metronidazole has been researched along with Infections, Klebsiella in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The characteristics and outcomes of patients infected with ESBL-ENT were examined in a pooled analysis of Phase 3 clinical trials of ceftolozane/tazobactam in patients with complicated urinary tract infections (ASPECT-cUTI) and complicated intra-abdominal infections (ASPECT-cIAI)." | 9.24 | Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials. ( Bliss, CA; Cloutier, D; Hershberger, E; Huntington, JA; Kaye, KS; Miller, B; Paterson, DL; Popejoy, MW; Steenbergen, JN; Umeh, O, 2017) |
| " This study demonstrated the efficacy of penicillin and clavulanic acid in the treatment of infections caused by Bacteroides fragilis alone or in combination with beta-lactamase-producing aerobic bacteria." | 5.27 | Antibiotic and clavulanic acid treatment of subcutaneous abscesses caused by Bacteroides fragilis alone or in combination with aerobic bacteria. ( Brook, I; Coolbaugh, JC; Walker, RI, 1983) |
| " The characteristics and outcomes of patients infected with ESBL-ENT were examined in a pooled analysis of Phase 3 clinical trials of ceftolozane/tazobactam in patients with complicated urinary tract infections (ASPECT-cUTI) and complicated intra-abdominal infections (ASPECT-cIAI)." | 5.24 | Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials. ( Bliss, CA; Cloutier, D; Hershberger, E; Huntington, JA; Kaye, KS; Miller, B; Paterson, DL; Popejoy, MW; Steenbergen, JN; Umeh, O, 2017) |
| " We describe a patient who developed hemorrhagic colitis shortly after starting a course of amoxicillin therapy for sinusitis prophylaxis." | 3.74 | Amoxicillin-associated hemorrhagic colitis in the presence of Klebsiella oxytoca. ( Ernst, ME; Philbrick, AM, 2007) |
| "The purpose of this study was to determine if a change in the vaginal flora was associated with an increased risk of preterm birth, and to determine if metronidazole therapy before 32 weeks increased the risk of preterm birth." | 3.73 | Is a change in the vaginal flora associated with an increased risk of preterm birth? ( Carey, JC; Klebanoff, MA, 2005) |
| " Adverse events were reported by 9% of patients in the isepamicin group (16/178) and 10% of patients in the amikacin group (9/89)." | 2.68 | The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections. ( Leal del Rosal, P, 1995) |
| "Bacteremia was infrequently detected, but isolated pathogens were multidrug resistant." | 1.56 | Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi. ( Charles, A; Kadyaudzu, C; Onofrey, L; Prin, M; Purcell, L, 2020) |
| " This study demonstrated the efficacy of penicillin and clavulanic acid in the treatment of infections caused by Bacteroides fragilis alone or in combination with beta-lactamase-producing aerobic bacteria." | 1.27 | Antibiotic and clavulanic acid treatment of subcutaneous abscesses caused by Bacteroides fragilis alone or in combination with aerobic bacteria. ( Brook, I; Coolbaugh, JC; Walker, RI, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Schattner, A | 1 |
| Uliel, L | 1 |
| Finn, T | 1 |
| Dubin, I | 1 |
| Prin, M | 1 |
| Onofrey, L | 1 |
| Purcell, L | 1 |
| Kadyaudzu, C | 1 |
| Charles, A | 1 |
| Chen, HL | 1 |
| Bair, MJ | 1 |
| Lin, IT | 1 |
| Wu, CH | 1 |
| Lee, YK | 1 |
| Kim, HA | 1 |
| Chung, DR | 1 |
| Yeom, JS | 1 |
| Ki, HK | 1 |
| Cheong, HS | 1 |
| Son, JS | 1 |
| Lee, JS | 1 |
| Moon, SY | 1 |
| Lee, SS | 1 |
| Lee, JA | 1 |
| Park, KH | 1 |
| Kang, SJ | 1 |
| Jung, SI | 1 |
| Kim, SW | 1 |
| Chang, HH | 1 |
| Ryu, SY | 1 |
| Kwon, KT | 1 |
| Moon, C | 1 |
| Wi, YM | 1 |
| Heo, ST | 1 |
| Joung, MK | 1 |
| Kang, CI | 1 |
| Peck, KR | 1 |
| Song, JH | 1 |
| Pollett, S | 1 |
| McMullan, B | 1 |
| Lam, VW | 1 |
| Qureshi, C | 1 |
| Kok, J | 1 |
| Mills, JP | 1 |
| Talati, NJ | 1 |
| Alby, K | 1 |
| Han, JH | 1 |
| Mandrawa, CL | 1 |
| Cronin, K | 1 |
| Buising, KL | 1 |
| Poy Lorenzo, YS | 1 |
| Waters, MJ | 1 |
| Jeremiah, CJ | 1 |
| Hazarika, M | 1 |
| Pai H, V | 1 |
| Khanna, V | 1 |
| Reddy, H | 1 |
| Tilak, K | 1 |
| Chawla, K | 1 |
| Popejoy, MW | 1 |
| Paterson, DL | 1 |
| Cloutier, D | 1 |
| Huntington, JA | 1 |
| Miller, B | 1 |
| Bliss, CA | 1 |
| Steenbergen, JN | 1 |
| Hershberger, E | 1 |
| Umeh, O | 1 |
| Kaye, KS | 1 |
| Goren, MG | 1 |
| Carmeli, Y | 1 |
| Schwaber, MJ | 1 |
| Chmelnitsky, I | 1 |
| Schechner, V | 1 |
| Navon-Venezia, S | 1 |
| Rao, DD | 1 |
| Desai, A | 1 |
| Kulkarni, RD | 1 |
| Gopalkrishnan, K | 1 |
| Rao, CB | 1 |
| Adeyemo, A | 1 |
| Adeosun, A | 1 |
| Adedapo, K | 1 |
| Lodha, A | 1 |
| Wales, PW | 1 |
| James, A | 1 |
| Smith, CR | 1 |
| Langer, JC | 1 |
| Carey, JC | 1 |
| Klebanoff, MA | 1 |
| Philbrick, AM | 1 |
| Ernst, ME | 1 |
| Brook, I | 2 |
| Coolbaugh, JC | 1 |
| Walker, RI | 2 |
| Leal del Rosal, P | 1 |
3 trials available for metronidazole and Infections, Klebsiella
| Article | Year |
|---|---|
Anti-anaerobic coverage is not necessary for Klebsiella pneumoniae liver abscess: a propensity score-matched cohort study.
Topics: Aged; Anti-Bacterial Agents; Cohort Studies; Female; Humans; Klebsiella Infections; Klebsiella pneum | 2015 |
Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urin | 2017 |
The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Cholecystitis; Drug Administration Schedule; Escherichia col | 1995 |
15 other studies available for metronidazole and Infections, Klebsiella
| Article | Year |
|---|---|
'Giant' pyogenic liver abscess and
Topics: Alcoholism; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ceftriaxone; Diabe | 2020 |
Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi.
Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Bacteremia; Burkholderia Infections; Candida glabra | 2020 |
Clinical manifestations and risk factors of amebic liver abscess in Southeast Taiwan compared with other regions of Taiwan.
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Alcoholics; Amebicides; Anti-Bacterial Agents; Diabe | 2013 |
A 68-year-old type 2 diabetic man of Korean ethnicity with fever, abdominal pain, and right eye visual disturbance.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Bacteremia; Diabetes Mellitus, Type 2; Endophthalmitis; | 2015 |
The Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Colonization and Infection among Long-Term Acute Care Hospital Residents.
Topics: Aged; Anti-Bacterial Agents; Carbapenems; Carrier State; Case-Control Studies; Drug Resistance, Bact | 2016 |
Carbapenemase-producing Klebsiella pneumoniae: a major clinical challenge.
Topics: Azabicyclo Compounds; Bacterial Proteins; beta-Lactamases; Carbapenems; Ceftazidime; Drug Resistance | 2016 |
Rare Case of Polymicrobial Keratitis With Balantidium coli.
Topics: Anti-Bacterial Agents; Antiprotozoal Agents; Balantidiasis; Balantidium; Coinfection; Contact Lenses | 2016 |
Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Colisti | 2010 |
Comparison of maxillofacial space infection in diabetic and nondiabetic patients.
Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Case-Control Studi | 2010 |
Unusual cause of thyroid abscess.
Topics: Abscess; Anti-Infective Agents; Ceftriaxone; Drainage; Female; Humans; Infant; Klebsiella Infections | 2010 |
Acute appendicitis with fulminant necrotizing fasciitis in a neonate.
Topics: Acute Disease; Appendectomy; Appendicitis; Clindamycin; Combined Modality Therapy; Debridement; Drug | 2003 |
Is a change in the vaginal flora associated with an increased risk of preterm birth?
Topics: Administration, Intravaginal; Adult; Case-Control Studies; Cohort Studies; Confidence Intervals; Esc | 2005 |
Amoxicillin-associated hemorrhagic colitis in the presence of Klebsiella oxytoca.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Enterocolitis, Pseudomembranous; Humans; | 2007 |
Antibiotic and clavulanic acid treatment of subcutaneous abscesses caused by Bacteroides fragilis alone or in combination with aerobic bacteria.
Topics: Abscess; Animals; Anti-Bacterial Agents; Bacteroides Infections; Clavulanic Acid; Clavulanic Acids; | 1983 |
The relationship between Fusobacterium species and other flora in mixed infection.
Topics: Abscess; Animals; Bacteroides Infections; Escherichia coli Infections; Fusobacterium; Fusobacterium | 1986 |