metronidazole has been researched along with Head and Neck Neoplasms in 17 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with penicillin G was very effective in the acute stage, and chronic administration of metronidazole prevented relapse of the disease." | 1.35 | An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis. ( Fujimuro, M; Jackson, M; Kawarabayashi, T; Kimura, T; Matsubara, E; Nakahata, N; Seino, Y; Shirahama, I; Shoji, M; Suzuki, C; Takamura, A; Tomiyama, M; Wakasaya, Y; Watanabe, M; Yamamoto-Watanabe, Y, 2009) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| "The paper summarizes the results of dynamic dose-fractionation combined with oxygen breathing at ambient pressure and metronidazole in head and neck, and uterine cervix cancer." | 1.27 | Dynamic dose-fractionation combined with oxygen breathing at ambient pressure and high-dose metronidazole in head and neck, and uterine cervix cancer. ( Boljesíková, E; Durkovský, J; Jancina, J; Kubovcáková, N; Siracká, E, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| George, R | 1 |
| Prasoona, TS | 1 |
| Kandasamy, R | 1 |
| Cherian, R | 1 |
| Celine, T | 1 |
| Jeba, J | 1 |
| Murali, S | 1 |
| Mathew, D | 1 |
| Wakasaya, Y | 1 |
| Watanabe, M | 1 |
| Tomiyama, M | 1 |
| Suzuki, C | 1 |
| Jackson, M | 1 |
| Fujimuro, M | 1 |
| Kimura, T | 1 |
| Seino, Y | 1 |
| Kawarabayashi, T | 1 |
| Yamamoto-Watanabe, Y | 1 |
| Matsubara, E | 1 |
| Shirahama, I | 1 |
| Takamura, A | 1 |
| Nakahata, N | 1 |
| Shoji, M | 1 |
| Goldobenko, GV | 1 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| Kiseleva, ES | 1 |
| Dar'ialova, SL | 1 |
| Stewart, DJ | 2 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Siracká, E | 1 |
| Kubovcáková, N | 1 |
| Durkovský, J | 1 |
| Jancina, J | 1 |
| Boljesíková, E | 1 |
| Murdoch, DA | 1 |
| Telfer, MR | 1 |
| Irvine, GH | 1 |
| Cripps, MC | 1 |
| Lamothe, A | 1 |
| Laframboise, G | 1 |
| Odell, P | 1 |
| Gerin-Lajoie, J | 1 |
| Strauss, M | 1 |
| Saccogna, PW | 1 |
| Allphin, AL | 1 |
| Dische, S | 1 |
| Lee, DJ | 1 |
| Wharam, MD | 1 |
| Kashima, H | 1 |
| Order, SE | 1 |
| Bernal Sprekelsen, M | 1 |
| Zan, W | 1 |
| Neumann, H | 1 |
| Hartmetz, G | 1 |
| Mann, W | 1 |
| Maurer, J | 1 |
| Gasparović, S | 1 |
| Virag, M | 1 |
| Robbins, KT | 1 |
| Byers, RM | 1 |
| Cole, R | 1 |
| Fainstein, V | 1 |
| Guillamondegui, OM | 1 |
| Schantz, SP | 1 |
| Weber, RS | 1 |
| Wolf, P | 1 |
| Goepfert, H | 1 |
| Brusis, T | 1 |
| Luckhaupt, H | 1 |
| Griebie, M | 1 |
| Adams, GL | 1 |
3 reviews available for metronidazole and Head and Neck Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H | 1984 |
Radiosensitizers in the treatment of squamous cell carcinoma of the head and neck.
Topics: Animals; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Hypoxia; | 1977 |
4 trials available for metronidazole and Head and Neck Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
Doxorubicin plus metronidazole in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 1993 |
[Perioperative short-term preventive antibiotics in head-neck surgery].
Topics: Cefotiam; Clinical Trials as Topic; Female; Head and Neck Neoplasms; Humans; Male; Metronidazole; Mi | 1990 |
Wound prophylaxis with metronidazole in head and neck surgical oncology.
Topics: Bacteria, Anaerobic; Bacterial Infections; Cefazolin; Drug Therapy, Combination; Head and Neck Neopl | 1988 |
11 other studies available for metronidazole and Head and Neck Neoplasms
| Article | Year |
|---|---|
Improving malodour management in advanced cancer: a 10-year retrospective study of topical, oral and maintenance metronidazole.
Topics: Administration, Cutaneous; Administration, Oral; Anti-Infective Agents; Female; Head and Neck Neopla | 2017 |
An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.
Topics: Anti-Bacterial Agents; Chronic Disease; Gallium Radioisotopes; Head and Neck Neoplasms; Humans; Lymp | 2009 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Dynamic dose-fractionation combined with oxygen breathing at ambient pressure and high-dose metronidazole in head and neck, and uterine cervix cancer.
Topics: Cobalt Radioisotopes; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Metronidaz | 1983 |
Audit of antibiotic policy and wound infection in neck surgery.
Topics: Anti-Bacterial Agents; Cefuroxime; Clinical Protocols; Drug Therapy, Combination; Head and Neck Neop | 1993 |
Cephazolin and metronidazole prophylaxis in head and neck surgery.
Topics: Antibiotic Prophylaxis; Antitrichomonal Agents; Black or African American; Cefazolin; Cephalosporins | 1997 |
Short course high fractional dose irradiation in advanced and recurrent head and neck cancer.
Topics: Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Metronidazole; Mucous Membr | 1979 |
[Perioperative prophylaxis in patients with head and neck tumors].
Topics: Bacterial Infections; Cefuroxime; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans | 1991 |
[Comparison of a combination of clindamycin/gentamycin with metronidazole/gentamycin in surgery of the head and neck].
Topics: Clindamycin; Drug Therapy, Combination; Gentamicins; Head and Neck Neoplasms; Humans; Infection Cont | 1988 |
[Anaerobic infections in ulcerating tumors of the head and neck. A contribution to the problem of odors].
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Clindamycin; Head and Neck Neopla | 1986 |
Clostridium difficile colitis following head and neck surgery. Report of cases.
Topics: Aged; Anti-Bacterial Agents; Clostridium Infections; Diarrhea; Enterocolitis, Pseudomembranous; Head | 1985 |