metronidazole has been researched along with Ache in 27 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This multinational, multicentre, prospective, randomised, double blind, parallel group, non-inferiority study compared the efficacy and safety of moxifloxacin monotherapy with ofloxacin plus metronidazole in women with uncomplicated pelvic inflammatory disease." | 9.12 | Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. ( Alefelder, M; Arvis, P; Cronjé, HS; Kureishi, A; Paszkowski, T; Rakoczi, I; Reimnitz, P; Ross, JD; Vildaite, D, 2006) |
| "An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw." | 7.96 | [An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020) |
| "A 53-year-old male patient developed insidious onset of length-dependent painful neuropathy on a background of encephalopathy during prolonged treatment with metronidazole for a cumulative dose of 146 g in 88 days." | 7.77 | Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. ( Chao, CC; Chen, CC; Chen, YF; Hsieh, ST; Liou, HH; Tan, CH, 2011) |
| "Both topical and oral metronidazole have been shown to reduce pain after excisional hemorrhoidectomy." | 5.51 | Topical Versus Oral Metronidazole After Excisional Hemorrhoidectomy: A Double-Blind Randomized Controlled Trial. ( Barazanchi, AWH; Hill, AG; MacCormick, AD; MacFater, WS; Sammour, T; Svirskis, D; Xia, W, 2022) |
| "Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole." | 5.24 | Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management. ( Amii, R; DeUgarte, DA; Jude, CM; Krishnadasan, A; Moran, GJ; Morim, A; Mower, WR; Pathmarajah, K; Saltzman, DJ; Talan, DA; Wu, JX, 2017) |
| "This multinational, multicentre, prospective, randomised, double blind, parallel group, non-inferiority study compared the efficacy and safety of moxifloxacin monotherapy with ofloxacin plus metronidazole in women with uncomplicated pelvic inflammatory disease." | 5.12 | Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial. ( Alefelder, M; Arvis, P; Cronjé, HS; Kureishi, A; Paszkowski, T; Rakoczi, I; Reimnitz, P; Ross, JD; Vildaite, D, 2006) |
| "An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw." | 3.96 | [An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020) |
| "A 53-year-old male patient developed insidious onset of length-dependent painful neuropathy on a background of encephalopathy during prolonged treatment with metronidazole for a cumulative dose of 146 g in 88 days." | 3.77 | Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. ( Chao, CC; Chen, CC; Chen, YF; Hsieh, ST; Liou, HH; Tan, CH, 2011) |
| "In this case of painful legs and moving toes the essential characteristics were to be secondary to a neuropathy due to vincristine and metronidazole." | 3.67 | [Painful legs and moving toes. A drug-induced case]. ( Gastaut, JL, 1986) |
| "Perianal pain was assessed on a visual analogue scale." | 2.75 | Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease. ( Burt, C; Carapeti, E; Durdey, P; Maeda, Y; Mayberry, J; Moshkovska, T; Ng, SC; Rao, PK; Stone, CD; Torkington, J; Vaizey, CJ, 2010) |
| "Fingating wounds always present a management challenge." | 2.43 | Assessment and management of fungating wounds: a review. ( Wilson, V, 2005) |
| "Metronidazole is an effective treatment and none of the patients required an invasive method for diagnosis or treatment." | 1.31 | Clinical characteristic of amoebic liver abscesses in the North of Iraq. ( Baban, FA, 2000) |
| "Wounds with necrotising fasciitis are often malodorous and produce copious exudate." | 1.31 | Management of a heavily exuding, painful wound with necrotising subcutaneous infection. ( Fairhurst, J; Ovens, N, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, W | 1 |
| Barazanchi, AWH | 1 |
| MacFater, WS | 1 |
| MacCormick, AD | 1 |
| Svirskis, D | 1 |
| Sammour, T | 1 |
| Hill, AG | 1 |
| Röttgering, JG | 1 |
| Herderscheê, D | 1 |
| Lionarons, DA | 1 |
| de Vries, PJ | 1 |
| Carter, C | 1 |
| Viveash, S | 1 |
| Li, HZ | 1 |
| Cheng, YS | 1 |
| Liu, XF | 1 |
| Zhu, XN | 1 |
| Woods, JL | 1 |
| Scurlock, AM | 1 |
| Hensel, DJ | 1 |
| Talan, DA | 1 |
| Saltzman, DJ | 1 |
| Mower, WR | 1 |
| Krishnadasan, A | 1 |
| Jude, CM | 1 |
| Amii, R | 1 |
| DeUgarte, DA | 1 |
| Wu, JX | 1 |
| Pathmarajah, K | 1 |
| Morim, A | 1 |
| Moran, GJ | 1 |
| Tan, CH | 1 |
| Chen, YF | 1 |
| Chen, CC | 1 |
| Chao, CC | 1 |
| Liou, HH | 1 |
| Hsieh, ST | 1 |
| Maeda, Y | 1 |
| Ng, SC | 1 |
| Durdey, P | 1 |
| Burt, C | 1 |
| Torkington, J | 1 |
| Rao, PK | 1 |
| Mayberry, J | 1 |
| Moshkovska, T | 1 |
| Stone, CD | 1 |
| Carapeti, E | 1 |
| Vaizey, CJ | 1 |
| Lawford, AM | 1 |
| Scott, K | 1 |
| Lust, K | 1 |
| Bale, S | 1 |
| Tebbie, N | 1 |
| Price, P | 1 |
| Wilson, V | 1 |
| Ross, JD | 1 |
| Cronjé, HS | 1 |
| Paszkowski, T | 1 |
| Rakoczi, I | 1 |
| Vildaite, D | 1 |
| Kureishi, A | 1 |
| Alefelder, M | 1 |
| Arvis, P | 1 |
| Reimnitz, P | 1 |
| Mekrut-Barrows, C | 1 |
| Obbens, EA | 1 |
| Kim, JH | 1 |
| Thaler, H | 1 |
| Deck, MD | 1 |
| Posner, JB | 1 |
| Strum, WB | 1 |
| Hayes, JG | 1 |
| Hosking, SW | 1 |
| Ling, TK | 1 |
| Chung, SC | 1 |
| Yung, MY | 1 |
| Cheng, AF | 1 |
| Sung, JJ | 1 |
| Li, AK | 1 |
| Baban, FA | 1 |
| Dancer, SJ | 1 |
| McNAIR, D | 1 |
| Finn, P | 1 |
| Kolsto, AB | 1 |
| Ovens, N | 1 |
| Fairhurst, J | 1 |
| Kerlin, P | 1 |
| Ratnaike, RN | 1 |
| Butler, R | 1 |
| Grant, NG | 1 |
| Gastaut, JL | 1 |
| Pittman, F | 1 |
| Westphal, M | 1 |
| Shookhoff, HB | 1 |
| Katz, M | 1 |
| Perry, W | 1 |
| Goldsmid, JM | 1 |
| Gelfand, M | 2 |
| Holmes, GK | 1 |
| Boyt, W | 1 |
| Mackenzie, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.[NCT04273997] | Phase 2 | 80 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| Phase III Study to Evaluate the Effect of 10% Metronidazole Ointment, Applied Topically Three Times a Day in and Around the Anus and the Change in Perianal Crohn's Disease Activity[NCT00509639] | Phase 3 | 74 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Ache
| Article | Year |
|---|---|
Assessment and management of fungating wounds: a review.
Topics: Administration, Topical; Alginates; Anti-Infective Agents; Bandages; Charcoal; Community Health Nurs | 2005 |
8 trials available for metronidazole and Ache
| Article | Year |
|---|---|
Topical Versus Oral Metronidazole After Excisional Hemorrhoidectomy: A Double-Blind Randomized Controlled Trial.
Topics: Adult; Hemorrhoidectomy; Humans; Metronidazole; Ointments; Pain; Prospective Studies; Retrospective | 2022 |
Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendici | 2017 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
A topical metronidazole gel used to treat malodorous wounds.
Topics: Administration, Cutaneous; Anti-Infective Agents; Attitude of Health Personnel; Attitude to Health; | 2004 |
Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Aza Compounds; Double-Blind Method; Drug Therapy | 2006 |
Metronidazole as a radiation enhancer in the treatment of metastatic epidural spinal cord compression.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Middle Aged; | 1984 |
Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trial.
Topics: Adult; Aged; Antacids; Biopsy; Drug Resistance, Microbial; Drug Therapy, Combination; Duodenal Ulcer | 1994 |
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth | 1991 |
18 other studies available for metronidazole and Ache
| Article | Year |
|---|---|
[An unvaccinated man with a painful arm and jaw].
Topics: Aged, 80 and over; Anti-Bacterial Agents; Arm; Clostridium tetani; Humans; Jaw; Male; Metronidazole; | 2020 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
Metronidazole for Posthemorrhoidectomy Pain: Does No Statistical Significance Mean Insignificant Effect on Pain Relief?
Topics: Hemorrhoids; Humans; Metronidazole; Pain; Pain Management; Pain Measurement; Pain, Postoperative | 2017 |
Pelvic inflammatory disease in the adolescent: understanding diagnosis and treatment as a health care provider.
Topics: Adolescent; Anti-Bacterial Agents; Arkansas; Ceftriaxone; Centers for Disease Control and Prevention | 2013 |
Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity.
Topics: Denervation; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Middle Aged; Neural Conduction | 2011 |
A case of massive vulvar oedema due to septic pubic symphysitis complicating pregnancy.
Topics: Adult; Anti-Bacterial Agents; C-Reactive Protein; Ceftriaxone; Edema; Female; Fever; Gentamicins; Hu | 2010 |
Softening the pain of cancer-related wounds.
Topics: Aged; Female; Humans; Metronidazole; Neoplasms; Pain; Pain Management; Wounds and Injuries | 2006 |
Persistent pain, fever after a trip to Mexico.
Topics: Adult; Diagnosis, Differential; Diarrhea; Female; Fever; Humans; Iodoquinol; Liver Abscess, Amebic; | 1984 |
Amoebic liver abscess: clinical presentation and diagnosis.
Topics: Abdomen; Adult; Aged; Anorexia; Body Weight; Female; Fever; Humans; Liver Abscess, Amebic; Male; Met | 1980 |
Clinical characteristic of amoebic liver abscesses in the North of Iraq.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Diagnosis, Differential; Fever; Hepatomegaly; Humans | 2000 |
Bacillus cereus cellulitis from contaminated heroin.
Topics: Adult; Anti-Bacterial Agents; Bacillus cereus; Cellulitis; Forearm; Genotype; Gentamicins; Heroin; H | 2002 |
Management of a heavily exuding, painful wound with necrotising subcutaneous infection.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasciiti | 2002 |
Prevalence of Giardiasis: a study at upper-gastrointestinal endoscopy.
Topics: Abdomen; Adult; Aged; Australia; Diagnosis, Differential; Gastric Juice; Gastroscopy; Giardia; Giard | 1978 |
[Painful legs and moving toes. A drug-induced case].
Topics: Adult; Drug Interactions; Humans; Leg; Male; Metronidazole; Movement Disorders; Pain; Peripheral Ner | 1986 |
S.M.O.N. and inflammation of the colon.
Topics: Abdomen; Amblyopia; Child; Colitis; Diarrhea; Female; Humans; Intestinal Absorption; Iodoquinol; Kid | 1973 |
Letter: S.M.O.N. and inflammation of the colon.
Topics: Abdomen; Adult; Amebiasis; Child; Colitis; Diarrhea; Drug Evaluation; Humans; Iodoquinol; Metronidaz | 1973 |
Human fascioliasis in Rhodesia. Report of a case with a liver abscess.
Topics: Abdomen; Biopsy; Child; Drainage; Emetine; Fasciola; Fascioliasis; Female; Humans; Liver; Liver Absc | 1972 |
A study to investigate the pathogenicity of a parasite resembling Acanthocheilonema perstans.
Topics: Diethylcarbamazine; Dipetalonema; Eosinophilia; Humans; Joint Diseases; Metronidazole; Nematode Infe | 1969 |