metronidazole has been researched along with Child Malnutrition in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Child Malnutrition: Malnutrition occurring in children ages 2 to 12 years, which is due to insufficient intake of food, dietary nutrients, or a pathophysiologic condition which prevents the absorption and utilization of food. Growth and development are markedly affected.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The biologic half-life of elimination was significantly longer (p less than 0." | 1.28 | Pharmacokinetics of metronidazole in severely malnourished and nutritionally rehabilitated children. ( Cravioto, J; Lares-Asseff, I; Pérez-Ortíz, B; Santiago, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Standing, JF | 1 |
| Ongas, MO | 1 |
| Ogwang, C | 1 |
| Kagwanja, N | 1 |
| Murunga, S | 1 |
| Mwaringa, S | 1 |
| Ali, R | 1 |
| Mturi, N | 1 |
| Timbwa, M | 1 |
| Manyasi, C | 1 |
| Mwalekwa, L | 1 |
| Bandika, VL | 1 |
| Ogutu, B | 1 |
| Waichungo, J | 1 |
| Kipper, K | 1 |
| Berkley, JA | 1 |
| Diouf, S | 1 |
| Diagne, I | 1 |
| Moreira, C | 1 |
| Signate, SY | 1 |
| Faye, O | 1 |
| Ndiaye, O | 1 |
| Sylla, A | 1 |
| Diallo, I | 1 |
| Thiam, D | 1 |
| Diop, B | 1 |
| Thiam, I | 1 |
| Gaye, I | 1 |
| Sarr, M | 1 |
| Fall, M | 1 |
| Lares-Asseff, I | 1 |
| Cravioto, J | 1 |
| Santiago, P | 1 |
| Pérez-Ortíz, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition[NCT03174236] | Phase 3 | 2,000 participants (Anticipated) | Interventional | 2017-09-04 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Child Malnutrition
| Article | Year |
|---|---|
Dosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutrition.
Topics: Acute Disease; Age Factors; Anti-Infective Agents; Ceftriaxone; Child Nutrition Disorders; Child Nut | 2018 |
2 other studies available for metronidazole and Child Malnutrition
| Article | Year |
|---|---|
[Integrated treatment of iron deficiency, vitamin A deficiency and intestinal parasitic diseases: impact on Senegalese children's growth].
Topics: Anemia, Iron-Deficiency; Anti-Infective Agents; Antinematodal Agents; Child Nutrition Disorders; Chi | 2002 |
Pharmacokinetics of metronidazole in severely malnourished and nutritionally rehabilitated children.
Topics: Child Nutrition Disorders; Child, Preschool; Female; Humans; Infant; Infant Nutrition Disorders; Mal | 1992 |