Zargar, SA | 1 |
| Javid, G | 1 |
| Burtin, P | 1 |
| Taddio, A | 1 |
| Ariburnu, O | 1 |
| Einarson, TR | 1 |
| Koren, G | 2 |
| Hill, DR | 1 |
| Saurina, GR | 1 |
| McCormack, WM | 1 |
| Czeizel, AE | 1 |
| Rockenbauer, M | 1 |
| Coustan, DR | 1 |
| Einarson, A | 1 |
| Ho, E | 1 |
| Patial, RK | 1 |
| Kapoor, D | 1 |
| Gupta, H | 1 |
| Patial, S | 1 |
| Klebanoff, MA | 1 |
| Carey, JC | 1 |
| Hauth, JC | 1 |
| Hillier, SL | 1 |
| Nugent, RP | 1 |
| Thom, EA | 1 |
| Ernest, JM | 1 |
| Heine, RP | 1 |
| Wapner, RJ | 1 |
| Trout, W | 1 |
| Moawad, A | 1 |
| Leveno, KJ | 1 |
| Miodovnik, M | 1 |
| Sibai, BM | 1 |
| Van Dorsten, JP | 1 |
| Dombrowski, MP | 1 |
| O'Sullivan, MJ | 1 |
| Varner, M | 1 |
| Langer, O | 1 |
| McNellis, D | 1 |
| Roberts, JM | 1 |
| Hager, WD | 1 |
| Rapp, RP | 1 |
5 reviews available for metronidazole and Complications, Parasitic Pregnancy
| Article | Year |
|---|---|
Interventions for trichomoniasis in pregnancy.
Topics: Antiprotozoal Agents; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, Parasitic; | 2011 |
Interventions for trichomoniasis in pregnancy.
Topics: Antiprotozoal Agents; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, Parasitic; | 2002 |
Safety of metronidazole in pregnancy: a meta-analysis.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Metronidazole; Odds Ratio; Pregnancy; | 1995 |
Giardiasis. Issues in diagnosis and management.
Topics: Adult; Animals; Child; Child, Preschool; Female; Furazolidone; Giardia lamblia; Giardiasis; Host-Par | 1993 |
Metronidazole.
Topics: Bacterial Infections; Costs and Cost Analysis; Drug Interactions; Drug Resistance, Microbial; Entero | 1992 |
3 trials available for metronidazole and Complications, Parasitic Pregnancy
| Article | Year |
|---|---|
Treatment of trichomoniasis in pregnancy in sub-Saharan Africa does not appear to be associated with low birth weight or preterm birth.
Topics: Adult; Africa South of the Sahara; Anti-Infective Agents; Cohort Studies; Erythromycin; Female; Huma | 2010 |
A population based case-control teratologic study of oral metronidazole treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Administration, Oral; Animals; Antitricho | 1998 |
Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection.
Topics: Adult; Animals; Antitrichomonal Agents; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, | 2001 |
15 other studies available for metronidazole and Complications, Parasitic Pregnancy
| Article | Year |
|---|---|
Nodular Demodicosis in a Pregnant Woman Treated with Oral Ivermectin and Metronidazole.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Antiparasitic Agents; Drug Therapy, Combination; | 2019 |
Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis.
Topics: Adult; Coinfection; Drug Resistance; Female; Gonorrhea; Humans; Metronidazole; Middle Aged; Mycoplas | 2020 |
Unexpected High Rates of Persistent Trichomonas vaginalis Infection in a Retrospective Cohort of Treated Pregnant Women.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Female; Humans; Logistic Models; Metr | 2019 |
A case of metronidazole-resistant Trichomonas vaginalis in pregnancy.
Topics: Antitrichomonal Agents; Drug Resistance; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complic | 2016 |
Experience of successful treatment of patients with metronidazole-resistant Trichomonas vaginalis with zinc sulfate: A case series.
Topics: Adult; Animals; Antiprotozoal Agents; Astringents; Drug Resistance; Female; Follow-Up Studies; Human | 2015 |
Trichomoniasis in pregnancy and mental retardation in children.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Incidence; Infant; Infant, Newborn; Intellectua | 2009 |
A case of high-level metronidazole-resistant trichomoniasis in pregnancy successfully treated.
Topics: Adult; Anti-Infective Agents; Antitrichomonal Agents; Drug Resistance, Microbial; Female; Humans; Me | 2011 |
Symptomatic trichomoniasis, metronidazole allergic and pregnant--a management dilemma.
Topics: Adult; Animals; Anti-Infective Agents, Local; Antitrichomonal Agents; Clotrimazole; Drug Hypersensit | 2004 |
Management of biliary ascariasis in pregnancy.
Topics: Adult; Ampicillin; Anti-Infective Agents; Ascariasis; Biliary Tract Diseases; Cholangiopancreatograp | 2005 |
Trichomoniasis in pregnancy.
Topics: Abnormalities, Drug-Induced; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, Para | 1997 |
Use of metronidazole during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anti-Infective Agents; Contraindications; Female; Hu | 1999 |
National guideline for the management of Trichomonas vaginalis. Clinical Effectiveness Group (Association for Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases).
Topics: Adult; Animals; Antitrichomonal Agents; Breast Feeding; Child, Preschool; Female; Humans; Infectious | 1999 |
Can we use metronidazole during pregnancy and breastfeeding? Putting an end to the controversy.
Topics: Adult; Anti-Infective Agents; Breast Feeding; Female; Giardiasis; Humans; Metronidazole; Practice Gu | 2000 |
Drugs for sexually transmitted infections.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antitrichomonal Agents; Azithromycin; Chlamydia | 1999 |
Amoebic liver abscess in pregnancy.
Topics: Adult; Combined Modality Therapy; Drainage; Female; Humans; India; Liver Abscess, Amebic; Metronidaz | 1998 |