metronidazole has been researched along with Zoonoses in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Zoonoses: Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amebiasis is a disease caused by the protozoan parasite Entamoeba histolytica, which mainly shows symptoms of acute diarrhea, dysentery, amebic colitis, and amebic liver abscesses." | 2.72 | Review of zoonotic amebiasis: Epidemiology, clinical signs, diagnosis, treatment, prevention and control. ( Cui, Z; Li, J; Li, X; Zhang, L, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Cui, Z | 1 |
| Li, X | 1 |
| Zhang, L | 1 |
| Miller, DC | 1 |
| Fung, M | 1 |
| Carbo, A | 1 |
| Nelson, SP | 1 |
| Lin, PL | 1 |
| Miller, J | 1 |
| Katz, BZ | 1 |
| Gonzalez-Crussi, F | 1 |
| Garcia-Laverde, A | 1 |
| de Bonilla, L | 1 |
| Turner, JA | 1 |
2 reviews available for metronidazole and Zoonoses
| Article | Year |
|---|---|
Review of zoonotic amebiasis: Epidemiology, clinical signs, diagnosis, treatment, prevention and control.
Topics: Amebiasis; Animals; Antiprotozoal Agents; Diarrhea; Dysentery, Amebic; Entamoeba histolytica; Humans | 2021 |
Giardiasis and infections with Dientamoeba fragilis.
Topics: Adult; Amebiasis; Animals; Cats; Child; Child, Preschool; Dientamoeba; Dientamoebiasis; Dogs; Female | 1985 |
1 trial available for metronidazole and Zoonoses
| Article | Year |
|---|---|
Clinical trials with metronidazole in human balantidiasis.
Topics: Adolescent; Adult; Animals; Balantidiasis; Balantidium; Child; Child, Preschool; Dose-Response Relat | 1975 |
2 other studies available for metronidazole and Zoonoses
| Article | Year |
|---|---|
A Furry Friend's Dirty Mouth: Brain Abscess Due to Aggregatibacter (Haemophilus) aphrophilus.
Topics: Adult; Aggregatibacter aphrophilus; Animals; Anti-Bacterial Agents; Brain Abscess; Ceftriaxone; Dogs | 2017 |
Cryptosporidia enterocolitis in an immunocompetent infant treated with paromomycin.
Topics: Animals; Anti-Infective Agents; Biopsy; Cryptosporidiosis; Duodenum; Enterocolitis; Humans; Immunoco | 1999 |