metronidazole has been researched along with Chronic Idiopathic Intestinal Pseudo-Obstruction in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 5.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| "We report large-volume secretory diarrhea and intestinal pseudo-obstruction in a man whom ultimately proved to have Crohn's disease that responded to sulfasalazine and steroids with resolution of all his symptoms." | 4.79 | Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. ( Carethers, JM; McDonnell, WM; Owyang, C; Scheiman, JM, 1996) |
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 1.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Azuma, N | 1 |
| Ohta, M | 1 |
| Kageyama, Y | 1 |
| Kawanaka, Y | 1 |
| Matsui, K | 1 |
| Fujita, M | 1 |
| Nakano, Y | 1 |
| Yagita, M | 1 |
| Itou, H | 1 |
| Iizuka, M | 1 |
| Shindo, K | 1 |
| Konno, S | 1 |
| Watanabe, S | 1 |
| Keshavarzian, A | 1 |
| Isaacs, P | 1 |
| McColl, I | 1 |
| Sladen, GE | 1 |
| Carethers, JM | 1 |
| McDonnell, WM | 1 |
| Owyang, C | 1 |
| Scheiman, JM | 1 |
| Tak, PP | 1 |
| Van Duinen, CM | 1 |
| Bun, P | 1 |
| Eulderink, F | 1 |
| Kreuning, J | 1 |
| Gooszen, HG | 1 |
| Lamers, CB | 1 |
1 review available for metronidazole and Chronic Idiopathic Intestinal Pseudo-Obstruction
| Article | Year |
|---|---|
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease.
Topics: Anti-Inflammatory Agents; Crohn Disease; Diarrhea; Humans; Intestinal Pseudo-Obstruction; Male; Metr | 1996 |
5 other studies available for metronidazole and Chronic Idiopathic Intestinal Pseudo-Obstruction
| Article | Year |
|---|---|
Delayed onset of metronidazole-induced encephalopathy in a patient with systemic sclerosis accompanied by intestinal pseudo-obstruction.
Topics: Anti-Bacterial Agents; Brain; Brain Diseases; Diagnosis, Differential; Female; Humans; Intestinal Ps | 2020 |
Successful treatment of prokinetic-resistant intestinal pseudo-obstruction and pneumatosis cystoides intestinalis in systemic sclerosis with metronidazole.
Topics: Female; Gastrointestinal Agents; Humans; Intestinal Pseudo-Obstruction; Metronidazole; Middle Aged; | 2017 |
A case of pseudoobstruction of the intestine associated with scleroderma dramatically responding to antibiotics.
Topics: Aged; Anti-Infective Agents; Humans; Intestinal Pseudo-Obstruction; Male; Metronidazole; Scleroderma | 2006 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina | 1983 |
Pneumatosis cystoides intestinalis in intestinal pseudoobstruction. Resolution after therapy with metronidazole.
Topics: Aged; Humans; Intestinal Pseudo-Obstruction; Male; Metronidazole; Pneumatosis Cystoides Intestinalis | 1992 |