metronidazole has been researched along with Cancer of Intestines in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dingemanse, C | 1 |
| Belzer, C | 1 |
| van Hijum, SA | 1 |
| Günthel, M | 1 |
| Salvatori, D | 1 |
| den Dunnen, JT | 1 |
| Kuijper, EJ | 1 |
| Devilee, P | 1 |
| de Vos, WM | 1 |
| van Ommen, GB | 1 |
| Robanus-Maandag, EC | 1 |
| Vallance, S | 1 |
| Jones, B | 1 |
| Arabi, Y | 1 |
| Keighley, MR | 1 |
| Goldsmith, RS | 1 |
| Horiki, N | 1 |
| Kaneda, Y | 1 |
| Maruyama, M | 1 |
| Fujita, Y | 1 |
| Tachibana, H | 1 |
| Werner, GT | 1 |
| Pain, AK | 1 |
1 trial available for metronidazole and Cancer of Intestines
| Article | Year |
|---|---|
Importance of adding neomycin to metronidazole for bowel preparation.
Topics: Administration, Oral; Aged; Clinical Trials as Topic; Colon; Double-Blind Method; Drug Therapy, Comb | 1980 |
5 other studies available for metronidazole and Cancer of Intestines
| Article | Year |
|---|---|
Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Carcinogenesis; Clarithromycin; Drug Therapy, Combinati | 2015 |
Amebic liver abscess.
Topics: Diagnosis, Differential; Humans; Intestinal Neoplasms; Intestine, Large; Liver Abscess, Amebic; Male | 1980 |
Intestinal blockage by carcinoma and Blastocystis hominis infection.
Topics: Adolescent; Adult; Aged; Animals; Antitrichomonal Agents; Blastocystis hominis; Blastocystis Infecti | 1999 |
[Diagnosis of amebiasis].
Topics: Adult; Amebiasis; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; Emetine; Humans | 1979 |
Amoebic granuloma of the large bowel.
Topics: Adult; Amebiasis; Barium; Biopsy; Colonic Diseases; Diagnosis, Differential; Enema; Granuloma; Human | 1971 |