metronidazole has been researched along with Orphan Diseases in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present two cases of Lemierre's syndrome with internal jugular vein thrombophlebitis and positive blood cultures for F." | 1.51 | Lemierre's syndrome: One rare disease-Two case studies. ( Alaev, O; Bryan, A; Gelfman, A; Gennaro, D; Le, C; Marshall, D; Wang, Z, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, K | 1 |
| Fujiya, M | 1 |
| Sakatani, A | 1 |
| Fujibayashi, S | 1 |
| Nomura, Y | 1 |
| Ueno, N | 1 |
| Kashima, S | 1 |
| Goto, T | 1 |
| Sasajima, J | 1 |
| Moriichi, K | 1 |
| Okumura, T | 1 |
| Le, C | 1 |
| Gennaro, D | 1 |
| Marshall, D | 1 |
| Alaev, O | 1 |
| Bryan, A | 1 |
| Gelfman, A | 1 |
| Wang, Z | 1 |
| Iio, K | 1 |
| Ariyama, Y | 1 |
| Tomita, H | 1 |
| Sakakibara, H | 1 |
| Hataya, H | 1 |
| Compaoré, C | 1 |
| Kemta Lekpa, F | 1 |
| Nebie, L | 1 |
| Niamba, P | 1 |
| Niakara, A | 1 |
| Hefny, AF | 1 |
| Torab, FC | 1 |
| Joshi, S | 1 |
| Sebastian, M | 1 |
| Abu-Zidan, FM | 1 |
| Crema, MD | 1 |
| Pradel, C | 1 |
| Marra, MD | 1 |
| Arrivé, L | 1 |
| Tubiana, JM | 1 |
1 review available for metronidazole and Orphan Diseases
| Article | Year |
|---|---|
Actinomycosis of the gallbladder: case report and review of the literature.
Topics: Actinomycosis; Anti-Bacterial Agents; Cholecystectomy, Laparoscopic; Cholecystitis, Acute; Diagnosis | 2005 |
5 other studies available for metronidazole and Orphan Diseases
| Article | Year |
|---|---|
Second-line therapy for Helicobacter pylori eradication causing antibiotic-associated hemorrhagic colitis.
Topics: Abdominal Pain; Aged; Amoxicillin; Biopsy; Colitis; Colon; Colonoscopy; Female; Gastrointestinal Hem | 2017 |
Lemierre's syndrome: One rare disease-Two case studies.
Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Female; Fusobacterium Infections; Fusobacterium necropho | 2019 |
Secondary haemophagocytic lymphohistiocytosis associated with metronidazole.
Topics: Abdominal Abscess; Appendectomy; Appendicitis; Child; Dexamethasone; Female; Follow-Up Studies; Huma | 2019 |
Pentatrichomonas hominis infection in rheumatoid arthritis treated with adalimumab.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Follow-Up Studies; Human | 2013 |
Intramedullary spinal cord abscess complicating thoracic spondylodiscitis caused by Bacteroides fragilis.
Topics: Abscess; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Bacteroides fragilis; Bacteroides Infec | 2007 |