metronidazole has been researched along with Pulmonary Consumption in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was given for a total of 3 weeks, and 2 weeks after discontinuation of metronidazole, she presented with recurrent chest pain and was diagnosed with active pulmonary tuberculosis." | 1.39 | [A case of pulmonary tuberculosis in which diagnosis was delayed because of prior treatment with fluoroquinolone and metronidazole]. ( Ema, R; Morioka, S; Nakamura, H; Sakurai, A; Tomita, K, 2013) |
| "Metronidazole (MTZ), which has activity only against anaerobic, nonreplicating bacteria, was as effective as either of these treatments in preventing reactivation of latent infection." | 1.38 | Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. ( Barry, CE; Dartois, V; Flynn, JL; Goodwin, MB; Janssen, C; Johnston, PJ; Klein, E; Lin, PL; Via, L, 2012) |
| "Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation." | 1.35 | Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. ( Basaraba, RJ; Brooks, EJ; Caraway, ML; Driver, ER; Hoff, DR; Lenaerts, AJ; Orme, IM; Peloquin, CA; Ryan, GJ, 2008) |
| "The mainstay of the treatment of actinomycosis remains to be a combination of abscess drainage as well as prolonged antibiotics such as penicillin." | 1.35 | Thoracic actinomycosis in an adolescent mimicking chest wall tumor or pulmonary tuberculosis. ( Chao, NS; Kwok, WK; Leung, MW; Wong, QH; Yeung, VH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tangallapally, RP | 1 |
| Yendapally, R | 1 |
| Lee, RE | 2 |
| Hevener, K | 1 |
| Jones, VC | 1 |
| Lenaerts, AJ | 3 |
| McNeil, MR | 1 |
| Wang, Y | 1 |
| Franzblau, S | 1 |
| Bitting, C | 1 |
| Woolhiser, L | 1 |
| Gruppo, V | 1 |
| Marietta, KS | 1 |
| Johnson, CM | 1 |
| Orme, IM | 2 |
| Hoff, DR | 1 |
| Caraway, ML | 1 |
| Brooks, EJ | 1 |
| Driver, ER | 1 |
| Ryan, GJ | 1 |
| Peloquin, CA | 1 |
| Basaraba, RJ | 1 |
| Cerezo Lajas, A | 1 |
| Caminero Luna, JA | 1 |
| Rodríguez Guzmán, MDC | 1 |
| de Miguel Díez, J | 1 |
| Morioka, S | 1 |
| Ema, R | 1 |
| Sakurai, A | 1 |
| Tomita, K | 1 |
| Nakamura, H | 1 |
| Verma, S | 1 |
| Verma, G | 1 |
| Singh, DV | 1 |
| Mokta, J | 1 |
| Negi, RS | 1 |
| Jhobta, A | 1 |
| Kanga, A | 1 |
| Lin, PL | 2 |
| Dartois, V | 1 |
| Johnston, PJ | 1 |
| Janssen, C | 1 |
| Via, L | 1 |
| Goodwin, MB | 1 |
| Klein, E | 2 |
| Barry, CE | 2 |
| Flynn, JL | 2 |
| Zhang, Y | 1 |
| Gibbons, FK | 1 |
| Branda, JA | 1 |
| Shepard, JA | 1 |
| Via, LE | 1 |
| Ray, SM | 1 |
| Carrillo, J | 1 |
| Allen, SS | 1 |
| Eum, SY | 1 |
| Taylor, K | 1 |
| Manjunatha, U | 1 |
| Gonzales, J | 1 |
| Lee, EG | 1 |
| Park, SK | 1 |
| Raleigh, JA | 1 |
| Cho, SN | 1 |
| McMurray, DN | 1 |
| Yeung, VH | 1 |
| Wong, QH | 1 |
| Chao, NS | 1 |
| Leung, MW | 1 |
| Kwok, WK | 1 |
| Flenley, DC | 1 |
| Okomé-Nkoumou, M | 1 |
| Kombila, M | 1 |
| Weber, I | 1 |
| Fabre, J | 1 |
| Desai, CR | 1 |
| Heera, S | 1 |
| Patel, A | 1 |
| Babrekar, AB | 1 |
| Mahashur, AA | 1 |
| Kamat, SR | 1 |
1 review available for metronidazole and Pulmonary Consumption
| Article | Year |
|---|---|
New drugs in respiratory disorders: II.
Topics: Adult; Aged; Amantadine; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cephalosporins; | 1983 |
1 trial available for metronidazole and Pulmonary Consumption
| Article | Year |
|---|---|
Role of metronidazole in improving response and specific drug sensitivity in advanced pulmonary tuberculosis.
Topics: Adolescent; Adult; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Male; Metronida | 1989 |
13 other studies available for metronidazole and Pulmonary Consumption
| Article | Year |
|---|---|
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents.
Topics: Amides; Animals; Antitubercular Agents; Databases, Factual; Furans; Intramolecular Transferases; Mic | 2004 |
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.
Topics: Animals; Antitubercular Agents; Biological Availability; Interferon-gamma; Mice; Mice, Inbred C57BL; | 2008 |
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Colony Count, Microbial; Female; Guinea Pigs; Isoniazid; Lung; Metro | 2008 |
Antituberculosis Treatment in a Patient with Celiac Disease.
Topics: Aged; Antitubercular Agents; Celiac Disease; Diarrhea; Diet, Gluten-Free; Drug Compounding; Drug Sub | 2018 |
[A case of pulmonary tuberculosis in which diagnosis was delayed because of prior treatment with fluoroquinolone and metronidazole].
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Female; Fluoroquinolones; Humans; Metronidazole | 2013 |
Dual infection with pulmonary tuberculosis and Lophomonas blattarum in India.
Topics: Antiprotozoal Agents; Antitubercular Agents; Bronchoalveolar Lavage; Ceftriaxone; Dose-Response Rela | 2015 |
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques.
Topics: Animals; Antiprotozoal Agents; Antitubercular Agents; Disease Models, Animal; Dose-Response Relation | 2012 |
Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.
Topics: Animals; Latent Tuberculosis; Metronidazole; Mycobacterium tuberculosis; Tuberculosis, Pulmonary | 2012 |
Case records of the Massachusetts General Hospital. Case 12-2006. A 37-year-old man with hemoptysis and a pulmonary infiltrate.
Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Hemoptysis; Humans; Lung; Lung Neoplasms; Mal | 2006 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Imm | 2008 |
Thoracic actinomycosis in an adolescent mimicking chest wall tumor or pulmonary tuberculosis.
Topics: Abscess; Actinomycosis; Anti-Infective Agents; Child; Combined Modality Therapy; Diagnosis, Differen | 2008 |
[Pulmonary amebiasis and tuberculosis association. Two case reports in Libreville, Gabon].
Topics: Adult; Alcoholism; Amebiasis; Anti-Infective Agents; Antitubercular Agents; Causality; Drug Therapy, | 2000 |
[Internal medicine conference: tuberculous lymphadenitis of the mediastinum (author's transl)].
Topics: Adult; Amebicides; Dysentery, Amebic; Humans; Male; Metronidazole; Tuberculosis, Hepatic; Tuberculos | 1976 |