metronidazole has been researched along with Brain Neoplasms in 25 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas." | 9.04 | Radiation and high-dose metronidazole in supratentorial glioblastomas. ( Band, P; Chapman, JD; Feldstein, ML; Fryer, C; Mielke, B; Urtasun, R, 1976) |
| "We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas." | 5.04 | Radiation and high-dose metronidazole in supratentorial glioblastomas. ( Band, P; Chapman, JD; Feldstein, ML; Fryer, C; Mielke, B; Urtasun, R, 1976) |
| "Metronidazole was given in a dose of 6 g/m2 4 hr before each of the first 3 doses of RT to the whole-brain." | 2.65 | Metronidazole in the treatment of metastatic brain tumors. Results of a controlled clinical trial. ( Aiken, R; Deck, MD; Kim, JH; Leavengood, JM; Posner, JB; Thaler, HT, 1984) |
| "Metronidazole therapy was associated with substantial nausea and vomiting but no neurotoxicity was observed." | 2.65 | Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study. ( Eyre, HJ; Frank, J; LoBuglio, AF; Mansfield, CM; McCracken, JD; Ohlsen, JD; Weatherall, TJ, 1984) |
| "The diagnosis of actinomycosis is problematic because it is an uncommon infection and microbiological identification is often difficult and delayed." | 1.33 | [Disseminated actinomycosis]. ( Biron, F; Depagne, C; Guerin, JC; Louerat, C; Nesme, P, 2005) |
| "Treatment with metronidazole successfully eliminated the protozoa and cured the pyothorax." | 1.30 | Trichomonas tenax empyema in an immunocompromised patient with advanced cancer. ( Arizono, N; Morimoto, T; Nakao, K; Shimatsu, A; Shiota, T, 1998) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| " Maximum mean plasma drug concentration of 1 mM was obtained at 4 hours after drug ingestion with a mean half-life of 13 hours." | 1.27 | Human pharmacokinetics and toxicity of high-dose metronidazole administered orally and intravenously. ( Partington, J; Rabin, HR; Urtasun, RC, 1983) |
| "Metronidazole was administered orally to 25 patients and its maximum concentration in blood and tumor tissues, its ability to cross the blood/brain barrier and concentrate in the cerebrospinal fluid and brain tumor tissue, its immediate and long-term toxicity, and its enhancement of irradiation in normal tissue were studied." | 1.25 | Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells. ( Band, P; Chapman, JD; Fryer, CG; Rabin, HR; Sturmwind, J; Urtasun, RC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (72.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ouriemchi, W | 1 |
| Jeddi, D | 1 |
| Ziane, Y | 1 |
| El Quessar, A | 1 |
| Benouda, A | 1 |
| Guy, SD | 1 |
| Worth, LJ | 1 |
| Thursky, KA | 1 |
| Francis, PA | 1 |
| Slavin, MA | 1 |
| Louerat, C | 1 |
| Depagne, C | 1 |
| Nesme, P | 1 |
| Biron, F | 1 |
| Guerin, JC | 1 |
| Khan, SH | 1 |
| Sanche, SE | 1 |
| Robinson, CA | 1 |
| Pirouzmand, F | 1 |
| Gutin, PH | 2 |
| Wara, WM | 1 |
| Phillips, TL | 1 |
| Wilson, CB | 1 |
| Goldobenko, GV | 1 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| Aiken, R | 1 |
| Leavengood, JM | 1 |
| Kim, JH | 1 |
| Deck, MD | 1 |
| Thaler, HT | 1 |
| Posner, JB | 1 |
| Kiseleva, ES | 1 |
| Dar'ialova, SL | 1 |
| Eyre, HJ | 1 |
| Ohlsen, JD | 1 |
| Frank, J | 1 |
| LoBuglio, AF | 1 |
| McCracken, JD | 1 |
| Weatherall, TJ | 1 |
| Mansfield, CM | 1 |
| Stewart, DJ | 2 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Urtasun, RC | 4 |
| Rabin, HR | 2 |
| Partington, J | 1 |
| Potapov, SL | 1 |
| Karakulov, RK | 1 |
| Kachkov, IA | 2 |
| Pelevina, II | 2 |
| Liass, FM | 1 |
| Konradov, SA | 1 |
| Allen, N | 1 |
| Redondo, A | 1 |
| Tessier, C | 1 |
| Branger, C | 1 |
| Rey, A | 1 |
| Dahrouge, S | 1 |
| Agboola, O | 1 |
| Girard, A | 1 |
| Shiota, T | 1 |
| Arizono, N | 1 |
| Morimoto, T | 1 |
| Shimatsu, A | 1 |
| Nakao, K | 1 |
| Urtasun, R | 1 |
| Band, P | 2 |
| Chapman, JD | 3 |
| Feldstein, ML | 2 |
| Mielke, B | 1 |
| Fryer, C | 1 |
| Belli, JA | 1 |
| Hellman, S | 1 |
| Band, PR | 1 |
| Fowler, JF | 1 |
| Brückner, V | 1 |
| Fryer, CG | 1 |
| Sturmwind, J | 1 |
| Vartanian, LP | 1 |
| Rudenko, IIa | 1 |
| Volchkov, VA | 1 |
| Nelson, DF | 1 |
| Saunders, WM | 1 |
| Sheline, GE | 1 |
4 reviews available for metronidazole and Brain Neoplasms
| Article | Year |
|---|---|
Legionella pneumophila lung abscess associated with immune suppression.
Topics: Adult; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Australia; Azithromyci | 2011 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H | 1984 |
Recent and current investigations of radiation therapy of malignant gliomas.
Topics: Brachytherapy; Brain; Brain Neoplasms; Bromodeoxyuridine; Carmustine; Glioma; Helium; Humans; Hyperb | 1986 |
5 trials available for metronidazole and Brain Neoplasms
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
Metronidazole in the treatment of metastatic brain tumors. Results of a controlled clinical trial.
Topics: Anticonvulsants; Brain Neoplasms; Clinical Trials as Topic; Dexamethasone; Humans; Metronidazole; To | 1984 |
Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study.
Topics: Age Factors; Brain Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; | 1984 |
Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; beta Carotene; Brain Neoplasms; Cisplat | 1997 |
Radiation and high-dose metronidazole in supratentorial glioblastomas.
Topics: Administration, Oral; Adult; Aged; Brain Neoplasms; Cobalt Radioisotopes; Evaluation Studies as Topi | 1976 |
17 other studies available for metronidazole and Brain Neoplasms
| Article | Year |
|---|---|
[Arcanobacterium haemolyticum brain abscess mimicking a brain tumor].
Topics: Actinomycetales Infections; Amoxicillin; Anti-Bacterial Agents; Arcanobacterium; Biopsy; Brain Absce | 2011 |
[Disseminated actinomycosis].
Topics: Actinomyces; Actinomycosis; Alcoholism; Amoxicillin; Brain Abscess; Brain Neoplasms; Bronchoalveolar | 2005 |
N. paucivorans infection presenting as a brain abscess.
Topics: Anti-Bacterial Agents; Brain Abscess; Brain Neoplasms; Diagnosis, Differential; Humans; Hypertension | 2006 |
Hypoxic cell radiosensitizers in the treatment of malignant brain tumors.
Topics: Animals; Brain Neoplasms; Cricetinae; DNA; Glioblastoma; Humans; Hypoxia; In Vitro Techniques; Metro | 1980 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Human pharmacokinetics and toxicity of high-dose metronidazole administered orally and intravenously.
Topics: Administration, Oral; Animals; Brain Neoplasms; Cricetinae; Humans; Infusions, Parenteral; Kinetics; | 1983 |
[Sensitivity of human brain tumors to radiation and to the combined effect of metronidazole and radiation].
Topics: Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangioma; Humans; In Vitro Techniques; | 1982 |
[Metronidazole in the large split-dose concentrated irradiation of malignant gliomas].
Topics: Adult; Brain Neoplasms; Drug Evaluation; Glioma; Humans; Metronidazole; Radiation Tolerance; Radioth | 1980 |
Experimental therapy of brain tumors.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Methods; Metronidazole; Misonidazole; Neoplasms, Ex | 1980 |
[Comparative pharmacokinetics of antibiotics in blood, csf and brain].
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Blood; Brain; Brain Neoplasms; Cefamandole; Cerebro | 1993 |
Trichomonas tenax empyema in an immunocompromised patient with advanced cancer.
Topics: Acromegaly; Adenocarcinoma; Animals; Antitrichomonal Agents; Bone Marrow Neoplasms; Brain Neoplasms; | 1998 |
Editorial: Hypoxic cell radiosensitizers.
Topics: Brain Neoplasms; Glioblastoma; Male; Metronidazole; Oxygen; Radiation-Sensitizing Agents | 1976 |
Radiation plus metronidazole for glioblastoma.
Topics: Brain Neoplasms; Glioblastoma; Humans; Metronidazole; Radiation-Sensitizing Agents | 1977 |
Developments in radiotherapy other than heavy particle beams.
Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Hum | 1977 |
Photosensitizers and radiosensitizers in dermatology and oncology.
Topics: Brain Neoplasms; DNA; Humans; Methoxsalen; Metronidazole; Misonidazole; Mycosis Fungoides; Photochem | 1979 |
Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.
Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Mediasti | 1975 |
[The radiation therapy of experimental brain tumors by using the radiosensitizing preparation xanthobin (8-bromocaffeine)].
Topics: Animals; Brain Neoplasms; Caffeine; Drug Evaluation, Preclinical; Glioma; Metronidazole; Neoplasm Tr | 1989 |