Page last updated: 2024-10-31

metronidazole and Ache

metronidazole has been researched along with Ache in 27 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"This multinational, multicentre, prospective, randomised, double blind, parallel group, non-inferiority study compared the efficacy and safety of moxifloxacin monotherapy with ofloxacin plus metronidazole in women with uncomplicated pelvic inflammatory disease."9.12Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. ( Alefelder, M; Arvis, P; Cronjé, HS; Kureishi, A; Paszkowski, T; Rakoczi, I; Reimnitz, P; Ross, JD; Vildaite, D, 2006)
"An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw."7.96[An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020)
"A 53-year-old male patient developed insidious onset of length-dependent painful neuropathy on a background of encephalopathy during prolonged treatment with metronidazole for a cumulative dose of 146 g in 88 days."7.77Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. ( Chao, CC; Chen, CC; Chen, YF; Hsieh, ST; Liou, HH; Tan, CH, 2011)
"Both topical and oral metronidazole have been shown to reduce pain after excisional hemorrhoidectomy."5.51Topical Versus Oral Metronidazole After Excisional Hemorrhoidectomy: A Double-Blind Randomized Controlled Trial. ( Barazanchi, AWH; Hill, AG; MacCormick, AD; MacFater, WS; Sammour, T; Svirskis, D; Xia, W, 2022)
"Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole."5.24Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management. ( Amii, R; DeUgarte, DA; Jude, CM; Krishnadasan, A; Moran, GJ; Morim, A; Mower, WR; Pathmarajah, K; Saltzman, DJ; Talan, DA; Wu, JX, 2017)
"This multinational, multicentre, prospective, randomised, double blind, parallel group, non-inferiority study compared the efficacy and safety of moxifloxacin monotherapy with ofloxacin plus metronidazole in women with uncomplicated pelvic inflammatory disease."5.12Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. ( Alefelder, M; Arvis, P; Cronjé, HS; Kureishi, A; Paszkowski, T; Rakoczi, I; Reimnitz, P; Ross, JD; Vildaite, D, 2006)
"An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw."3.96[An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020)
"A 53-year-old male patient developed insidious onset of length-dependent painful neuropathy on a background of encephalopathy during prolonged treatment with metronidazole for a cumulative dose of 146 g in 88 days."3.77Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. ( Chao, CC; Chen, CC; Chen, YF; Hsieh, ST; Liou, HH; Tan, CH, 2011)
"In this case of painful legs and moving toes the essential characteristics were to be secondary to a neuropathy due to vincristine and metronidazole."3.67[Painful legs and moving toes. A drug-induced case]. ( Gastaut, JL, 1986)
"Perianal pain was assessed on a visual analogue scale."2.75Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease. ( Burt, C; Carapeti, E; Durdey, P; Maeda, Y; Mayberry, J; Moshkovska, T; Ng, SC; Rao, PK; Stone, CD; Torkington, J; Vaizey, CJ, 2010)
"Fingating wounds always present a management challenge."2.43Assessment and management of fungating wounds: a review. ( Wilson, V, 2005)
"Metronidazole is an effective treatment and none of the patients required an invasive method for diagnosis or treatment."1.31Clinical characteristic of amoebic liver abscesses in the North of Iraq. ( Baban, FA, 2000)
"Wounds with necrotising fasciitis are often malodorous and produce copious exudate."1.31Management of a heavily exuding, painful wound with necrotising subcutaneous infection. ( Fairhurst, J; Ovens, N, 2002)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19909 (33.33)18.7374
1990's2 (7.41)18.2507
2000's7 (25.93)29.6817
2010's7 (25.93)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Xia, W1
Barazanchi, AWH1
MacFater, WS1
MacCormick, AD1
Svirskis, D1
Sammour, T1
Hill, AG1
Röttgering, JG1
Herderscheê, D1
Lionarons, DA1
de Vries, PJ1
Carter, C1
Viveash, S1
Li, HZ1
Cheng, YS1
Liu, XF1
Zhu, XN1
Woods, JL1
Scurlock, AM1
Hensel, DJ1
Talan, DA1
Saltzman, DJ1
Mower, WR1
Krishnadasan, A1
Jude, CM1
Amii, R1
DeUgarte, DA1
Wu, JX1
Pathmarajah, K1
Morim, A1
Moran, GJ1
Tan, CH1
Chen, YF1
Chen, CC1
Chao, CC1
Liou, HH1
Hsieh, ST1
Maeda, Y1
Ng, SC1
Durdey, P1
Burt, C1
Torkington, J1
Rao, PK1
Mayberry, J1
Moshkovska, T1
Stone, CD1
Carapeti, E1
Vaizey, CJ1
Lawford, AM1
Scott, K1
Lust, K1
Bale, S1
Tebbie, N1
Price, P1
Wilson, V1
Ross, JD1
Cronjé, HS1
Paszkowski, T1
Rakoczi, I1
Vildaite, D1
Kureishi, A1
Alefelder, M1
Arvis, P1
Reimnitz, P1
Mekrut-Barrows, C1
Obbens, EA1
Kim, JH1
Thaler, H1
Deck, MD1
Posner, JB1
Strum, WB1
Hayes, JG1
Hosking, SW1
Ling, TK1
Chung, SC1
Yung, MY1
Cheng, AF1
Sung, JJ1
Li, AK1
Baban, FA1
Dancer, SJ1
McNAIR, D1
Finn, P1
Kolsto, AB1
Ovens, N1
Fairhurst, J1
Kerlin, P1
Ratnaike, RN1
Butler, R1
Grant, NG1
Gastaut, JL1
Pittman, F1
Westphal, M1
Shookhoff, HB1
Katz, M1
Perry, W1
Goldsmid, JM1
Gelfand, M2
Holmes, GK1
Boyt, W1
Mackenzie, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.[NCT04273997]Phase 280 participants (Anticipated)Interventional2021-10-01Not yet recruiting
Phase III Study to Evaluate the Effect of 10% Metronidazole Ointment, Applied Topically Three Times a Day in and Around the Anus and the Change in Perianal Crohn's Disease Activity[NCT00509639]Phase 374 participants (Actual)Interventional2005-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metronidazole and Ache

ArticleYear
Assessment and management of fungating wounds: a review.
    British journal of community nursing, 2005, Volume: 10, Issue:3

    Topics: Administration, Topical; Alginates; Anti-Infective Agents; Bandages; Charcoal; Community Health Nurs

2005

Trials

8 trials available for metronidazole and Ache

ArticleYear
Topical Versus Oral Metronidazole After Excisional Hemorrhoidectomy: A Double-Blind Randomized Controlled Trial.
    Diseases of the colon and rectum, 2022, 11-01, Volume: 65, Issue:11

    Topics: Adult; Hemorrhoidectomy; Humans; Metronidazole; Ointments; Pain; Prospective Studies; Retrospective

2022
Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management.
    Annals of emergency medicine, 2017, Volume: 70, Issue:1

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendici

2017
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
    The British journal of surgery, 2010, Volume: 97, Issue:9

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me

2010
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
    The British journal of surgery, 2010, Volume: 97, Issue:9

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me

2010
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
    The British journal of surgery, 2010, Volume: 97, Issue:9

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me

2010
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
    The British journal of surgery, 2010, Volume: 97, Issue:9

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me

2010
A topical metronidazole gel used to treat malodorous wounds.
    British journal of nursing (Mark Allen Publishing), 2004, Jun-10, Volume: 13, Issue:11

    Topics: Administration, Cutaneous; Anti-Infective Agents; Attitude of Health Personnel; Attitude to Health;

2004
Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial.
    Sexually transmitted infections, 2006, Volume: 82, Issue:6

    Topics: Administration, Oral; Adult; Anti-Infective Agents; Aza Compounds; Double-Blind Method; Drug Therapy

2006
Metronidazole as a radiation enhancer in the treatment of metastatic epidural spinal cord compression.
    Journal of neuro-oncology, 1984, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Middle Aged;

1984
Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trial.
    Lancet (London, England), 1994, Feb-26, Volume: 343, Issue:8896

    Topics: Adult; Aged; Antacids; Biopsy; Drug Resistance, Microbial; Drug Therapy, Combination; Duodenal Ulcer

1994
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
    Le Chirurgien-dentiste de France, 1991, Jan-17, Volume: 61, Issue:548

    Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth

1991

Other Studies

18 other studies available for metronidazole and Ache

ArticleYear
[An unvaccinated man with a painful arm and jaw].
    Nederlands tijdschrift voor geneeskunde, 2020, 01-09, Volume: 164

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Arm; Clostridium tetani; Humans; Jaw; Male; Metronidazole;

2020
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
    British journal of nursing (Mark Allen Publishing), 2017, May-11, Volume: 26, Issue:9

    Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic

2017
Metronidazole for Posthemorrhoidectomy Pain: Does No Statistical Significance Mean Insignificant Effect on Pain Relief?
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:9

    Topics: Hemorrhoids; Humans; Metronidazole; Pain; Pain Management; Pain Measurement; Pain, Postoperative

2017
Pelvic inflammatory disease in the adolescent: understanding diagnosis and treatment as a health care provider.
    Pediatric emergency care, 2013, Volume: 29, Issue:6

    Topics: Adolescent; Anti-Bacterial Agents; Arkansas; Ceftriaxone; Centers for Disease Control and Prevention

2013
Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity.
    Journal of neurology, neurosurgery, and psychiatry, 2011, Volume: 82, Issue:4

    Topics: Denervation; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Middle Aged; Neural Conduction

2011
A case of massive vulvar oedema due to septic pubic symphysitis complicating pregnancy.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2010, Volume: 50, Issue:6

    Topics: Adult; Anti-Bacterial Agents; C-Reactive Protein; Ceftriaxone; Edema; Female; Fever; Gentamicins; Hu

2010
Softening the pain of cancer-related wounds.
    Ostomy/wound management, 2006, Volume: 52, Issue:9

    Topics: Aged; Female; Humans; Metronidazole; Neoplasms; Pain; Pain Management; Wounds and Injuries

2006
Persistent pain, fever after a trip to Mexico.
    Hospital practice (Office ed.), 1984, Volume: 19, Issue:10

    Topics: Adult; Diagnosis, Differential; Diarrhea; Female; Fever; Humans; Iodoquinol; Liver Abscess, Amebic;

1984
Amoebic liver abscess: clinical presentation and diagnosis.
    The Australian and New Zealand journal of surgery, 1980, Volume: 50, Issue:5

    Topics: Abdomen; Adult; Aged; Anorexia; Body Weight; Female; Fever; Humans; Liver Abscess, Amebic; Male; Met

1980
Clinical characteristic of amoebic liver abscesses in the North of Iraq.
    Saudi medical journal, 2000, Volume: 21, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Diagnosis, Differential; Fever; Hepatomegaly; Humans

2000
Bacillus cereus cellulitis from contaminated heroin.
    Journal of medical microbiology, 2002, Volume: 51, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Bacillus cereus; Cellulitis; Forearm; Genotype; Gentamicins; Heroin; H

2002
Management of a heavily exuding, painful wound with necrotising subcutaneous infection.
    Journal of wound care, 2002, Volume: 11, Issue:1

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasciiti

2002
Prevalence of Giardiasis: a study at upper-gastrointestinal endoscopy.
    The American journal of digestive diseases, 1978, Volume: 23, Issue:10

    Topics: Abdomen; Adult; Aged; Australia; Diagnosis, Differential; Gastric Juice; Gastroscopy; Giardia; Giard

1978
[Painful legs and moving toes. A drug-induced case].
    Revue neurologique, 1986, Volume: 142, Issue:6-7

    Topics: Adult; Drug Interactions; Humans; Leg; Male; Metronidazole; Movement Disorders; Pain; Peripheral Ner

1986
S.M.O.N. and inflammation of the colon.
    Lancet (London, England), 1973, Sep-08, Volume: 2, Issue:7828

    Topics: Abdomen; Amblyopia; Child; Colitis; Diarrhea; Female; Humans; Intestinal Absorption; Iodoquinol; Kid

1973
Letter: S.M.O.N. and inflammation of the colon.
    Lancet (London, England), 1973, Nov-10, Volume: 2, Issue:7837

    Topics: Abdomen; Adult; Amebiasis; Child; Colitis; Diarrhea; Drug Evaluation; Humans; Iodoquinol; Metronidaz

1973
Human fascioliasis in Rhodesia. Report of a case with a liver abscess.
    The Journal of tropical medicine and hygiene, 1972, Volume: 75, Issue:11

    Topics: Abdomen; Biopsy; Child; Drainage; Emetine; Fasciola; Fascioliasis; Female; Humans; Liver; Liver Absc

1972
A study to investigate the pathogenicity of a parasite resembling Acanthocheilonema perstans.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1969, Volume: 63, Issue:4

    Topics: Diethylcarbamazine; Dipetalonema; Eosinophilia; Humans; Joint Diseases; Metronidazole; Nematode Infe

1969