metronidazole has been researched along with Arthropathy, Neurogenic in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Arthropathy, Neurogenic: Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of pefloxacin-induced arthropathy in a 15-year-old patient with brain abscess." | 7.69 | Pefloxacin-induced arthropathy in an adolescent with brain abscess. ( Chang, H; Chung, MH; Kim, JH, 1996) |
| "We present a case of pefloxacin-induced arthropathy in a 15-year-old patient with brain abscess." | 3.69 | Pefloxacin-induced arthropathy in an adolescent with brain abscess. ( Chang, H; Chung, MH; Kim, JH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, H | 1 |
| Chung, MH | 1 |
| Kim, JH | 2 |
1 other study available for metronidazole and Arthropathy, Neurogenic
| Article | Year |
|---|---|
Pefloxacin-induced arthropathy in an adolescent with brain abscess.
Topics: Adolescent; Anti-Infective Agents; Arthropathy, Neurogenic; Brain Abscess; Ceftriaxone; Cephalospori | 1996 |