Page last updated: 2024-10-31

metronidazole and Pulmonary Consumption

metronidazole has been researched along with Pulmonary Consumption in 15 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Metronidazole was given for a total of 3 weeks, and 2 weeks after discontinuation of metronidazole, she presented with recurrent chest pain and was diagnosed with active pulmonary tuberculosis."1.39[A case of pulmonary tuberculosis in which diagnosis was delayed because of prior treatment with fluoroquinolone and metronidazole]. ( Ema, R; Morioka, S; Nakamura, H; Sakurai, A; Tomita, K, 2013)
"Metronidazole (MTZ), which has activity only against anaerobic, nonreplicating bacteria, was as effective as either of these treatments in preventing reactivation of latent infection."1.38Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. ( Barry, CE; Dartois, V; Flynn, JL; Goodwin, MB; Janssen, C; Johnston, PJ; Klein, E; Lin, PL; Via, L, 2012)
"Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation."1.35Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. ( Basaraba, RJ; Brooks, EJ; Caraway, ML; Driver, ER; Hoff, DR; Lenaerts, AJ; Orme, IM; Peloquin, CA; Ryan, GJ, 2008)
"The mainstay of the treatment of actinomycosis remains to be a combination of abscess drainage as well as prolonged antibiotics such as penicillin."1.35Thoracic actinomycosis in an adolescent mimicking chest wall tumor or pulmonary tuberculosis. ( Chao, NS; Kwok, WK; Leung, MW; Wong, QH; Yeung, VH, 2008)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tangallapally, RP1
Yendapally, R1
Lee, RE2
Hevener, K1
Jones, VC1
Lenaerts, AJ3
McNeil, MR1
Wang, Y1
Franzblau, S1
Bitting, C1
Woolhiser, L1
Gruppo, V1
Marietta, KS1
Johnson, CM1
Orme, IM2
Hoff, DR1
Caraway, ML1
Brooks, EJ1
Driver, ER1
Ryan, GJ1
Peloquin, CA1
Basaraba, RJ1
Cerezo Lajas, A1
Caminero Luna, JA1
Rodríguez Guzmán, MDC1
de Miguel Díez, J1
Morioka, S1
Ema, R1
Sakurai, A1
Tomita, K1
Nakamura, H1
Verma, S1
Verma, G1
Singh, DV1
Mokta, J1
Negi, RS1
Jhobta, A1
Kanga, A1
Lin, PL2
Dartois, V1
Johnston, PJ1
Janssen, C1
Via, L1
Goodwin, MB1
Klein, E2
Barry, CE2
Flynn, JL2
Zhang, Y1
Gibbons, FK1
Branda, JA1
Shepard, JA1
Via, LE1
Ray, SM1
Carrillo, J1
Allen, SS1
Eum, SY1
Taylor, K1
Manjunatha, U1
Gonzales, J1
Lee, EG1
Park, SK1
Raleigh, JA1
Cho, SN1
McMurray, DN1
Yeung, VH1
Wong, QH1
Chao, NS1
Leung, MW1
Kwok, WK1
Flenley, DC1
Okomé-Nkoumou, M1
Kombila, M1
Weber, I1
Fabre, J1
Desai, CR1
Heera, S1
Patel, A1
Babrekar, AB1
Mahashur, AA1
Kamat, SR1

Reviews

1 review available for metronidazole and Pulmonary Consumption

ArticleYear
New drugs in respiratory disorders: II.
    British medical journal (Clinical research ed.), 1983, Mar-19, Volume: 286, Issue:6369

    Topics: Adult; Aged; Amantadine; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cephalosporins;

1983

Trials

1 trial available for metronidazole and Pulmonary Consumption

ArticleYear
Role of metronidazole in improving response and specific drug sensitivity in advanced pulmonary tuberculosis.
    The Journal of the Association of Physicians of India, 1989, Volume: 37, Issue:11

    Topics: Adolescent; Adult; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Male; Metronida

1989

Other Studies

13 other studies available for metronidazole and Pulmonary Consumption

ArticleYear
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents.
    Journal of medicinal chemistry, 2004, Oct-07, Volume: 47, Issue:21

    Topics: Amides; Animals; Antitubercular Agents; Databases, Factual; Furans; Intramolecular Transferases; Mic

2004
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4

    Topics: Animals; Antitubercular Agents; Biological Availability; Interferon-gamma; Mice; Mice, Inbred C57BL;

2008
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Animals; Antitubercular Agents; Colony Count, Microbial; Female; Guinea Pigs; Isoniazid; Lung; Metro

2008
Antituberculosis Treatment in a Patient with Celiac Disease.
    Archivos de bronconeumologia, 2018, Volume: 54, Issue:6

    Topics: Aged; Antitubercular Agents; Celiac Disease; Diarrhea; Diet, Gluten-Free; Drug Compounding; Drug Sub

2018
[A case of pulmonary tuberculosis in which diagnosis was delayed because of prior treatment with fluoroquinolone and metronidazole].
    Kekkaku : [Tuberculosis], 2013, Volume: 88, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Female; Fluoroquinolones; Humans; Metronidazole

2013
Dual infection with pulmonary tuberculosis and Lophomonas blattarum in India.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015, Volume: 19, Issue:3

    Topics: Antiprotozoal Agents; Antitubercular Agents; Bronchoalveolar Lavage; Ceftriaxone; Dose-Response Rela

2015
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-28, Volume: 109, Issue:35

    Topics: Animals; Antiprotozoal Agents; Antitubercular Agents; Disease Models, Animal; Dose-Response Relation

2012
Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-28, Volume: 109, Issue:35

    Topics: Animals; Latent Tuberculosis; Metronidazole; Mycobacterium tuberculosis; Tuberculosis, Pulmonary

2012
Case records of the Massachusetts General Hospital. Case 12-2006. A 37-year-old man with hemoptysis and a pulmonary infiltrate.
    The New England journal of medicine, 2006, Apr-20, Volume: 354, Issue:16

    Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Hemoptysis; Humans; Lung; Lung Neoplasms; Mal

2006
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
    Infection and immunity, 2008, Volume: 76, Issue:6

    Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Imm

2008
Thoracic actinomycosis in an adolescent mimicking chest wall tumor or pulmonary tuberculosis.
    Pediatric surgery international, 2008, Volume: 24, Issue:6

    Topics: Abscess; Actinomycosis; Anti-Infective Agents; Child; Combined Modality Therapy; Diagnosis, Differen

2008
[Pulmonary amebiasis and tuberculosis association. Two case reports in Libreville, Gabon].
    Bulletin de la Societe de pathologie exotique (1990), 2000, Volume: 93, Issue:4

    Topics: Adult; Alcoholism; Amebiasis; Anti-Infective Agents; Antitubercular Agents; Causality; Drug Therapy,

2000
[Internal medicine conference: tuberculous lymphadenitis of the mediastinum (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, Sep-07, Volume: 65, Issue:36

    Topics: Adult; Amebicides; Dysentery, Amebic; Humans; Male; Metronidazole; Tuberculosis, Hepatic; Tuberculos

1976