| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
adenine
[no description available] | 2.69 | 3 | 0 | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
cytosine
[no description available] | 2.42 | 2 | 0 | aminopyrimidine;
pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
purine
1H-purine : The 1H-tautomer of purine.. 3H-purine : The 3H-tautomer of purine.. 9H-purine : The 9H-tautomer of purine.. 7H-purine : The 7H-tautomer of purine. | 1.92 | 1 | 0 | purine | |
thymine
[no description available] | 1.96 | 1 | 0 | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder | 1.96 | 1 | 0 | pyrimidine nucleobase;
pyrimidone | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite |
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | 2.07 | 1 | 0 | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic |
pargyline
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties. | 2.1 | 1 | 0 | aromatic amine | |
thymidine
[no description available] | 1.96 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite |
idoxuridine
[no description available] | 1.96 | 1 | 0 | organoiodine compound;
pyrimidine 2'-deoxyribonucleoside | antiviral drug;
DNA synthesis inhibitor |
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | 2.15 | 1 | 0 | adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | fundamental metabolite;
human metabolite |
uridine
[no description available] | 2.11 | 1 | 0 | uridines | drug metabolite;
fundamental metabolite;
human metabolite |
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. | 1.96 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent |
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | 2.5 | 2 | 0 | adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical |
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group. | 1.96 | 1 | 0 | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
cytidine
[no description available] | 1.98 | 1 | 0 | cytidines | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus. | 2.41 | 2 | 0 | antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside | antimetabolite;
antineoplastic agent;
bacterial metabolite |
cordycepin
[no description available] | 2.07 | 1 | 0 | 3'-deoxyribonucleoside;
adenosines | antimetabolite;
nucleoside antibiotic |
2-chloroadenosine
5-chloroformycin A: structure given in first source | 2.15 | 1 | 0 | purine nucleoside | |
2-fluoroadenosine
[no description available] | 2.41 | 2 | 0 | adenosines;
organofluorine compound | |
diazomethane
Diazomethane: A diazonium compound with the formula CH2N2.. diazomethane : The simplest diazo compound, in which a diazo group is attached to a methylene group. | 7.03 | 1 | 0 | diazo compound | alkylating agent;
antineoplastic agent;
carcinogenic agent;
poison |
methylthioinosine
Methylthioinosine: 6-(Methylthio)-9-beta-D-ribofuranosylpurine. An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. | 2.69 | 3 | 0 | purine ribonucleoside;
thiopurine | |
2-aminopurine
2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position. | 2.15 | 1 | 0 | 2-aminopurines;
nucleobase analogue | antimetabolite |
2-fluoroadenine
2-fluoroadenine : An organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. | 2.15 | 1 | 0 | organofluorine compound;
purines | antineoplastic agent |
2'-deoxyadenosine
2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source | 2.07 | 1 | 0 | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
deoxycytidine monophosphate
Deoxycytidine Monophosphate: Deoxycytidine (dihydrogen phosphate). A deoxycytosine nucleotide containing one phosphate group esterified to the deoxyribose moiety in the 2'-,3'- or 5- positions.. 2'-deoxycytosine 5'-monophosphate : A pyrimidine 2'-deoxyribonucleoside 5'-monophosphate having cytosine as the nucleobase. | 2.06 | 1 | 0 | 2'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate | Escherichia coli metabolite;
mouse metabolite |
6-hydroxyadenosine
[no description available] | 1.96 | 1 | 0 | | |
9-benzyladenine
[no description available] | 2.15 | 1 | 0 | | |
hyaluronoglucosaminidase
kinetin riboside: preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells; structure in first source | 2 | 1 | 0 | purine nucleoside | |
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. | 2.89 | 4 | 0 | beta-D-arabinoside;
purine nucleoside | antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic |
3-deazaadenosine
3-deazaadenosine: RN given refers to parent cpd. | 2.37 | 2 | 0 | | |
isopentenyladenosine
Isopentenyladenosine: N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant growth regulators.. N(6)-(Delta(2)-isopentenyl)adenosine : A nucleoside analogue in which adenosine has been modified by substitution at the 6-amino nitrogen by a Delta(2)-isopentenyl group. | 2.05 | 1 | 0 | N-ribosyl-N(6)-isopentenyladenine;
nucleoside analogue | antineoplastic agent;
plant growth regulator;
plant metabolite |
2,6-diaminopurine
9H-purine-2,6-diamine : A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups. | 2.15 | 1 | 0 | 2,6-diaminopurines;
primary amino compound | antineoplastic agent |
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3. | 2.1 | 1 | 0 | pseudohalide anion | mitochondrial respiratory-chain inhibitor |
triciribine phosphate
[no description available] | 2.06 | 1 | 0 | | |
adefovir
adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. | 2.41 | 2 | 0 | 6-aminopurines;
ether;
phosphonic acids | antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent |
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. | 1.97 | 1 | 0 | phosphonic acids;
pyrimidone | anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent |
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | 4.63 | 27 | 0 | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent |
benzylaminopurine
benzylaminopurine: a plant growth regulator. N-benzyladenine : A member of the class of 6-aminopurines that is adenine in which one of the hydrogens of the amino group is replaced by a benzyl group. | 2.05 | 1 | 0 | 6-aminopurines | cytokinin;
plant metabolite |
xanthosine
[no description available] | 2.45 | 2 | 0 | purines D-ribonucleoside;
xanthosines | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
[no description available] | 1.97 | 1 | 0 | | |
isoguanosine
[no description available] | 2.46 | 2 | 0 | purine nucleoside | |
phosphoramidic acid
phosphoramidic acid: urease inhibitor; RN given refers to parent cpd; structure; do not confuse with phosphoramidites, which are organophosphorus compounds | 1.98 | 1 | 0 | phosphoric acid derivative | |
metrifudil
[no description available] | 2 | 1 | 0 | | |
isocytosine
2-amino-4-hydroxypyrimidine : An aminopyrimidine in which the pyrimidine ring bears amino and hydroxy substituents at positions 2 and 4, respectively. | 2.11 | 1 | 0 | aminopyrimidine;
pyrimidine nucleobase;
pyrimidone | |
pyrazolo(3,4-d)pyrimidine
[no description available] | 2.03 | 1 | 0 | | |
nebularine
nebularine: structure. nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage. | 2.05 | 1 | 0 | purine ribonucleoside;
purines D-ribonucleoside | fungal metabolite |
9-methyladenine
9-methyladenine : Adenine substituted with a methyl group at position N-9. | 2.15 | 1 | 0 | methyladenine | metabolite |
8-azaadenine
8-azaadenine: xanthine oxidase inhibitor. 8-azaadenine : A triazolopyrimidine that is [1,2,3]triazolo[4,5-d]pyrimidine bearing an amino substituent at position 7. | 2.15 | 1 | 0 | aromatic amine;
nucleobase analogue;
triazolopyrimidines | EC 1.17.3.2 (xanthine oxidase) inhibitor;
Mycoplasma genitalium metabolite |
D-alanine
[no description available] | 2.05 | 1 | 0 | alanine zwitterion;
alanine;
D-alpha-amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
Escherichia coli metabolite;
human metabolite |
7-methyladenine
7-methyladenine: potential marker for monitoring exposure to methylatingcarcinogens. 7-methyladenine : Adenine substituted with a methyl group at position N-7. | 2.15 | 1 | 0 | methyladenine | metabolite |
adenosine 2',3'-ribo-epoxide
adenosine 2',3'-ribo-epoxide: structure | 2.07 | 1 | 0 | | |
n(6)-benzyladenosine
N(6)-benzyladenosine: RN given refers to parent cpd | 2 | 1 | 0 | | |
5-methylcytidine
[no description available] | 1.98 | 1 | 0 | methylcytidine | |
6-chloropurine riboside
[no description available] | 2.4 | 2 | 0 | | |
2-chloroadenine
6-amino-2-chloropurine: RN & structure given in first source | 2.15 | 1 | 0 | | |
6'-o-methylguanosine
[no description available] | 2.74 | 3 | 0 | | |
8-azaadenosine
[no description available] | 1.96 | 1 | 0 | N-glycosyl compound | |
8-aminoadenosine
[no description available] | 2.39 | 2 | 0 | | |
n-allyladenosine
[no description available] | 2 | 1 | 0 | purine nucleoside | |
2'-fluoro-2'-deoxyadenosine
[no description available] | 2.07 | 1 | 0 | | |
n(6)-phenyladenosine
[no description available] | 2.15 | 1 | 0 | purine nucleoside | |
n-methyladenosine
N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase. | 2.73 | 3 | 0 | methyladenosine | |
9-(2,3-dihydroxypropyl)adenine
[no description available] | 2.15 | 1 | 0 | | |
3'-fluoro-3'-deoxyadenosine
3'-fluoro-3'-deoxyadenosine: structure given in first source | 2.07 | 1 | 0 | | |
5'-deoxy-5'-s-isobutylthioadenosine
5'-deoxy-5'-S-isobutylthioadenosine: considered an analog of S-adenosylhomocysteine; structure | 2.07 | 1 | 0 | | |
6-methoxypurine arabinoside
[no description available] | 2.37 | 2 | 0 | | |
o(6)-methyldeoxyguanylic acid
O(6)-methyldeoxyguanylic acid: incorporated into DNA by DNA polymerase I & II | 2.06 | 1 | 0 | | |
etheno-amp
[no description available] | 2.06 | 1 | 0 | | |
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid. | 1.97 | 1 | 0 | divalent inorganic anion;
phosphite ion | |
n(6),n(6)-dimethyladenosine
N(6),N(6)-dimethyladenosine : A methyladenosine compound with two methyl groups attached to N(6) of the adenine nucleobase. | 2.05 | 1 | 0 | hydrocarbyladenosine | |
adenosine 5'-phosphoramidate
adenosine 5'-phosphoramidate : The phosphoramadite analogue of AMP. | 2.06 | 1 | 0 | organic phosphoramidate | Mycoplasma genitalium metabolite |
abacavir
abacavir: a carbocyclic nucleoside with potent selective anti-HIV activity. abacavir : A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection. | 2.06 | 1 | 0 | 2,6-diaminopurines | antiviral drug;
drug allergen;
HIV-1 reverse transcriptase inhibitor |
formycin
[no description available] | 1.96 | 1 | 0 | formycin | antineoplastic agent |
2'-amino-2'-deoxyadenosine
[no description available] | 1.97 | 1 | 0 | | |
2'-deoxy-2-fluoroadenosine
2'-deoxy-2-fluoroadenosine: structure in first source | 2 | 1 | 0 | adenosines;
organofluorine compound | |
carbodine
carbodine: RN given refers to (R-(1alpha,2beta,3beta,4alpha))-isomer | 1.96 | 1 | 0 | | |
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. | 2.06 | 1 | 0 | nucleoside analogue;
phosphonic acids | antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor |
fludarabine
[no description available] | 1.96 | 1 | 0 | purine nucleoside | |
n(6)-cyclopentyladenosine
[no description available] | 2 | 1 | 0 | | |
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis. | 2.05 | 1 | 0 | aryl thiol;
purines;
thiocarbonyl compound | anticoronaviral agent;
antimetabolite;
antineoplastic agent |
thioinosine
Thioinosine: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503) | 2.05 | 1 | 0 | | |
2-mercaptobenzimidazole
2-mercaptobenzimidazole: purine synthesis antimetabolite; RN given refers to parent cpd | 2.05 | 1 | 0 | | |
thiouracil
Thiouracil: Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.. thiouracil : A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group. | 2.05 | 1 | 0 | nucleobase analogue;
thiocarbonyl compound | antithyroid drug;
metabolite |
pyrimidine-2-thiol
pyrimidine-2-thiol: RN given refers to parent cpd. pyrimidine-2-thiol : Pyrimidine substituted at C-2 by a sulfanyl group. | 2.05 | 1 | 0 | aryl thiol;
pyrimidines | allergen;
corrosion inhibitor |
thioguanine anhydrous
Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia. | 2.05 | 1 | 0 | 2-aminopurines | anticoronaviral agent;
antimetabolite;
antineoplastic agent |
2-thiopyridine
2-thiopyridine: RN given refers to parent cpd. pyridine-2-thiol : Pyridine substituted at C-2 by a sulfanyl group. | 2.05 | 1 | 0 | aryl thiol;
pyridines | allergen;
fluorescence quencher |
4-thiopyridine
4-thiopyridine: RN given refers to 4-thiopyridine cpd | 2.05 | 1 | 0 | | |
6-thioguanosine
6-thioguanosine: RN given refers to cpd without isomeric designation | 2.45 | 2 | 0 | purine nucleoside | |
6-thioguanylic acid
[no description available] | 2.06 | 1 | 0 | organic molecule | |
5'-chloro-5'-deoxyadenosine
[no description available] | 2.07 | 1 | 0 | adenosines | |
2-amino-6-chloropurine
6-chloroguanine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure in first source. 6-chloroguanine : An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. | 2.49 | 2 | 0 | 2-aminopurines;
organochlorine compound | |
6-benzylthioinosine
6-benzylthioinosine: a subversive substrate of T gondii adenosine kinase; structure in first source | 2.05 | 1 | 0 | | |
2'-amino-2'-deoxyuridine
2'-amino-2'-deoxyuridine: structure in first source | 2.07 | 1 | 0 | | |
cv 1808
2-phenylaminoadenosine: has coronary & cardiohemodynamic effects | 1.97 | 1 | 0 | purine nucleoside | |
5'-amino-5'-deoxyadenosine
[no description available] | 2.07 | 1 | 0 | | |
n(6)-cyclohexyladenosine
N(6)-cyclohexyladenosine: structure given in first source; receptors, purinergic P1 agonist | 2 | 1 | 0 | | |
n(6)-(2,2-diphenylethyl)adenosine
N(6)-(2,2-diphenylethyl)adenosine: adenosine receptor agonist; structure given in first source | 2 | 1 | 0 | | |
isoguanosine
[no description available] | 7.47 | 2 | 0 | | |
oligonucleotides
[no description available] | 7.4 | 2 | 0 | | |
sofosbuvir
Sofosbuvir: A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.. sofosbuvir : A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection. | 2.13 | 1 | 0 | isopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester | antiviral drug;
hepatitis C protease inhibitor;
prodrug |
bms-986094
BMS-986094: a prodrug of 2'-C-methylguanosine and antiviral agent | 2.13 | 1 | 0 | | |
guanosine monophosphate
Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase. | 2.13 | 1 | 0 | guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite |
guanine
[no description available] | 2.42 | 2 | 0 | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose. | 3.16 | 5 | 0 | guanosines;
purines D-ribonucleoside | fundamental metabolite |
hypoxanthine
[no description available] | 2.15 | 1 | 0 | nucleobase analogue;
oxopurine;
purine nucleobase | fundamental metabolite |
inosine
[no description available] | 3.01 | 4 | 0 | inosines;
purines D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
ganciclovir
[no description available] | 2.05 | 1 | 0 | 2-aminopurines;
oxopurine | antiinfective agent;
antiviral drug |
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. | 2.05 | 1 | 0 | nucleobase analogue;
organic heterobicyclic compound | antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger |
azaguanine
Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.. 8-azaguanine : A triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively. | 1.96 | 1 | 0 | nucleobase analogue;
triazolopyrimidines | antimetabolite;
antineoplastic agent;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor |
2'-o-methylguanosine
2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group. | 2.03 | 1 | 0 | methylguanosine | metabolite |
8-hydroxyguanosine
8-hydroxyguanosine: immunostimulant for B lymphocytes; structure given in first source | 2.05 | 1 | 0 | purine nucleoside | |
7-deazainosine
[no description available] | 2.05 | 1 | 0 | | |
carbocyclic inosine
carbocyclic inosine: anti-Leishmanial agent; structure given in first source | 1.96 | 1 | 0 | | |
9-(3-hydroxy-2-phosphonomethoxypropyl)guanine
9-(3-hydroxy-2-phosphonomethoxypropyl)guanine: structure given in first source; RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 3/89 | 1.97 | 1 | 0 | | |
3'-o-methylguanosine
3'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-3' substituted with a methyl group. | 2.03 | 1 | 0 | methylguanosine | metabolite |
7-methylinosine
7-methylinosine : A positively charged methylinosine in which a single methyl substituent is located at position 7 on the hypoxanthine ring. | 2.05 | 1 | 0 | inosines;
organic cation | metabolite |