Page last updated: 2024-12-06

1,3-dinitropyrene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1,3-Dinitropyrene: A Powerful Carcinogen in the Spotlight

**1,3-dinitropyrene (1,3-DNP)** is a potent polycyclic aromatic hydrocarbon (PAH) derivative. It's a highly toxic and carcinogenic compound that has been identified as a significant environmental contaminant.

Here's why 1,3-DNP is important for research:

**1. Environmental Concerns:**

* **Ubiquitous presence:** 1,3-DNP is found in various environmental matrices, including air, soil, water, and even human tissues. It's formed during the incomplete combustion of organic matter, making it a byproduct of various industrial processes, vehicle exhaust, and even cooking.
* **Bioaccumulation:** 1,3-DNP can accumulate in the environment and organisms, leading to long-term health risks.

**2. Health Impacts:**

* **Strong carcinogen:** 1,3-DNP is classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC), indicating it's a confirmed human carcinogen. It can cause various types of cancer, including lung, skin, and bladder cancer.
* **Genotoxicity:** 1,3-DNP damages DNA, leading to mutations and potentially cancer. It's also known to induce oxidative stress and inflammation in cells.

**3. Research Focus:**

* **Understanding the mechanism of action:** Researchers are studying how 1,3-DNP interacts with cells and DNA to better understand its carcinogenic potential. This includes exploring the role of metabolic enzymes in its activation and detoxification.
* **Developing methods for detection and remediation:** Scientists are working on developing sensitive analytical methods to detect 1,3-DNP in various environmental matrices. They're also investigating potential methods for remediation and removal of this contaminant.
* **Exploring potential health interventions:** Researchers are studying the potential of antioxidants and other protective agents to mitigate the harmful effects of 1,3-DNP exposure.

**4. Importance for Public Health:**

* **Risk assessment and mitigation:** Research on 1,3-DNP helps in understanding the potential health risks associated with exposure to this contaminant. This information is crucial for developing public health policies and regulations to protect human health.
* **Improving environmental monitoring:** Research contributes to developing more effective environmental monitoring programs to assess and control 1,3-DNP contamination.

**Overall, 1,3-DNP is a significant environmental and health concern that requires continued research efforts. Understanding its properties, health impacts, and environmental fate is critical for developing strategies to minimize exposure and protect human health.**

Cross-References

ID SourceID
PubMed CID53230
CHEMBL ID354669
CHEBI ID82456
SCHEMBL ID3293306
MeSH IDM0113262

Synonyms (20)

Synonym
1,3-dinitropyrene
pyrene, 1,3-dinitro-
brn 5292115
ccris 3381
1,3-dinitropyrene, 99%
CHEMBL354669
1,3-dinitro-pyrene
chebi:82456 ,
C19408
75321-20-9
d09d9l0924 ,
unii-d09d9l0924
AKOS015913367
SCHEMBL3293306
dinitropyrene, 1,3-
1,3-dinitropyrene [iarc]
DTXSID5074975
pyrene, 1,3-dinitro-; 1,3-dinitropyrene
1,3-dinitropyrene 100 microg/ml in toluene
Q27155954
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyrenes
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID23442Partition coefficient (logP)1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Structure-activity relationship of mutagenic aromatic and heteroaromatic nitro compounds. Correlation with molecular orbital energies and hydrophobicity.
AID200690Mutagenic activity in an Ames test on Salmonella Typhimurium TA98; Activity is log of revertants/nmol1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Structure-activity relationship of mutagenic aromatic and heteroaromatic nitro compounds. Correlation with molecular orbital energies and hydrophobicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-199019 (45.24)18.7374
1990's17 (40.48)18.2507
2000's6 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 15.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index15.61 (24.57)
Research Supply Index3.76 (2.92)
Research Growth Index4.19 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (15.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other40 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]