metronidazole has been researched along with Central Nervous System Diseases in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess." | 3.69 | Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report. ( Lawford, R; Sorrell, TC, 1994) |
| "In many neurosurgery-associated infections, intrathecal or intraventricular antibiotics may be required to supplement parenteral treatment and/or surgical intervention." | 2.36 | Antimicrobial agents and the central nervous system. ( Everett, ED; Strausbaugh, LJ, 1980) |
| " Metronidazole dosage ranged from 67." | 1.28 | Central nervous system toxicosis associated with metronidazole treatment of dogs: five cases (1984-1987). ( Beadleston, D; Dow, SW; LeCouteur, RA; Poss, ML, 1989) |
| "Of 33 patients with amoebic liver abscess (ALA) seen over a 5-year period, 24 had intrathoracic complications." | 1.27 | Intrathoracic complications of amoebic liver abscess. ( Aderounmu, A; Adeyemo, AO, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olson, EJ | 1 |
| Morales, SC | 1 |
| McVey, AS | 1 |
| Hayden, DW | 1 |
| Everett, ED | 1 |
| Strausbaugh, LJ | 1 |
| Moldenhauer, H | 1 |
| Rose, H | 1 |
| Saul, G | 1 |
| Wolf, G | 1 |
| Kehrberg, G | 1 |
| Snavely, SR | 1 |
| Hodges, GR | 1 |
| Adeyemo, AO | 1 |
| Aderounmu, A | 1 |
| Jokipii, AM | 2 |
| Jokipii, L | 2 |
| Lawford, R | 1 |
| Sorrell, TC | 1 |
| Suzuki, M | 1 |
| Myllylä, VV | 1 |
| Hokkanen, E | 1 |
| Nelson, JD | 1 |
| Dow, SW | 1 |
| LeCouteur, RA | 1 |
| Poss, ML | 1 |
| Beadleston, D | 1 |
4 reviews available for metronidazole and Central Nervous System Diseases
| Article | Year |
|---|---|
Antimicrobial agents and the central nervous system.
Topics: Abscess; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Diseases; Cephalospori | 1980 |
[Modification of the radiation effects for overcoming radiation-resistant hypoxic tumor tissue].
Topics: Amifostine; Animals; Central Nervous System Diseases; Dogs; Humans; Hyperthermia, Induced; In Vitro | 1983 |
The neurotoxicity of antibacterial agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Disea | 1984 |
[Neurological toxicity of antifungal and antiprotozoal drugs].
Topics: Amphotericin B; Antifungal Agents; Antimalarials; Antiprotozoal Agents; Antitrichomonal Agents; Cent | 1999 |
7 other studies available for metronidazole and Central Nervous System Diseases
| Article | Year |
|---|---|
Putative metronidazole neurotoxicosis in a cat.
Topics: Animals; Anti-Infective Agents; Brain Stem; Cat Diseases; Cats; Central Nervous System Diseases; Met | 2005 |
Intrathoracic complications of amoebic liver abscess.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Drainage; Empyema; Female; Fistula; Human | 1984 |
Metronidazole, tinidazole, ornidazole and anaerobic infections of the middle ear, maxillary sinus and central nervous system.
Topics: Bacterial Infections; Central Nervous System Diseases; Humans; Maxillary Sinus; Metronidazole; Nitro | 1981 |
Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.
Topics: Adult; Amebiasis; Ataxia; Central Nervous System Diseases; Humans; Liver Abscess, Amebic; Male; Metr | 1994 |
Penetration of the blood brain barrier by metronidazole and tinidazole.
Topics: Animals; Bacterial Infections; Bacteroides Infections; Blood-Brain Barrier; Central Nervous System D | 1977 |
Odd creatures in the blood and cerebrospinal fluid.
Topics: Bacterial Infections; Bacteroides Infections; Central Nervous System Diseases; Chloramphenicol; Clin | 1976 |
Central nervous system toxicosis associated with metronidazole treatment of dogs: five cases (1984-1987).
Topics: Animals; Central Nervous System Diseases; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Fema | 1989 |