metronidazole has been researched along with Dental Plaque in 132 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dental Plaque: A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A single-blind clinical trial was carried out in 13 patients with adult periodontitis to compare the effects of subgingival application of metronidazole dental gel with those of subgingival scaling." | 10.18 | Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis. ( Awartani, FA; Zulqarnain, BJ, 1998) |
| "Despite the body of evidence supporting the clinical benefits of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of young patients with periodontitis, the microbiological outcomes of this antibiotic protocol have been less explored." | 9.69 | Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with Stages III and IV periodontitis: A secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial. ( Barão, VAR; de Figueiredo, LC; Duarte, PM; Faveri, M; Feres, M; Mestnik, MJ; Retamal-Valdes, B; Souza, JGS, 2023) |
| "The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX)." | 9.22 | Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Maciel, SS; Miranda, TS; Tamashiro, NS, 2016) |
| "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis." | 9.14 | Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. ( Cintan, S; Issever, H; Kantarci, A; Kulekci, G; Topcuoglu, N; Yek, EC, 2010) |
| "The aim of this study was to evaluate the clinical and microbiological effects of scaling and root planing (SRP) alone or combined with metronidazole (MTZ) and amoxicillin (AMX) in the treatment of subjects with generalized aggressive periodontitis (GAgP)." | 9.14 | Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Lira, EA; Mestnik, MJ, 2010) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 9.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The current investigation evaluated changes in levels and proportions of 39 bacterial species in subgingival plaque samples after scaling and root planing (SRP) alone or in combination with systemic metronidazole and/or professional cleaning in subjects with chronic periodontitis." | 9.11 | Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II--microbiological results. ( Carvalho, LH; D'Avila, GB; Feres, M; Gonçalves, C; Haffajee, AD; Leão, A; Socransky, SS, 2005) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 9.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "The Effect on the subgingival microflora of a single topical administration of a 95% collagen and 5% metronidazole device in combination with debridement was investigated in 30 adult periodontitis patients in comparison with mechanical treatment alone." | 9.08 | Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C, 1997) |
| "This study does not support the routine use of adjunctive metronidazole in the non-surgical treatment of periodontitis." | 9.08 | Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study. ( Matthews, JP; Palmer, RM; Wilson, RF, 1998) |
| "In this study, we evaluated the microbiological and clinical effects of mechanical debridement in combination with metronidazole and amoxicillin therapy in 48 patients with Actinobacillus actinomycetemcomitans-associated periodontitis, 3 months and at least 24 months after active treatment." | 9.07 | Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. ( de Graaff, J; Douqué, NH; Pavicić, MJ; Steures, RW; van Winkelhoff, AJ, 1994) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 9.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "Mechanical treatment associated with metronidazole and amoxicillin promoted a beneficial change in the microbiome of young individuals with severe periodontitis." | 8.02 | Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin. ( Bittinger, K; Faveri, M; Feres, M; Fermiano, D; Figueiredo, LC; Lee, JJ; Mayer, MPA; Retamal-Valdes, B; Teles, F, 2021) |
| "To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX)." | 7.88 | Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B; Soares, GMS; Yassine, LLS, 2018) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 7.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 7.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 7.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 7.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis." | 7.67 | Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. ( Addy, M; Wade, WG, 1987) |
| "The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene." | 7.67 | Systemic metronidazole in the treatment of periodontitis. ( Gilmour, WH; Jenkins, WM; MacFarlane, TW; MacKenzie, D; Ramsay, I, 1989) |
| "The present investigation was performed in order to assess if the administration of metronidazole changed the composition of developing plaque in dogs, which at the start of the study were free from signs of gingivitis." | 7.66 | The effect of metronidazole on the development of plaque and gingivitis in the beagle dog. ( Heijl, L; Lindhe, J, 1979) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 6.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| " A single-blind clinical trial was carried out in 13 patients with adult periodontitis to compare the effects of subgingival application of metronidazole dental gel with those of subgingival scaling." | 6.18 | Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis. ( Awartani, FA; Zulqarnain, BJ, 1998) |
| "Despite the body of evidence supporting the clinical benefits of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of young patients with periodontitis, the microbiological outcomes of this antibiotic protocol have been less explored." | 5.69 | Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with Stages III and IV periodontitis: A secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial. ( Barão, VAR; de Figueiredo, LC; Duarte, PM; Faveri, M; Feres, M; Mestnik, MJ; Retamal-Valdes, B; Souza, JGS, 2023) |
| "Metronidazole was administered orally to four squirrel monkeys (100 mg/kg/bwt) for 17 days." | 5.27 | Effect of metronidazole on development of subgingival plaque and experimental periodontitis. ( Eisenberg, AD; Espeland, MA; Polson, AM; Zappa, UE, 1986) |
| "The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX)." | 5.22 | Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Maciel, SS; Miranda, TS; Tamashiro, NS, 2016) |
| "A total of 184 patients with moderate-to-severe periodontitis were randomly allocated to one of four treatment groups: 1) FDIS+metronidazole; 2) FDIS+placebo; 3) SRP+metronidazole; or 4) SRP+placebo." | 5.17 | A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. ( Baelum, V; Gjermo, P; Gunleiksrud, TM; Preus, HR; Sandvik, L, 2013) |
| "The present investigation aimed to analyse clinical and microbiological effects of systemic administration of metronidazole and amoxicillin combined with the One-Stage-Full-Mouth-Disinfection protocol (OSFMD) in generalized aggressive periodontitis patients (G-AgP)." | 5.16 | Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. ( Aimetti, M; Carnevale, G; Guzzi, N; Romano, F, 2012) |
| "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis." | 5.14 | Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. ( Cintan, S; Issever, H; Kantarci, A; Kulekci, G; Topcuoglu, N; Yek, EC, 2010) |
| "The aim of this study was to evaluate the clinical and microbiological effects of scaling and root planing (SRP) alone or combined with metronidazole (MTZ) and amoxicillin (AMX) in the treatment of subjects with generalized aggressive periodontitis (GAgP)." | 5.14 | Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Lira, EA; Mestnik, MJ, 2010) |
| "To examine subgingival microbiological changes in chronic periodontitis subjects receiving scaling and root planing (SRP) alone or with systemically administered azithromycin, metronidazole or a sub-antimicrobial dose of doxycycline." | 5.13 | Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis. ( Haffajee, AD; Patel, M; Socransky, SS, 2008) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 5.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "Patients with previously untreated chronic periodontitis and subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to subgingival scaling without (control group) or with systemic amoxicillin plus metronidazole and CHX irrigation (test group)." | 5.11 | Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization. ( Beikler, T; Ehmke, B; Flemmig, TF; Milian, E; Moter, A, 2005) |
| "The present controlled, single-blind study was performed to assess and compare the clinical healing and the microbiological findings following repeated intrasulcular applications of 1% metronidazole or 1% chlorhexidine gels in persistent periodontal pockets previously treated by scaling and root planing (SRP)." | 5.11 | Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. ( Cordella, C; D'Ercole, S; Paolantonio, M; Perinetti, G; Piccolomini, R; Serra, E, 2004) |
| "The current investigation evaluated changes in levels and proportions of 39 bacterial species in subgingival plaque samples after scaling and root planing (SRP) alone or in combination with systemic metronidazole and/or professional cleaning in subjects with chronic periodontitis." | 5.11 | Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II--microbiological results. ( Carvalho, LH; D'Avila, GB; Feres, M; Gonçalves, C; Haffajee, AD; Leão, A; Socransky, SS, 2005) |
| "The purpose of the present investigation was to determine the percentage and identity of antibiotic-resistant species in subgingival plaque and saliva samples from chronic periodontitis patients treated by scaling and root planing followed by orally administered amoxicillin or metronidazole." | 5.10 | Antibiotic resistance of subgingival species during and after antibiotic therapy. ( Allard, K; Feres, M; Goodson, JM; Haffajee, AD; Socransky, SS; Som, S, 2002) |
| "Several studies have reported adjunctive benefits to scaling and root planing (SRP) of systemic amoxycillin and metronidazole in the treatment of periodontal diseases." | 5.10 | Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. ( Addy, M; Newcombe, RG; Rooney, J; Sprague, SV; Wade, WG, 2002) |
| "The effect of topical application of a metronidazole gel (ELYZOL DENTAL GEL), and adjunctive therapy in the treatment of adult periodontitis was assessed clinically." | 5.09 | Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy. ( Al-Mubarak, SA; Ho, A; Karring, T, 2000) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 5.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingivai irrigation with chlorhexidine digluconate (test)." | 5.08 | Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats. ( Flemmig, TF; Karch, H; Klaiber, B; Kopp, C; Milián, E, 1998) |
| "This study does not support the routine use of adjunctive metronidazole in the non-surgical treatment of periodontitis." | 5.08 | Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study. ( Matthews, JP; Palmer, RM; Wilson, RF, 1998) |
| "The Effect on the subgingival microflora of a single topical administration of a 95% collagen and 5% metronidazole device in combination with debridement was investigated in 30 adult periodontitis patients in comparison with mechanical treatment alone." | 5.08 | Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C, 1997) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 5.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "In this study, we evaluated the microbiological and clinical effects of mechanical debridement in combination with metronidazole and amoxicillin therapy in 48 patients with Actinobacillus actinomycetemcomitans-associated periodontitis, 3 months and at least 24 months after active treatment." | 5.07 | Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. ( de Graaff, J; Douqué, NH; Pavicić, MJ; Steures, RW; van Winkelhoff, AJ, 1994) |
| "The effect of metronidazole was assessed in 20 subjects with untreated periodontitis, in a double-blind trial." | 5.06 | Metronidazole: a double-blind trial in untreated human periodontal disease. ( Floyd, P; Palmer, R; Watts, T, 1986) |
| "Mechanical treatment associated with metronidazole and amoxicillin promoted a beneficial change in the microbiome of young individuals with severe periodontitis." | 4.02 | Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin. ( Bittinger, K; Faveri, M; Feres, M; Fermiano, D; Figueiredo, LC; Lee, JJ; Mayer, MPA; Retamal-Valdes, B; Teles, F, 2021) |
| "To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX)." | 3.88 | Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B; Soares, GMS; Yassine, LLS, 2018) |
| "Aggregatibacter (Actinobacillus) actinomycetemcomitans, Prevotella intermedia/nigrescens, Fusobacterium nucleatum and Eikenella corrodens from our strain collection and subgingival bacteria isolated from patients with periodontitis were tested for their susceptibility to amoxicillin and metronidazole using the Etest." | 3.80 | Combinatorial effects of amoxicillin and metronidazole on selected periodontal bacteria and whole plaque samples. ( Kulik Kunz, EM; Lenkeit, K; Walter, C; Waltimo, T; Weiger, R, 2014) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 3.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| " Systemic administration of combinations of metronidazole and either amoxicillin or ciprofloxacin has been widely used with great success; however the presence of subgingival yeasts and resistant bacteria can be a problem in some periodontitis patients." | 3.73 | Periodontal antimicrobials--finding the right solutions. ( Aalam, A; Jorgensen, MG; Slots, J, 2005) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 3.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 3.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 3.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene." | 3.67 | Systemic metronidazole in the treatment of periodontitis. ( Gilmour, WH; Jenkins, WM; MacFarlane, TW; MacKenzie, D; Ramsay, I, 1989) |
| "Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis." | 3.67 | Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. ( Addy, M; Wade, WG, 1987) |
| " Two double blind studies are reviewed which indicate that metronidazole plus mechanical debridement of the root surfaces is significantly better than placebo plus mechanical debridement in the treatment of advanced cases of periodontitis especially when the periodontal pockets are 6 mm or more in depth." | 3.67 | The therapeutic use of antimicrobial agents in patients with periodontal disease. ( Loesche, WJ, 1985) |
| "Metronidazole (10 microgram/ml) and cadmium sulfate (20 microgram/ml) were added to a gelatin-based medium to select for microaerophilic Actinomyces species from dental plaque samples." | 3.66 | New medium for isolation of Actinomyces viscosus and Actinomyces naeslundii from dental plaque. ( Kornman, KS; Loesche, WJ, 1978) |
| "The present investigation was performed in order to assess if the administration of metronidazole changed the composition of developing plaque in dogs, which at the start of the study were free from signs of gingivitis." | 3.66 | The effect of metronidazole on the development of plaque and gingivitis in the beagle dog. ( Heijl, L; Lindhe, J, 1979) |
| "In this study, periodontal disease progression was successfully arrested in 95% of the initially compromised lesions, while 2% to 5% experienced discrete or recurrent episodes of loss of periodontal support." | 2.70 | Aggressive periodontitis: 5-year follow-up of treatment. ( Buchmann, R; Lange, DE; Nunn, ME; Van Dyke, TE, 2002) |
| "Twenty adult patients with untreated periodontitis and subgingival colonization of A." | 2.69 | Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy. ( Beikler, T; Ehmke, B; Flemmig, TF; Karch, H; Klaiber, B; Kopp, C; Schmidt, H, 1999) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 2.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| "Periodontal diseases are common oral diseases that afflict all humans to some degree." | 2.37 | Current concepts in periodontal diseases. ( Higgins, TJ; Hunter, N; Knox, KW, 1985) |
| "Patients with chronic periodontitis (CP) may yield multiple species of putative periodontal bacterial pathogens that vary in their antibiotic drug susceptibility." | 1.40 | Antibiotic resistance in human chronic periodontitis microbiota. ( Degener, JE; Rams, TE; van Winkelhoff, AJ, 2014) |
| "Individuals with chronic periodontitis were classified as RP (n = 17) based on mean attachment loss (AL) and/or >3 sites with AL ≥2." | 1.38 | Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. ( Bennet, S; Colombo, AP; Cotton, SL; Dewhirst, FE; Goodson, JM; Haffajee, AD; Hasturk, H; Kent, R; Paster, BJ; Socransky, SS; Van Dyke, TE, 2012) |
| "Prepubertal periodontitis affects both primary and permanent dentition." | 1.30 | Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia. ( Kamma, JJ; Lygidakis, NA; Nakou, M, 1998) |
| "Metronidazole was significantly more effective than tetracycline or chlorhexidine on spirochaetes." | 1.27 | Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline. ( Addy, M; Langeroudi, M, 1984) |
| "Metronidazole was administered orally to four squirrel monkeys for 17 days at a daily dose of 100 mg/kg body weight." | 1.27 | Factors associated with occurrence and reversibility of connective tissue attachment loss. ( Polson, AM; Zappa, UE, 1988) |
| "Metronidazole was administered orally to four squirrel monkeys (100 mg/kg/bwt) for 17 days." | 1.27 | Effect of metronidazole on development of subgingival plaque and experimental periodontitis. ( Eisenberg, AD; Espeland, MA; Polson, AM; Zappa, UE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (25.00) | 18.7374 |
| 1990's | 34 (25.76) | 18.2507 |
| 2000's | 29 (21.97) | 29.6817 |
| 2010's | 31 (23.48) | 24.3611 |
| 2020's | 5 (3.79) | 2.80 |
| Authors | Studies |
|---|---|
| Faveri, M | 11 |
| Retamal-Valdes, B | 4 |
| Mestnik, MJ | 2 |
| de Figueiredo, LC | 1 |
| Barão, VAR | 1 |
| Souza, JGS | 1 |
| Duarte, PM | 6 |
| Feres, M | 15 |
| Zou, P | 3 |
| Wang, Y | 3 |
| Cao, P | 3 |
| Li, P | 3 |
| Liu, J | 3 |
| Luan, Q | 3 |
| Zago, LHP | 1 |
| de Annunzio, SR | 1 |
| de Oliveira, KT | 1 |
| Barbugli, PA | 1 |
| Valdes, BR | 1 |
| Fontana, CR | 1 |
| Feng, XH | 1 |
| Lu, RF | 1 |
| Zhang, L | 1 |
| Xu, L | 1 |
| Chen, ZB | 1 |
| Meng, HX | 1 |
| Fermiano, D | 1 |
| Figueiredo, LC | 10 |
| Mayer, MPA | 1 |
| Lee, JJ | 1 |
| Bittinger, K | 1 |
| Teles, F | 1 |
| Usin, MM | 1 |
| Tabares, SM | 1 |
| Menso, J | 1 |
| de Albera, ER | 1 |
| Sembaj, A | 1 |
| Burgess, DK | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial[NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation[NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| Mechanisms and Treatment Response of Aggressive Periodontitis in Children: Aberrant Immunological Phenotypes/Functions in the Progression of AgP[NCT01330719] | 514 participants (Actual) | Interventional | 2006-12-31 | Active, not recruiting | |||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study[NCT04830969] | Phase 2 | 116 participants (Actual) | Interventional | 2016-11-08 | Completed | ||
| Effects of a Toothpaste Containing 0.3% Triclosan in the Maintenance Phase of Peri-implantitis Treatment.[NCT03191721] | Phase 3 | 102 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial.[NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial[NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Full-mouth Periodontal Debridement Associated With Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial[NCT02969928] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Single Arm Pilot Study of Antimicrobial Treatment of Active Rheumatoid Arthritis Associated With Manifest Periodontitis (Translated From German: Anti-mikrobielle Behandlung Der Aktiven Rheumatoiden Arthritis Bei Manifester Parodontitis - Eine Unkontrollie[NCT02096120] | 8 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| Evaluation of Gingival Crevicular Fluid Interleukin-1β and Interleukin-17 Levels and Periodontal Pathogens After Full-Mouth Disinfection Initial Periodontal Treatment in Generalized Aggressive Periodontitis Patients[NCT02466646] | Phase 4 | 42 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| EFFECT OF LOCALLY DELIVERED ALOE VERA GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE TREATMENT OF CHRONIC PERIODONTITIS: A SPLIT-MOUTH CLINICAL AND MICROBIOLOGICAL STUDY[NCT02462993] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Full-mouth Periodontal Debridement With or Without Adjunctive Metronidazole Gel in Smoking Patients With Chronic Periodontitis[NCT01938183] | Phase 2 | 30 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Observational Study on Cytokine Production by Leukocytes of Papillon-Lefèvre Syndrome Patients and Healthy Probands in Whole Blood Cultures[NCT01116934] | 17 participants (Actual) | Observational | 2006-07-31 | Completed | |||
| Surgical Treatment of Peri-implantitis With and Without Adjunctive Use of Antibiotics : a Controlled and Randomized Clinical Study[NCT01857804] | Phase 4 | 100 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Analysis of microbiome community changes using the healthy plane (HP) as a reference. A healthy plane was calculated by fitting a plane that minimizes the sum of squares of distances from HC samples to the nearest point on the plane. The distance of each sample to the HP was then calculated. Higher values of distance to HP mean microbiome community changes towards disease status (NCT04830969)
Timeframe: Baseline to 6 Months
| Intervention | distance to the healthy plane (Mean) |
|---|---|
| Group A: SRP + SPT | -2.16 |
| Group B: SRP | -1.26 |
The high-sensitivity C-reactive protein (hs-CRP) blood test measures body inflammation indicating infection or a chronic inflammatory disease such as periodontitis or diabetes. It also can be used to evaluate risk of developing coronary artery disease. A normal reading is less than 10 milligram per liter (mg/L); a level greater than 10 mg/L is a sign of serious infection, trauma or chronic disease likely requiring further testing to determine cause (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/L (Mean) |
|---|---|
| Group A: SRP + SPT | -0.33 |
| Group B: SRP | -1.25 |
The high-sensitivity C-reactive protein (hs-CRP) blood test measures body inflammation indicating infection or a chronic inflammatory disease such as periodontitis or diabetes. It also can be used to evaluate risk of developing coronary artery disease. A normal reading is less than 10 milligram per liter (mg/L); a level greater than 10 mg/L is a sign of serious infection, trauma or chronic disease likely requiring further testing to determine cause (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/L (Mean) |
|---|---|
| Diabetic + SRP + SPT | 0.23 |
| Diabetic + SRP | -2.23 |
| Non-Diabetic + SRP + SPT | -0.41 |
| Non-Diabetic + SRP | 0.01 |
Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; site status is compared between timepoints measured (NCT04830969)
Timeframe: Baseline to 3 months
| Intervention | mm (Mean) |
|---|---|
| Group A: SRP + SPT | -0.31 |
| Group B: SRP | -0.21 |
Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; site status is compared between timepoints measured (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mm (Mean) |
|---|---|
| Group A: SRP + SPT | -0.25 |
| Group B: SRP | -0.18 |
Fasting blood sugar/glucose (FBS/FBG) is tested with a blood sample taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL is normal; a fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes; a level 126 mg/dL (7 mmol/L) or higher on two separate tests, indicates diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/dL (Mean) |
|---|---|
| Group A: SRP + SPT | -2.13 |
| Group B: SRP | 1.85 |
Fasting blood sugar/glucose (FBS/FBG) is tested with a blood sample taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL is normal; a fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes; a level 126 mg/dL (7 mmol/L) or higher on two separate tests, indicates diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/dL (Mean) |
|---|---|
| Diabetic + SRP + SPT | -5.05 |
| Diabetic + SRP | 2.74 |
| Non-Diabetic + SRP + SPT | 0.42 |
| Non-Diabetic + SRP | 0.72 |
Hemoglobin in A1c (HbA1c) tells the average level of blood sugar over the prior 2 to 3 months. Normal level is below 5.7%; 5.7%-6.4% indicates prediabetes; greater than 6.5% is indicative of diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | % of hemoglobin a1c (Mean) |
|---|---|
| Group A: SRP + SPT | -0.01 |
| Group B: SRP | 0.14 |
Hemoglobin in A1c (HbA1c) tells the average level of blood sugar over the prior 2 to 3 months. Normal level is below 5.7%; 5.7%-6.4% indicates prediabetes; greater than 6.5% is indicative of diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | % of hemoglobin a1c (Mean) |
|---|---|
| Diabetic + SRP + SPT | -0.04 |
| Diabetic + SRP | 0.30 |
| Non-Diabetic + SRP + SPT | 0.01 |
| Non-Diabetic + SRP | -0.07 |
The analysis is based on the measures of each participant. Participant instead of site is used as unite for arm/group. The measure, % sites with probing pocket depth >= 4 mm within each participant, indicates the portion of deep pocket in a participant. Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; The percentage of sites with Periodontal PD >= 4 mm within each participant was compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | % sites with PD >= 4 mm of a participant (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Group A: SRP + SPT | -8.71 | -7.03 |
| Group B: SRP | -4.74 | -4.73 |
The analysis is based on the measure of each participant. Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; The percentage of sites with Periodontal PD >= 4 mm per participant is compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | % sites with PD >= 4 mm of a participant (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Diabetic + SRP | -4.22 | 4.12 |
| Diabetic + SRP + SPT | -10.23 | -7.85 |
| Non-Diabetic + SRP | -5.4 | -5.52 |
| Non-Diabetic + SRP + SPT | -7.39 | -6.3 |
The analysis is based on the measures of each participant. Plaque is visually measured on 6 sites per tooth; 0 is the absence of any plaque. 1 is the presence of plaque. For each participant, 6 sites per tooth are evaluated. The Plaque Index (PI) of each participant is defined as the percentage of sites with plaque. The value of PI ranges from 0 to 100 for each participant. The PI of each participant is assessed and compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | Plaque Index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Group A: SRP + SPT | -14.76 | 9.68 |
| Group B: SRP | -7.7 | -5.19 |
The analysis is based on the measures of each participant. Plaque is visually measured on 6 sites per tooth; 0 is the absence of any plaque. 1 is the presence of plaque. For each participant, 6 sites per tooth are evaluated. The Plaque Index (PI) of each participant is defined as the percentage of sites with plaque. The value of PI ranges from 0 to 100 for each participant. The PI of each participant is assessed and compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | Plaque Index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -7.67 | -4.97 |
| Diabetic + SRP + SPT | -17.46 | -12.11 |
| Non-Diabetic + SRP | -7.75 | -5.48 |
| Non-Diabetic + SRP + SPT | -12.4 | -7.56 |
Probing depth (PD) or probing pocket depth (PPD), measured on six surfaces/tooth, is the distance in millimeters (mm) from the gingival margin to the base of the gingival pocket (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Diabetic + SRP | -0.17 | -0.12 |
| Diabetic + SRP + SPT | -0.36 | -0.27 |
| Non-Diabetic + SRP | -0.27 | -0.26 |
| Non-Diabetic + SRP + SPT | -0.26 | -0.24 |
The analysis is based on the measures of each participant. 0 is the absence of gingival bleeding and 1 is the presence of gingival bleeding after probing and measuring for pocket depth. Bleeding on probing index is defined as the percentage of sites with presence of gingival bleeding after probing per participant. The value of bleeding on probing index ranges from 0 to 100 for each participant. The bleeding on probing index per participant is compared between time points measured. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | BOP index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Group A: SRP + SPT | -13.24 | -8.93 |
| Group B: SRP | -5.57 | -4.09 |
The analysis is based on the measures of each participant. 0 is the absence of gingival bleeding and 1 is the presence of gingival bleeding after probing and measuring for pocket depth. Bleeding on probing index is defined as the percentage of sites with presence of gingival bleeding after probing per participant. The value of bleeding on probing index ranges from 0 to 100 for each participant. The bleeding on probing index per participant is compared between time points measured. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | BOP index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -4.35 | -1.95 |
| Diabetic + SRP + SPT | -13.45 | -9.62 |
| Non-Diabetic + SRP | -7.13 | -6.82 |
| Non-Diabetic + SRP + SPT | -13.06 | -8.32 |
The distance from the Cemento-enamel Junction (CEJ) to the free gingival margin is measured with a periodontal probe. Millimeters of recession (loss of attachment) is recorded as a negative number; when the gingival margin is above the CEJ, the measurement (in millimeters) is recorded as positive. (NCT04830969)
Timeframe: Baseline to 3 months;Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Group A: SRP + SPT | -0.1 | -0.1 |
| Group B: SRP | -0.2 | -0.12 |
The distance from the Cemento-enamel Junction (CEJ) to the free gingival margin is measured with a periodontal probe. Millimeters of recession (loss of attachment) is recorded as a negative number; when the gingival margin is above the CEJ, the measurement (in millimeters) is recorded as positive. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -0.17 | -0.06 |
| Diabetic + SRP + SPT | -0.11 | -0.14 |
| Non-Diabetic + SRP | -0.23 | -0.19 |
| Non-Diabetic + SRP + SPT | -0.1 | -0.07 |
Shannon index represents mean species diversity in a site at a local scale. Shannon index quantifies the uncertainty in predicting the species identity of an individual that is taken at random from the dataset. The minimum value is 0 and there is no maximum value. High values mean high species diversities. (NCT04830969)
Timeframe: Baseline; 6 Months
| Intervention | Shannon index value (Mean) | |
|---|---|---|
| Baseline | 6 Months | |
| Group A: SRP + SPT | 5.31 | 5.2 |
| Group B: SRP | 5.27 | 5.34 |
Attachment loss were recorded at baseline, 1st, 3rd and 6th months as millimeters. The data were compared among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 5.03 | 4.37 | 4.41 | 4.33 |
| Moxifloxacin | 4.94 | 4.14 | 3.98 | 4.30 |
We measured the probing depth at baseline, 1st, 3rd and 6th months. The changes were evaluated among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 4.57 | 3.12 | 3.11 | 3.15 |
| Moxifloxacin | 4.18 | 2.91 | 2.79 | 3.01 |
Patients will be instructed to fill a self-report form about any possible adverse effects in order to help evaluate their adherence to the systemic antimicrobial regimen. (NCT02969928)
Timeframe: One week post treatment
| Intervention | Participants (Count of Participants) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Headache | Stomach pain | Nausea/vomiting | Metallic taste | Diarrhea/abdominal pain | Drowsiness | Itching | Skin wounds | None | |
| Amoxicillin and Metronidazole | 1 | 4 | 3 | 7 | 3 | 2 | 1 | 0 | 5 |
| Clarithromycin | 2 | 3 | 6 | 13 | 3 | 3 | 0 | 0 | 5 |
Evaluate the difference between baseline and 6 months BoP measures. (NCT02969928)
Timeframe: Baseline, 3 and 6 months
| Intervention | % of sites with bleeding on probe (Mean) | ||
|---|---|---|---|
| Baseline | 3 months | 6 months | |
| Amoxicillin and Metronidazole | 53.4 | 30.2 | 27.3 |
| Clarithromycin | 43.7 | 24.8 | 23.3 |
Evaluate the difference between baseline and 6 months CAL measures. (NCT02969928)
Timeframe: Baseline, 3 and 6 months
| Intervention | mm (Mean) | ||
|---|---|---|---|
| Baseline | 3 months | 6 months | |
| Amoxicillin and Metronidazole | 3.69 | 2.4 | 3 |
| Clarithromycin | 3.62 | 3 | 3 |
Evaluate the difference between baseline and 6 months PB measures. (NCT02969928)
Timeframe: Baseline, 3 and 6 months
| Intervention | mm (Mean) | ||
|---|---|---|---|
| Baseline | 3 months | 6 months | |
| Amoxicillin and Metronidazole | 3.44 | 2.5 | 2.6 |
| Clarithromycin | 3.41 | 2.7 | 2.7 |
After 7 days of periodontal treatment, patients will be asked to return any medication not taken and/or the empty bottles. The number of pills not taken by the subject will be documented in order to evaluate compliance. (NCT02969928)
Timeframe: One week post treatment
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| # of patients that did not take ≥1 pills | # of patients that interrupted the drug intake | |
| Amoxicillin and Metronidazole | 3 | 2 |
| Clarithromycin | 4 | 0 |
Possible score for BOP range from %0 (no sites with bleeding on probing) to %100 (all sites with bleeding on probing). Higher scores mean worse outcome. (NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | percentage of BOP positive sites (Mean) | ||
|---|---|---|---|
| Baseline Bleeding on Probing (BOP) | 3rd month BOP | 6th month BOP | |
| Conventional IPT | 89.28 | 54.43 | 60.19 |
| Full-mouth Disinfection IPT | 78.30 | 38.87 | 42.78 |
| Full-mouth IPT | 85.77 | 48.90 | 49.74 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | mm (Mean) | ||
|---|---|---|---|
| Baseline Clinical Attachment Level (CAL) | 3rd month CAL | 6th month CAL | |
| Conventional IPT | 5.67 | 4.94 | 5.25 |
| Full-mouth Disinfection IPT | 5.20 | 4.54 | 4.51 |
| Full-mouth IPT | 5.79 | 5.10 | 5.13 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | Picogram (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline Interleukin-1β | 3rd month IL-1β | 6th month IL-1β | Baseline Interleukin-17 | 3rd month IL-17 | 6th month IL-17 | |
| Conventional IPT | 2.27 | 2.11 | 1.90 | 19.91 | 21.02 | 19.27 |
| Full-mouth Disinfection IPT | 2.53 | 2.07 | 2.11 | 18.53 | 21.07 | 20.05 |
| Full-mouth IPT | 2.15 | 2.06 | 1.96 | 19.67 | 19.76 | 18.46 |
Possible score for Gingival Index range from 0 (healthy gingiva) to 3 (severe gingivitis with bleeding). Higher scores mean worse outcome (NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline GI | 3rd month GI | 6th month GI | |
| Conventional IPT | 1.80 | 1.15 | 1.29 |
| Full-mouth Disinfection IPT | 1.61 | 1.17 | 1.20 |
| Full-mouth IPT | 1.74 | 1.24 | 1.21 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | log10(cells/ml) (Mean) | ||
|---|---|---|---|
| Baseline A. actinomycetemcomitans level | 3rd months A. actinomycetemcomitans level | 6th month A. actinomycetemcomitans level | |
| Conventional IPT | 3.84 | 3.73 | 3.59 |
| Full-mouth Disinfection IPT | 3.65 | 3.27 | 2.92 |
| Full-mouth IPT | 3.63 | 3.47 | 3.47 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | log10(cells/ml) (Mean) | ||
|---|---|---|---|
| Baseline C. rectus level | 3rd month C. rectus level | 6th month C. rectus level | |
| Conventional IPT | 6.19 | 5.01 | 4.99 |
| Full-mouth Disinfection IPT | 5.95 | 4.63 | 4.64 |
| Full-mouth IPT | 5.99 | 5.25 | 5.03 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | log10(cells/ml) (Mean) | ||
|---|---|---|---|
| Baseline F. nucleatum level | 3rd month F. nucleatum level | 6th month F. nucleatum level | |
| Conventional IPT | 4.78 | 3.99 | 3.84 |
| Full-mouth Disinfection IPT | 4.67 | 3.84 | 3.73 |
| Full-mouth IPT | 4.66 | 4.42 | 4.17 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | log10(cells/ml) (Mean) | ||
|---|---|---|---|
| Baseline P. micra level | 3rd month P. micra level | 6th month P. micra level | |
| Conventional IPT | 4.86 | 4.34 | 4.30 |
| Full-mouth Disinfection IPT | 4.96 | 4.22 | 4.28 |
| Full-mouth IPT | 4.70 | 4.51 | 4.43 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | log10(cells/ml) (Mean) | ||
|---|---|---|---|
| Baseline P. gingivalis level | 3rd months P. gingivalis level | 6th month P. gingivalis level | |
| Conventional IPT | 5.50 | 3.60 | 4.00 |
| Full-mouth Disinfection IPT | 4.64 | 2.90 | 3.25 |
| Full-mouth IPT | 5.47 | 3.74 | 3.84 |
(NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | log10(cells/ml) (Mean) | ||
|---|---|---|---|
| Baseline P. intermedia level | 3rd month P. intermedia level | 6th month P. intermedia level | |
| Conventional IPT | 5.51 | 3.70 | 4.14 |
| Full-mouth Disinfection IPT | 4.24 | 2.73 | 2.98 |
| Full-mouth IPT | 4.84 | 3.81 | 3.46 |
Possible scores for Plaque Index range from 0 (no plaque) to 3 (visible plaque all around the tooth). Higher scores mean a worse outcome (NCT02466646)
Timeframe: Baseline, 3 and 6 months after initial periodontal treatment
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline PI | 3rd month PI | 6th month PI | |
| Conventional IPT | 1.76 | 0.69 | 0.77 |
| Full-mouth Disinfection IPT | 1.51 | 0.67 | 0.72 |
| Full-mouth IPT | 1.62 | 0.84 | 0.82 |
(NCT02466646)
Timeframe: 6 months after initial periodontal treatment
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline Probing Depth (PD) | 6th month PD | |
| Conventional IPT | 4.80 | 3.40 |
| Full-mouth Disinfection IPT | 4.55 | 2.71 |
| Full-mouth IPT | 4.90 | 3.04 |
Concentrations of IL-8, IL-6, IP-10, interferon (IFN)-gamma, and IL-1 beta, in plasma/RPMI samples were determined by enzyme linked immunosorbent assay (ELISA) according to the manufacturers' instructions (NCT01116934)
Timeframe: 2006
| Intervention | pg/ml (Median) | ||||
|---|---|---|---|---|---|
| interleukin-1 beta | interleukin-6 | interferon-inducible protein-10 | interferon gamma | interleukin-8 | |
| Healthy Controls | 896.21 | 45734 | 11563 | 3317.4 | 44390 |
| Papillon-Lefèvre Syndrome (PLS) Patients | 1100.00 | 65559 | 12902.5 | 3704.5 | 50520 |
4 reviews available for metronidazole and Dental Plaque
| Article | Year |
|---|---|
[Metronidazole--an antibiotic for subgingival chemical plaque control?].
Topics: Animals; Clinical Trials as Topic; Dental Plaque; Drug Evaluation, Preclinical; Gingival Diseases; H | 1983 |
Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Antitrichomonal Agents; Dental Plaque; Dental Pl | 1998 |
Chemotherapy. A viable periodontal treatment modality?
Topics: Dental Plaque; Humans; Metronidazole; Periodontal Diseases; Tetracycline | 1990 |
Current concepts in periodontal diseases.
Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulc | 1985 |
57 trials available for metronidazole and Dental Plaque
| Article | Year |
|---|---|
Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with Stages III and IV periodontitis: A secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Dental Plaque; Dental Scaling; | 2023 |
Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2017 |
Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial.
Topics: Adult; Amoxicillin; Archaea; Biofilms; Chronic Periodontitis; Combined Modality Therapy; Dental Plaq | 2018 |
Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers.
Topics: Actinomyces; Adult; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cohort Studies; Combi | 2014 |
Reduction in prevalence of Archaea after periodontal therapy in subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Archaea; Combined Modality Ther | 2013 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Chronic Periodonti | 2014 |
Localized aggressive periodontitis treatment response in primary and permanent dentitions.
Topics: Adolescent; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Child; Child, Presc | 2014 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study.
Topics: Administration, Oral; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Ba | 2008 |
Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Bacteria; Combined Modality The | 2010 |
Systemic antimicrobials adjunctive to a repeated mechanical and antiseptic therapy for aggressive periodontitis: a 6-month randomized controlled trial.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Combined Modality Therapy; Dent | 2011 |
Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atherosclerosis; Biomarkers; Blood Glucose; Body Ma | 2012 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxic | 2012 |
A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Combined Modality T | 2013 |
Antibiotic resistance of subgingival species during and after antibiotic therapy.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Colony Count, Microbial; Dental Plaq | 2002 |
Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Dental Plaqu | 2000 |
Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients.
Topics: Adult; Anti-Infective Agents, Local; Case-Control Studies; Chlorhexidine; Chronic Disease; Colony Co | 2004 |
Intraoral dissemination of treponemes after periodontal therapy.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidi | 2004 |
Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II--microbiological results.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Bacteria, Anaerobic; Bacterial Typing Techniques | 2005 |
Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents | 2005 |
Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Case-Control Studi | 2006 |
Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis.
Topics: Adult; Anti-Infective Agents; Azithromycin; Chronic Disease; Dental Plaque; Dental Scaling; Doxycycl | 2008 |
[Metronidazole--an antibiotic for subgingival chemical plaque control?].
Topics: Animals; Clinical Trials as Topic; Dental Plaque; Drug Evaluation, Preclinical; Gingival Diseases; H | 1983 |
Effect of metronidazole on chronic periodontal disease in subjects using a topically applied chlorhexidine gel.
Topics: Administration, Topical; Adult; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Double-Blind | 1984 |
Possibilities for treating periodontal disease as specific anaerobic infections.
Topics: Adult; Animals; Bacteria, Anaerobic; Bacterial Infections; Clinical Trials as Topic; Dental Plaque; | 1984 |
Effect of combined systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease.
Topics: Adult; Aged; Bacteria; Combined Modality Therapy; Dental Plaque; Dental Prophylaxis; Female; Humans; | 1984 |
Development and evaluation of acrylic strips of metronidazole for the therapy of periodontal disease.
Topics: Administration, Topical; Cellulose; Chronic Disease; Dental Plaque; Dibutyl Phthalate; Humans; Methy | 1995 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Dental Plaque; Female; Gels; Gingival Hemorrhage | 1994 |
Metronidazole in periodontitis V: debridement should precede medication.
Topics: Adult; Analysis of Variance; Bacteria, Anaerobic; Clinical Protocols; Dental Plaque; Dental Scaling; | 1994 |
Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Bacteroides; Dental Plaque; Dental Plaque Index; | 1994 |
Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters.
Topics: Alveolar Bone Loss; Colony Count, Microbial; Dental Plaque; Dental Scaling; Double-Blind Method; Fem | 1993 |
Metronidazole in the treatment of localized juvenile periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Lo | 1993 |
Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Colony Count, Microbia | 1996 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aggregatibacter actinomycetemcomitans; A | 1997 |
Topical metronidazole application in recall patients. Long-term results.
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Bacteria; Dental Plaque; Dental Scaling | 1997 |
Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agen | 1998 |
Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Antitrichomonal Agents; Dental Plaque; Dental Pl | 1998 |
Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Analysis of Variance; Antitrichomonal Ag | 1998 |
Bacteriological and clinical follow-up of periodontal pockets during a topically applied 1% metronidazole-gel therapy in patients with adult periodontitis.
Topics: Administration, Topical; Adult; Dental Plaque; Female; Follow-Up Studies; Gels; Gingival Hemorrhage; | 1999 |
Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacterial Outer Me | 1999 |
Influence of oral Helicobacter pylori on the success of eradication therapy against gastric Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Anti-Bacterial Agents; Clarithromy | 2000 |
[Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis].
Topics: Administration, Oral; Adolescent; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Chemot | 2000 |
Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Dental Plaque; Double-Blind Method; Drug Com | 2001 |
Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Capsules; Chronic Disease; Colony C | 2002 |
Aggressive periodontitis: 5-year follow-up of treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Dental Plaque; Den | 2002 |
Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Delayed-Action Preparatio | 1992 |
The effects of metronidazole administration on clinical and microbiologic parameters of periodontal disease.
Topics: Analysis of Variance; Biological Assay; Chi-Square Distribution; Dental Plaque; Dental Plaque Index; | 1991 |
Effects of metronidazole on periodontal treatment needs.
Topics: Alveolar Bone Loss; Bacteria; Dental Plaque; Dental Scaling; Double-Blind Method; Female; Humans; Ma | 1991 |
The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease.
Topics: Analysis of Variance; Benzoylarginine-2-Naphthylamide; Dental Plaque; Double-Blind Method; Humans; M | 1990 |
The effect of 1% metronidazole gel in routine maintenance of persistent furcation involvement in human beings.
Topics: Adult; Aged; Bacteria; Combined Modality Therapy; Confidence Intervals; Delayed-Action Preparations; | 1989 |
The effects of a simplified mechanical oral hygiene regime plus supragingival irrigation with chlorhexidine or metronidazole on subgingival plaque.
Topics: Adult; Bacteria; Chlorhexidine; Dental Devices, Home Care; Dental Plaque; Equipment Design; Female; | 1986 |
Metronidazole: a double-blind trial in untreated human periodontal disease.
Topics: Adult; Bacteria; Cell Movement; Clinical Trials as Topic; Dental Plaque; Double-Blind Method; Female | 1986 |
A follow-up study 3 years after metronidazole therapy for chronic periodontal disease.
Topics: Chronic Disease; Dental Plaque; Dental Scaling; Follow-Up Studies; Gingival Hemorrhage; Humans; Metr | 1986 |
73 other studies available for metronidazole and Dental Plaque
| Article | Year |
|---|---|
Weak direct current exerts synergistic effect with antibiotics and reduces the antibiotic resistance: An in vitro subgingival plaque biofilm model.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biofilms; Dental | 2023 |
Weak direct current exerts synergistic effect with antibiotics and reduces the antibiotic resistance: An in vitro subgingival plaque biofilm model.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biofilms; Dental | 2023 |
Weak direct current exerts synergistic effect with antibiotics and reduces the antibiotic resistance: An in vitro subgingival plaque biofilm model.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biofilms; Dental | 2023 |
Weak direct current exerts synergistic effect with antibiotics and reduces the antibiotic resistance: An in vitro subgingival plaque biofilm model.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biofilms; Dental | 2023 |
Antimicrobial photodynamic therapy against metronidazole-resistant dental plaque bactéria.
Topics: Anti-Bacterial Agents; Biofilms; Chlorophyllides; Curcumin; Dental Plaque; Drug Resistance, Bacteria | 2020 |
[Effect of systemic use of amoxicillin and metronidazole during mechanical therapy on the periodontal microorganisms in subgingival plaque and saliva of patients with aggressive periodontitis].
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Dental Plaque; Dental Scaling; Humans; | 2020 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2016 |
Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study.
Topics: Amoxicillin; Anti-Bacterial Agents; Cohort Studies; Combined Modality Therapy; Dental Plaque; Dental | 2018 |
Assessment of viable periodontal pathogens by reverse transcription quantitative polymerase chain reaction.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Azides; Bacteria; Bacteri | 2013 |
Antibiotic resistance in human chronic periodontitis microbiota.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacterial Lo | 2014 |
Combinatorial effects of amoxicillin and metronidazole on selected periodontal bacteria and whole plaque samples.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Dental Plaque; Drug Resis | 2014 |
Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis.
Topics: Adolescent; Adult; Aged; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicilli | 2008 |
Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria; Bacteroides; Bacteroidetes; Campylobacter; Chro | 2009 |
Antibiotics in periodontics: right or wrong?
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroidaceae Infections; Combined Modality Therapy; Dental Pla | 2009 |
Antibiotic resistance of subgingival species in chronic periodontitis patients.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate C | 2010 |
The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count.
Topics: Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; CD4 Lymphocyte Count; Child; | 2010 |
Maintenance after a complex orthoperio treatment in a case of generalized aggressive periodontitis: 7-year result.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Amoxicillin-Pot | 2010 |
Additive or synergistic antimicrobial effects of amoxicillin and metronidazole on whole plaque samples: a preliminary report.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Biofilms; Colony Count, Microbial; D | 2011 |
Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray.
Topics: Amoxicillin; Anti-Infective Agents; Bacteria; Chi-Square Distribution; Chronic Periodontitis; Dental | 2012 |
Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and without periodontitis.
Topics: Animals; Anti-Bacterial Agents; Bacteroidaceae Infections; Clarithromycin; Dental Plaque; Dog Diseas | 2012 |
Therapeutic management of a case of generalised aggressive periodontitis in an 8-year old child: 18-month results.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; An | 2012 |
Antibiotic susceptibility of periodontal Enterococcus faecalis.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Anti- | 2013 |
Prevalence of β-lactamase-producing bacteria in human periodontitis.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bac | 2013 |
Antimicrobial activity of triantibiotic paste, 2% chlorhexidine gel, and calcium hydroxide on an intraoral-infected dentin biofilm model.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bacterial Load; Biofilms; Calcium Hydr | 2013 |
Change of antibiotic susceptibility following periodontal therapy. A pilot study in aggressive periodontal disease.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Potassium Clavulanate Combination; Anti-Ba | 2003 |
Selection for high-level resistance by chronic triclosan exposure is not universal.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Chlorhexidine; Dental Plaque; Drug Resistanc | 2004 |
Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerob | 2004 |
Periodontal antimicrobials--finding the right solutions.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Ciprofl | 2005 |
Drug-associated gingival enlargement: case report and review of aetiology, management and evidence-based outcomes of treatment.
Topics: Adult; Anti-Infective Agents; Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Decision Tree | 2005 |
Prevalence of subgingival bacteria resistant to aminopenicillins and metronidazole in dental patients from Yemen and Norway.
Topics: Adult; Bacteria, Anaerobic; Dental Plaque; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Fem | 2006 |
Periodontal therapy in siblings with Papillon-Lefèvre syndrome and tinea capitis: a report of two cases.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Ch | 2006 |
Antibiotic resistance in an in vitro subgingival biofilm model.
Topics: Adult; Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti | 2007 |
The bacteriology of acute necrotizing ulcerative gingivitis.
Topics: Bacteria; Bacteriological Techniques; Dental Plaque; Fusobacterium; Gingivitis, Necrotizing Ulcerati | 1982 |
Subgingival plaque control by a simplified oral hygiene regime plus local chlorhexidine or metronidazole.
Topics: Administration, Topical; Adult; Bacteria; Chlorhexidine; Delayed-Action Preparations; Dental Plaque; | 1983 |
[Plaque-inhibiting agents].
Topics: Anti-Bacterial Agents; Chlorhexidine; Dental Plaque; Humans; Hydrogen Peroxide; Metronidazole | 1983 |
[Susceptibility of potential periodontopathic bacteria to metronidazole, spiramycin and their combination].
Topics: Bacteria; Bacteroides; Dental Plaque; Drug Combinations; Erythromycin; Humans; Leucomycins; Metronid | 1984 |
Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline.
Topics: Acrylic Resins; Administration, Topical; Bacteria; Chlorhexidine; Dental Plaque; Humans; Metronidazo | 1984 |
Effect of selective antimicrobial therapy on plaque and gingivitis in the dog.
Topics: Animals; Bacteria; Clindamycin; Dental Plaque; Dogs; Drug Evaluation, Preclinical; Female; Gingiviti | 1980 |
Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole.
Topics: Adolescent; Adult; Bacteroides; Dental Plaque; Epithelial Attachment; Female; Humans; Male; Metronid | 1981 |
The effect of metronidazole on established gingivitis and plaque in beagle dogs.
Topics: Animals; Debridement; Dental Plaque; Dogs; Female; Gingivitis; Metronidazole; Time Factors; Toothbru | 1982 |
Development of plaque and gingivitis following antibiotic therapy in dogs.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Clindamycin; Dental Plaque; Dogs; Gingivitis; Metronidazol | 1982 |
[Effect of antimicrobial therapy on plaque and gingivitis in dogs].
Topics: Animals; Anti-Bacterial Agents; Clindamycin; Dental Plaque; Dogs; Gingivitis; Metronidazole; Vancomy | 1982 |
Experience with a novel selective medium for isolation of Actinomyces spp. from medical and dental specimens.
Topics: Actinomyces; Actinomycosis; Bacterial Typing Techniques; Bacteriological Techniques; Culture Media; | 1995 |
Antimicrobial susceptibility of periodontopathic bacteria associated with failing implants.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerob | 1995 |
Distribution of biotypes and antimicrobial susceptibility of Actinobacillus actinomycetemcomitans.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Antitrichomonal Age | 1995 |
Microbiological and immunohistological findings in a patient with Papillon-Lefèvre syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Child; Dental Care for Chronically Ill; Dental C | 1996 |
The effect of antimicrobial therapy on periimplantitis lesions. An experimental study in the dog.
Topics: Amoxicillin; Animals; Anti-Infective Agents; Dental Implants; Dental Plaque; Dogs; Equipment Contami | 1996 |
Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anaerobiosis; Anti-Bacterial Agents; Bacteroidaceae In | 1997 |
Periodontitis patient and the spouse: periodontal bacteria before and after treatment.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacteria; Campylobacter; Dental Calcul | 1997 |
Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin-Potassium Clavulanate C | 1998 |
Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs.
Topics: Alveolar Process; Animals; Anti-Infective Agents; Bone Regeneration; Chlorhexidine; Dental Implants; | 1999 |
Antibiotic susceptibility of putative periodontal pathogens in advanced periodontitis patients.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerobic; Bi | 1999 |
Resolution of peri-implantitis following treatment. An experimental study in the dog.
Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Amoxicillin; Animals; Anti-Bacter | 1999 |
Combined mechanical and antibiotic periodontal therapy in a case of Papillon-Lefèvre syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; | 2001 |
The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents | 2001 |
Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.
Topics: Actinomyces; Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Bacteroides; | 2001 |
Generalized cervical root resorption associated with periodontal disease.
Topics: Acids; Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial | 2001 |
The effect of systemic antimicrobial therapy on plaque and gingivitis in dogs.
Topics: Administration, Oral; Animals; Dental Plaque; Dogs; Gingivitis; Metronidazole; Tetracycline | 1979 |
Healthy and diseased gingiva.
Topics: Adult; Child; Chronic Disease; Dental Plaque; Diabetes Complications; Gingiva; Gingival Diseases; Gi | 1975 |
The effect of metronidazole on the development of plaque and gingivitis in the beagle dog.
Topics: Animals; Bacteria; Dental Plaque; Dogs; Gingiva; Gingivitis; Male; Metronidazole; Periodontal Index; | 1979 |
New medium for isolation of Actinomyces viscosus and Actinomyces naeslundii from dental plaque.
Topics: Actinomyces; Cadmium; Culture Media; Dental Plaque; Humans; Kanamycin; Metronidazole | 1978 |
The specific plaque hypothesis and the antimicrobial treatment of periodontal disease.
Topics: Bacteria, Anaerobic; Bacteroides; Benzoylarginine-2-Naphthylamide; Dental Plaque; Humans; Metronidaz | 1992 |
E-test: a new technique for antimicrobial susceptibility testing for periodontal microorganisms.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Ampicillin; Anti-Bacterial Agents; Bacteria; Bac | 1992 |
The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog.
Topics: Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Colony Count, Microbial; Delayed-Action Preparation | 1992 |
Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease.
Topics: Administration, Topical; Calorimetry, Differential Scanning; Dental Plaque; Gingiva; Humans; Metroni | 1989 |
[Subgingival administration of antimicrobials in periodontology. Update].
Topics: Chlorhexidine; Dental Plaque; Humans; Metronidazole; Periodontal Diseases; Tetracyclines; Therapeuti | 1989 |
Systemic metronidazole in the treatment of periodontitis.
Topics: Administration, Oral; Adult; Bacteria; Bacteroides; Dental Plaque; Dental Prophylaxis; Dental Scalin | 1989 |
The effect on the composition of subgingival plaque of a simplified oral hygiene system including pulsating jet subgingival irrigation.
Topics: Adult; Chlorhexidine; Dental Devices, Home Care; Dental Plaque; Double-Blind Method; Gingiva; Humans | 1986 |
Metronidazole therapy for periodontitis.
Topics: Dental Plaque; Dental Scaling; Double-Blind Method; Humans; Metronidazole; Patient Compliance; Perio | 1987 |
Factors associated with occurrence and reversibility of connective tissue attachment loss.
Topics: Animals; Bacterial Physiological Phenomena; Connective Tissue; Dental Plaque; Metronidazole; Periodo | 1988 |
Development of periodontal disease in a single flock of sheep: clinical signs, morphology of subgingival plaque and influence of antimicrobial agents.
Topics: Animals; Body Weight; Dental Plaque; Female; Gingiva; Metronidazole; Oxytetracycline; Periodontal Di | 1988 |
Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis.
Topics: Bacteria, Anaerobic; Dental Plaque; Humans; Metronidazole; Niridazole; Periodontal Pocket; Periodont | 1987 |
Effect of metronidazole on development of subgingival plaque and experimental periodontitis.
Topics: Animals; Bacteria; Connective Tissue; Dental Cementum; Dental Enamel; Dental Plaque; Gingiva; Metron | 1986 |
The therapeutic use of antimicrobial agents in patients with periodontal disease.
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Combined Modality Therapy; Debrid | 1985 |