Benign Chronic Pemphigus

An autosomal dominantly inherited skin disorder characterized by recurrent eruptions of vesicles and BULLAE mainly on the neck, axillae, and groin. Mutations in the ATP2C1 gene (encoding the secretory pathway Ca2++/Mn2++ ATPase 1 (SPCA1)) cause this disease. It is clinically and histologically similar to DARIER DISEASE - both have abnormal, unstable DESMOSOMES between KERATINOCYTES and defective CALCIUM-TRANSPORTING ATPASES. It is unrelated to PEMPHIGUS VULGARIS though it closely resembles that disease.

Synonym
Pemphigus, Benign Familial
Familial Benign Chronic Pemphigus
Hailey-Hailey Disease
Chronic Benign Familial Pemphigus
Benign Chronic Pemphigus

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (4.20)	23.3326
1990's	19 (13.29)	12.5806
2000's	43 (30.07)	18.1394
2010's	52 (36.36)	28.8240
2020's	23 (16.08)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	4	0
quinacrine	low	1	0
salicylic acid	low	2	0
aminocaproic acid	low	1	0
cytosine	low	1	0
glycine	low	1	0
niacinamide	low	2	0
thymine	low	1	0
azathioprine	low	2	0
camostat	low	1	0
dapsone	low	2	0
fluorouracil	low	1	0
gabexate	low	1	0
merbromin	low	1	0
metronidazole	low	1	0
sulfamethoxypyridazine	low	1	0
thalidomide	low	8	0
prednisolone	low	3	0
prednisone	low	2	0
aspartic acid	low	1	0
fluocinolone acetonide	low	1	0
arginine	low	1	0
betamethasone	low	3	0
glycopyrrolate	low	4	0
c.i. 42510	low	1	0
erythromycin	low	1	0
zinc oxide	low	1	0
vancomycin	low	1	0
methylprednisolone hemisuccinate	low	1	0
manganese	low	4	0
gold	low	1	0
hypochlorous acid	low	1	0
silver nitrate	low	1	0
triamcinolone	low	2	0
imiquimod	low	1	0
dexamethasone dipropionate	medium	1	1
methyl levulinate	medium	1	1
clarithromycin	low	2	0
methotrexate	low	4	0
betamethasone-17,21-dipropionate	low	1	0
cinacalcet	low	1	0
methyl 5-aminolevulinate	low	1	0
cortisone	low	1	0
griseofulvin	low	1	0
halcinonide	low	1	0
tretinoin	low	2	0
retinol	low	2	0
tacrolimus	low	13	0
thapsigargin	low	1	0
clindamycin	low	2	0
alitretinoin	low	1	0
potassium permanganate	low	1	0
bromochloroacetic acid	low	4	0
retinol acetate	low	1	0
terbinafine	low	1	0
fusidic acid	low	1	0
sodium dodecyl sulfate	low	1	0
calcitriol	low	4	0
etretinate	low	2	0
acitretin	low	5	0
topiramate	low	1	0
clobetasol	medium	1	1
goserelin	low	1	0
naltrexone	low	14	0
involucrin	low	2	0
apremilast	low	6	0
interleukin-8	low	2	0
calcipotriene	low	2	0
chlortetracycline	low	1	0
oxytetracycline, anhydrous	low	1	0
minocycline	low	4	0
salicylates	low	1	0
1 alpha,24-dihydroxyvitamin d3	low	3	0
cyclosporine	low	4	0

Protein Targets (773)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Luciferase	8	0	0	8
USP1 protein, partial	14	0	0	14
TDP1 protein	28	0	0	28
Microtubule-associated protein tau	11	0	0	11
AR protein	30	0	0	30
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
glucocorticoid receptor [Homo sapiens]	26	0	0	26
estrogen nuclear receptor alpha	37	0	0	37
peroxisome proliferator activated receptor gamma	19	0	0	19
euchromatic histone-lysine N-methyltransferase 2	21	0	0	21
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
vitamin D3 receptor isoform VDRA	13	0	0	13
thyroid hormone receptor beta isoform 2	18	0	0	18
flap endonuclease 1	8	0	0	8
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
geminin	29	0	0	29
peripheral myelin protein 22	13	0	0	13
survival motor neuron protein isoform d	10	0	0	10
histone acetyltransferase KAT2A isoform 1	9	0	0	9
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
Bile salt export pump	0	7	0	7
Bile salt export pump	0	25	0	25
Rap guanine nucleotide exchange factor 3	4	0	0	4
Cellular tumor antigen p53	22	0	0	22
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, Ferritin light chain	10	0	0	10
Chain A, Cruzipain	7	0	0	7
acetylcholinesterase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	19	0	0	19
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
GLI family zinc finger 3	24	0	0	24
estrogen receptor 2 (ER beta)	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
progesterone receptor	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	20	0	0	20
estrogen-related nuclear receptor alpha	24	0	0	24
pregnane X nuclear receptor	23	0	0	23
peroxisome proliferator-activated receptor delta	13	0	0	13
thyroid stimulating hormone receptor	11	0	0	11
Histone H2A.x	7	0	0	7
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Renin	0	0	1	1
Cytochrome P450 1A2	0	2	1	4
Retinoic acid receptor alpha	0	4	4	12
Retinoic acid receptor beta	0	4	4	12
Retinoic acid receptor alpha	0	2	3	5
Retinoic acid receptor gamma	0	4	4	12
Retinoic acid receptor gamma	0	1	3	4
Glutamate receptor 2	9	0	0	9
Retinoic acid receptor RXR-alpha	0	4	5	11
Retinoic acid receptor beta	0	1	3	4
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	4	6
Retinoic acid receptor RXR-beta	0	4	4	8
Retinoic acid receptor RXR-beta	0	1	4	5
Retinoic acid receptor RXR-gamma	0	1	4	5
Type-1 angiotensin II receptor	0	0	1	1
Cellular retinoic acid-binding protein 1	0	2	0	3
Retinoic acid receptor RXR-gamma	0	4	4	8
Type-2 angiotensin II receptor	0	0	1	1
Nuclear receptor ROR-gamma	7	1	2	10
Oxysterols receptor LXR-beta	0	0	1	1
Cellular retinoic acid-binding protein 1	0	0	2	2
Retinoic acid receptor RXR-alpha	0	0	1	1
Oxysterols receptor LXR-alpha	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	4	0	0	4
ATAD5 protein, partial	8	0	0	8
regulator of G-protein signaling 4	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
EWS/FLI fusion protein	11	0	0	11
nonstructural protein 1	3	0	0	3
arylsulfatase A	8	0	0	8
D(1A) dopamine receptor	4	0	0	4
chromobox protein homolog 1	12	0	0	12
thyroid hormone receptor beta isoform a	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
lamin isoform A-delta10	13	0	0	13
Plasminogen	0	4	1	5
Proton-coupled amino acid transporter 1	0	2	0	2
Chain A, Beta-lactamase	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Cytochrome P450 3A4	0	7	1	10
Cytochrome P450 2D6	0	4	1	6
Cytochrome P450 2C9	0	6	1	8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Cytochrome P450 2C19	0	4	1	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Carboxylic ester hydrolase	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	12	0	0	12
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	2	0	0	2
GLS protein	7	0	0	7
thyroid stimulating hormone receptor	7	0	0	7
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	3	0	0	3
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Bloom syndrome protein isoform 1	6	0	0	6
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	4	0	6
Carbonic anhydrase 2	0	4	2	8
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	4
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	4
Glutamate receptor ionotropic, NMDA 2B	0	4	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	4
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	4
Glutamate receptor ionotropic, NMDA 3B	0	3	1	4
Carbonic anhydrase 4	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	3	1	4
interleukin 8	6	0	0	6
Fumarate hydratase	4	0	0	4
thioredoxin glutathione reductase	7	0	0	7
farnesoid X nuclear receptor	14	0	0	14
G	9	0	0	9
polyprotein	4	0	0	4
P53	1	0	0	1
IDH1	7	0	0	7
aryl hydrocarbon receptor	11	0	0	11
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
heat shock protein beta-1	8	0	0	8
cytochrome P450 3A4 isoform 1	10	0	0	10
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	10	0	0	10
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit delta	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-5	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-6	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-2	10	0	0	10
GABA theta subunit	10	0	0	10
Inositol hexakisphosphate kinase 1	9	0	0	9
Canalicular multispecific organic anion transporter 1	0	17	0	17
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	14	0	0	14
Gamma-aminobutyric acid receptor subunit epsilon	10	0	0	10
Protein-arginine deiminase type-4	0	7	0	7
cytochrome P450 2C9, partial	9	0	0	9
pregnane X receptor	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	2	21
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	3	0	0	3
mitogen-activated protein kinase 1	6	0	0	6
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	3	0	3
Vitamin D3 receptor	0	2	3	8
Vitamin D3 receptor	0	1	1	3
Kappa-type opioid receptor	0	2	1	4
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier family 22 member 2	0	2	0	2
Transmembrane protease serine 2	0	2	1	3
Prothrombin	0	2	0	2
Serine protease hepsin	0	3	0	3
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Procathepsin L	0	2	1	3
Furin	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	2	1	3
Liver carboxylesterase 1	0	0	0	1
Trypsin-3	0	1	0	1
Spike glycoprotein	7	0	1	8
Hepatocyte growth factor activator	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Transmembrane protease serine 6	0	2	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
Angiotensin-converting enzyme 2	0	1	1	2
P2Y purinoceptor 12	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
DNA polymerase kappa isoform 1	7	0	0	7
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	4	0	4
Glycine receptor subunit alpha-1	0	0	3	3
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Smad3	4	0	0	4
PINK1	1	0	0	1
cytochrome P450 2D6	10	0	0	10
67.9K protein	5	0	0	5
Parkin	3	0	0	3
huntingtin isoform 2	2	0	0	2
Extracellular calcium-sensing receptor	0	0	1	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
streptokinase A precursor	0	0	3	3
ATP-dependent translocase ABCB1	0	3	1	4
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Solute carrier organic anion transporter family member 1B1	0	4	0	4
endonuclease IV	2	0	0	2
dopamine D1 receptor	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	3	0	0	3
Deoxycytidine kinase	0	0	0	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Histamine H2 receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	1	4	5
ATP-dependent translocase ABCB1	0	2	0	2
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	0	3
50S ribosomal protein L36 2	0	1	1	2
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	1
Thrombopoietin	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	3	0	4
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
Estrogen receptor	0	0	1	1
Guanine nucleotide-binding protein G	1	0	0	1
Estrogen receptor beta	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	2	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
large T antigen	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Membrane primary amine oxidase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Coagulation factor X	0	1	0	1
Coagulation factor XII	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Muscarinic acetylcholine receptor M2	0	6	1	8
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	5	0	5
Muscarinic acetylcholine receptor M1	0	5	0	6
Muscarinic acetylcholine receptor M3	0	6	0	6
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Solute carrier family 22 member 1	0	2	0	2
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Androgen receptor	0	3	0	3
DNA polymerase beta	3	0	0	3
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	4	0	4
Adenosine receptor A2a	0	2	0	2
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	3	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	4	1	5
Mu-type opioid receptor	0	5	1	6
Kappa-type opioid receptor	0	3	1	4
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	2	1	3
Mu-type opioid receptor	0	2	2	6
Delta-type opioid receptor	0	2	2	6
Kappa-type opioid receptor	0	2	1	6
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Mu-type opioid receptor	0	3	1	5
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Sodium-dependent noradrenaline transporter	0	6	0	6
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
N	0	1	0	1
NPYLR7B	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	0	1	1
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	5	0	5
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
D(1A) dopamine receptor	2	0	0	2
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	2	0	3
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	2	0	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	2	0	3
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	1	4
Carbonic anhydrase 7	0	2	0	3
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	2	0	3
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	3
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
DNA polymerase III, partial	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	1	2
Thymidine phosphorylase	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Mitogen-activated protein kinase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Research

Studies (143)

Protein Targets (773)

Benign Chronic Pemphigus

Synonyms(5)

Research Excerpts

Research

Studies (143)

Drugs Studied (80)

Protein Targets (773)