metronidazole has been researched along with Latent Tuberculosis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Latent Tuberculosis: The dormant form of TUBERCULOSIS where the person shows no obvious symptoms and no sign of the causative agent (Mycobacterium tuberculosis) in the SPUTUM despite being positive for tuberculosis infection skin test.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole (MTZ), which has activity only against anaerobic, nonreplicating bacteria, was as effective as either of these treatments in preventing reactivation of latent infection." | 1.38 | Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. ( Barry, CE; Dartois, V; Flynn, JL; Goodwin, MB; Janssen, C; Johnston, PJ; Klein, E; Lin, PL; Via, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Filippini, P | 1 |
| Iona, E | 1 |
| Piccaro, G | 1 |
| Peyron, P | 1 |
| Neyrolles, O | 1 |
| Fattorini, L | 1 |
| Lin, PL | 1 |
| Dartois, V | 1 |
| Johnston, PJ | 1 |
| Janssen, C | 1 |
| Via, L | 1 |
| Goodwin, MB | 1 |
| Klein, E | 1 |
| Barry, CE | 1 |
| Flynn, JL | 1 |
| Zhang, Y | 1 |
3 other studies available for metronidazole and Latent Tuberculosis
| Article | Year |
|---|---|
Activity of drug combinations against dormant Mycobacterium tuberculosis.
Topics: 3T3 Cells; Adipocytes; Amikacin; Animals; Antitubercular Agents; Aza Compounds; Capreomycin; Colony | 2010 |
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques.
Topics: Animals; Antiprotozoal Agents; Antitubercular Agents; Disease Models, Animal; Dose-Response Relation | 2012 |
Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.
Topics: Animals; Latent Tuberculosis; Metronidazole; Mycobacterium tuberculosis; Tuberculosis, Pulmonary | 2012 |