metronidazole has been researched along with Acute Necrotizing Pancreatitis in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical course and death rate in acute necrotizing pancreatitis (ANP) are largely determined by septic complications as part of bacterial invasion of the necrotic tissues." | 2.68 | [Antibiotic use in necrotizing pancreatitis. Results of a controlled study]. ( Beger, HG; Isenmann, R; Meyer, H; Schwarz, M, 1997) |
| "The clinical course in acute necrotizing pancreatitis is mainly determined by bacterial infection of pancreatic and peripancreatic necrosis." | 1.34 | Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. ( Beger, HG; Gansauge, F; Isenmann, R; Kriese, D; Poch, B; Rozdzinski, E; Schwarz, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ignatavicius, P | 1 |
| Vitkauskiene, A | 1 |
| Pundzius, J | 1 |
| Dambrauskas, Z | 1 |
| Barauskas, G | 1 |
| Isenmann, R | 3 |
| Rünzi, M | 1 |
| Kron, M | 1 |
| Kahl, S | 1 |
| Kraus, D | 1 |
| Jung, N | 1 |
| Maier, L | 1 |
| Malfertheiner, P | 1 |
| Goebell, H | 1 |
| Beger, HG | 3 |
| Gülçubuk, A | 1 |
| Sönmez, K | 1 |
| Gürel, A | 1 |
| Altunatmaz, K | 1 |
| Gürler, N | 1 |
| Aydin, S | 1 |
| Oksüz, L | 1 |
| Uzun, H | 1 |
| Güzel, O | 1 |
| Schwarz, M | 2 |
| Poch, B | 1 |
| Kriese, D | 1 |
| Rozdzinski, E | 1 |
| Gansauge, F | 1 |
| Meyer, H | 1 |
| Ammori, BJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Trial of Standard vs. Enhanced Hydration in Patients With a Diagnosis of Acute Pancreatitis Within the First Hour of the Diagnosis[NCT02709044] | Phase 2/Phase 3 | 903 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial.
Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Double-Blind Method; Female; Gram-Negative Bacter | 2004 |
[Antibiotic use in necrotizing pancreatitis. Results of a controlled study].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Biopsy, Needle; Drug Th | 1997 |
4 other studies available for metronidazole and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Effects of prophylactic antibiotics in acute pancreatitis.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Infections; Ciprofloxacin; Deb | 2012 |
Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination.
Topics: Animals; Anti-Infective Agents; Antioxidants; Bacterial Translocation; Ciprofloxacin; Curcumin; Dise | 2005 |
Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats.
Topics: Animals; Anti-Infective Agents; Bacterial Infections; Cholagogues and Choleretics; Ciprofloxacin; Di | 2007 |
Laparoscopic transgastric pancreatic necrosectomy for infected pancreatic necrosis.
Topics: Aged; Amylases; Anti-Bacterial Agents; Blood Loss, Surgical; Ciprofloxacin; Debridement; Enterobacte | 2002 |