metronidazole has been researched along with Chondrosarcoma in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Chondrosarcoma: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with topical clobetasol and oral metronidazole led to partial resolution of the lesions with postinflammatory hyperpigmentation." | 7.96 | Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report. ( Aung, PP; Curry, JL; Farah, M; Nagarajan, P; Nelson, KC; Prieto, VG; Tetzlaff, MT; Torres-Cabala, CA, 2020) |
| " Treatment with topical clobetasol and oral metronidazole led to partial resolution of the lesions with postinflammatory hyperpigmentation." | 3.96 | Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report. ( Aung, PP; Curry, JL; Farah, M; Nagarajan, P; Nelson, KC; Prieto, VG; Tetzlaff, MT; Torres-Cabala, CA, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farah, M | 1 |
| Nelson, KC | 1 |
| Tetzlaff, MT | 1 |
| Nagarajan, P | 1 |
| Torres-Cabala, CA | 1 |
| Prieto, VG | 1 |
| Curry, JL | 1 |
| Aung, PP | 1 |
1 other study available for metronidazole and Chondrosarcoma
| Article | Year |
|---|---|
Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report.
Topics: Administration, Oral; Administration, Topical; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents | 2020 |