metronidazole has been researched along with Drug Abuse, Intravenous in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was added to his treatment regime." | 1.35 | Septic arthritis in a native joint due to Anaerococcus prevotii. ( Bui, V; Jain, S; Spencer, C; Yee, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pérez-Jacoiste Asín, MA | 1 |
| Fernández-Ruiz, M | 1 |
| Serrano-Navarro, I | 1 |
| Prieto-Rodriguez, S | 1 |
| Aguado, JM | 1 |
| Abdlslam, K | 1 |
| Thumbikat, P | 1 |
| Gibson, RJ | 1 |
| Jain, S | 1 |
| Bui, V | 1 |
| Spencer, C | 1 |
| Yee, L | 1 |
| Dancer, SJ | 1 |
| McNAIR, D | 1 |
| Finn, P | 1 |
| Kolsto, AB | 1 |
1 review available for metronidazole and Drug Abuse, Intravenous
| Article | Year |
|---|---|
Polymicrobial endocarditis involving Veillonella parvula in an intravenous drug user: case report and literature review of Veillonella endocarditis.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Endocarditis, Bacterial; Gram-Negative Bacterial Infectio | 2013 |
3 other studies available for metronidazole and Drug Abuse, Intravenous
| Article | Year |
|---|---|
Anaerobic infection of the lumbar spine in an intravenous drug abuser.
Topics: Adult; Anaerobiosis; Anti-Bacterial Agents; Ciprofloxacin; Clindamycin; Epidural Abscess; Female; Hu | 2002 |
Septic arthritis in a native joint due to Anaerococcus prevotii.
Topics: Adult; Anti-Bacterial Agents; Arthritis, Infectious; Bacteria, Anaerobic; Bacterial Infections; Drug | 2008 |
Bacillus cereus cellulitis from contaminated heroin.
Topics: Adult; Anti-Bacterial Agents; Bacillus cereus; Cellulitis; Forearm; Genotype; Gentamicins; Heroin; H | 2002 |