metronidazole has been researched along with Dental Focal Infection in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a healthcare profession, dentists have a role in ensuring the safety of prescribed medicines by reporting adverse drug reactions using the Yellow Card Scheme." | 6.53 | Metronidazole and tinnitus: A potential side effect? ( Barker, D; O'Donnell, KL, 2016) |
| "As a healthcare profession, dentists have a role in ensuring the safety of prescribed medicines by reporting adverse drug reactions using the Yellow Card Scheme." | 2.53 | Metronidazole and tinnitus: A potential side effect? ( Barker, D; O'Donnell, KL, 2016) |
| "We report a patient with multiple brain abscesses due to infection with A." | 2.47 | Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature. ( Engström, LJ; Manson, WL; Mooi-Kokenberg, EA; Rahamat-Langendoen, JC; van Vonderen, MG; van Winkelhoff, AJ, 2011) |
| "Brain abscess is a rare but life-threatening complication of pregnancy." | 1.37 | Pregnancy complicated by recurrent brain abscess after extraction of an infected tooth. ( Awonuga, AO; Hobson, DTG; Imudia, AN; Soto, E, 2011) |
| "We report a case of cervical necrotizing fasciitis arising from a dental infection and review the cause, pathophysiology, diagnosis and treatment of this potentially lethal entity." | 1.29 | Management of necrotizing fasciitis in the neck. ( Bossuyt, M; De Backer, T; Schoenaers, J, 1996) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bali, R | 1 |
| Sharma, P | 1 |
| Gaba, S | 1 |
| O'Donnell, KL | 1 |
| Barker, D | 1 |
| Al-Qamachi, LH | 1 |
| Aga, H | 1 |
| McMahon, J | 1 |
| Leanord, A | 1 |
| Hammersley, N | 1 |
| Ertaş, U | 1 |
| Yalçin, E | 1 |
| Rao, DD | 1 |
| Desai, A | 1 |
| Kulkarni, RD | 1 |
| Gopalkrishnan, K | 1 |
| Rao, CB | 1 |
| Rahamat-Langendoen, JC | 1 |
| van Vonderen, MG | 1 |
| Engström, LJ | 1 |
| Manson, WL | 1 |
| van Winkelhoff, AJ | 1 |
| Mooi-Kokenberg, EA | 1 |
| Hobson, DTG | 1 |
| Imudia, AN | 1 |
| Soto, E | 1 |
| Awonuga, AO | 1 |
| Brescó-Salinas, M | 1 |
| Costa-Riu, N | 1 |
| Berini-Aytés, L | 1 |
| Gay-Escoda, C | 1 |
| Palmer, NO | 1 |
| Wagner, KW | 1 |
| Schön, R | 1 |
| Schumacher, M | 1 |
| Schmelzeisen, R | 1 |
| Schulze, D | 1 |
| Zeitoun, IM | 1 |
| Dhanarajani, PJ | 1 |
| Bridgeman, A | 1 |
| Wiesenfeld, D | 1 |
| Hellyar, A | 1 |
| Sheldon, W | 1 |
| De Backer, T | 1 |
| Bossuyt, M | 1 |
| Schoenaers, J | 1 |
| Tsarev, VN | 1 |
| Ushakov, RV | 1 |
| Lung, KE | 1 |
| Sigusch, B | 1 |
| Pfister, W | 1 |
| Klinger, G | 1 |
| Glockmann, E | 1 |
| Weeda, LW | 1 |
| Ingham, HR | 1 |
| Hood, FJ | 1 |
| Bradnum, P | 1 |
| Tharagonnet, D | 1 |
| Selkon, JB | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| Mitre, RJ | 1 |
| Rotheran, EB | 1 |
3 reviews available for metronidazole and Dental Focal Infection
| Article | Year |
|---|---|
Metronidazole and tinnitus: A potential side effect?
Topics: Anti-Infective Agents; Female; Focal Infection, Dental; Gingivitis; Humans; Metronidazole; Middle Ag | 2016 |
Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Anti | 2011 |
Cervical cellulitis and mediastinitis caused by odontogenic infections: report of two cases and review of literature.
Topics: Adult; Amikacin; Fatal Outcome; Focal Infection, Dental; Humans; Ludwig's Angina; Male; Mediastinal | 1995 |
3 trials available for metronidazole and Dental Focal Infection
| Article | Year |
|---|---|
Use of metronidazole as part of an empirical antibiotic regimen after incision and drainage of infections of the odontogenic spaces.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Bacteriological Techniq | 2015 |
[Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis].
Topics: Administration, Oral; Adolescent; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Chemot | 2000 |
Metronidazole compared with penicillin in the treatment of acute dental infections.
Topics: Adult; Bacterial Infections; Clinical Trials as Topic; Drug Evaluation; Female; Focal Infection, Den | 1977 |
14 other studies available for metronidazole and Dental Focal Infection
| Article | Year |
|---|---|
Microbiology of odontogenic infections in deep neck spaces: a retrospective study.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria, Anaerobic; Cefuroxime; Combined Modality The | 2010 |
Chronic temporal abscess resulting from a periapical abscess of the upper right first molar.
Topics: Abscess; Anti-Bacterial Agents; Ceftriaxone; Drainage; Female; Focal Infection, Dental; Humans; Inje | 2009 |
Comparison of maxillofacial space infection in diabetic and nondiabetic patients.
Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Case-Control Studi | 2010 |
Pregnancy complicated by recurrent brain abscess after extraction of an infected tooth.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Brain Abscess; Cefotaxime; Cesarean Section; Dexameth | 2011 |
Antibiotic susceptibility of the bacteria causing odontogenic infections.
Topics: Acetamides; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bact | 2006 |
Pharmaceutical prescribing for children. Part 3. Antibiotic prescribing for children with odontogenic infections.
Topics: Amoxicillin; Anti-Bacterial Agents; Azithromycin; Erythromycin; Focal Infection, Dental; Humans; Met | 2006 |
Case report: brain and liver abscesses caused by oral infection with Streptococcus intermedius.
Topics: Adult; Anti-Bacterial Agents; Brain Abscess; Drainage; Focal Infection, Dental; Humans; Liver Absces | 2006 |
Major maxillofacial infections. An evaluation of 107 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Clinical Pr | 1995 |
Management of necrotizing fasciitis in the neck.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cilastatin; Combined Modality Therapy; Debridem | 1996 |
[The immunomodulating therapy of odontogenic phlegmons with complexes of antibacterial preparations and water-soluble polymers for medical use].
Topics: Adjuvants, Immunologic; Anti-Infective Agents, Local; Cellulitis; Colloids; Dextrans; Drug Evaluatio | 1996 |
Clindamycin or penicillin V?
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Clindamycin; Focal Infection, Dental; Humans; Metronid | 1999 |
Erythromycin and amoxicillin?
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Cephalosporins; Clind | 2001 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
Anaerobic septicemia from thrombophlebitis of the internal jugular vein. Successful treatment with metronidazole.
Topics: Adult; Anaerobiosis; Bacteria; Drug Evaluation; Drug Resistance, Microbial; Focal Infection, Dental; | 1974 |