Page last updated: 2024-09-28

Dens in Dente

Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.

Synonyms(1)

Synonym
Dens in Dente

Research

Studies (19)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (5.26)23.3326
1990's2 (10.53)12.5806
2000's5 (26.32)18.1394
2010's10 (52.63)28.8240
2020's1 (5.26)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ciprofloxacin0low10
haloperidol0low10
metronidazole0low10
edetic acid0low10
triamcinolone acetonide0low20
zinc oxide0low20
bisphenol a-glycidyl methacrylate0low10
gold0low10
calcium sulfate0low10
tricalcium silicate0low10
inositol 3-phosphate0low10
clindamycin0low30
bismuth0low10
phosphorus0low10
jaw0low10
sodium hypochlorite0low50
minocycline0low10
salicylates0low10
demeclocycline0low10
ledermix0low10

Protein Targets (325)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase2002
glp-1 receptor, partial2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma3003
SMAD family member 22002
ATAD5 protein, partial4004
SMAD family member 32002
TDP1 protein5005
GLI family zinc finger 33003
TSHR protein1001
AR protein4004
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha6006
67.9K protein1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH12002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid stimulating hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
DNA polymerase eta isoform 11001
geminin4004
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p534004
Glutamate receptor 23003
Alpha-synuclein1001
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Cruzipain1001
aldehyde dehydrogenase 1 family, member A12002
EWS/FLI fusion protein4004
cytochrome P450 2C9 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
lamin isoform A-delta103003
Gamma-aminobutyric acid receptor subunit pi1102
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0404
Cytochrome P450 1A20101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Cytochrome P450 3A40203
DNA gyrase subunit B0102
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
Cytochrome P450 2D60101
DNA topoisomerase 2-alpha0104
Cytochrome P450 2C9 0303
Gamma-aminobutyric acid receptor subunit beta-11102
Gamma-aminobutyric acid receptor subunit delta1102
Gamma-aminobutyric acid receptor subunit gamma-21102
Gamma-aminobutyric acid receptor subunit alpha-51102
Gamma-aminobutyric acid receptor subunit alpha-31102
DNA gyrase subunit A0102
Gamma-aminobutyric acid receptor subunit gamma-11102
Gamma-aminobutyric acid receptor subunit alpha-21102
Gamma-aminobutyric acid receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit gamma-31102
Gamma-aminobutyric acid receptor subunit alpha-61102
Cytochrome P450 2C190101
Multidrug resistance protein MdtK0011
Histamine H2 receptor3004
Gamma-aminobutyric acid receptor subunit alpha-11102
Gamma-aminobutyric acid receptor subunit beta-31102
Gamma-aminobutyric acid receptor subunit beta-21102
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Potassium voltage-gated channel subfamily H member 20405
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
GABA theta subunit1102
Canalicular multispecific organic anion transporter 10404
Gamma-aminobutyric acid receptor subunit epsilon1102
Protein-arginine deiminase type-40303
dopamine D1 receptor1001
thioredoxin reductase2002
GLS protein2002
regulator of G-protein signaling 42002
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 24004
hexokinase-4 isoform 11001
vitamin D3 receptor isoform VDRA2002
chromobox protein homolog 12002
glucokinase regulatory protein1001
flap endonuclease 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
ATP-dependent phosphofructokinase3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Histone H2A.x2002
nuclear factor erythroid 2-related factor 2 isoform 12002
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
acetylcholinesterase1001
15-lipoxygenase, partial1001
Fumarate hydratase1001
NFKB1 protein, partial1001
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease1001
thyroid stimulating hormone receptor2002
cytochrome P450 family 3 subfamily A polypeptide 42002
nonstructural protein 11001
cytochrome P450 2D62002
polyprotein1001
glucocerebrosidase1001
caspase-31001
Adenylate cyclase type 1 0101
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
D(1A) dopamine receptor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 221001
cytochrome P450 3A4 isoform 11001
transient receptor potential cation channel subfamily V member 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Cocaine esterase0101
Solute carrier family 22 member 1 0101
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20101
Albumin0011
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
ATP-dependent translocase ABCB10203
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0101
Integrin alpha-40101
D(2) dopamine receptor0215
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0202
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30101
D(1A) dopamine receptor0203
D(4) dopamine receptor0215
D(1B) dopamine receptor0203
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0101
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor0202
Adenosine receptor A10101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0101
C-8 sterol isomerase0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Kappa-type opioid receptor0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
Mu-type opioid receptor0213
Glutamate receptor ionotropic, NMDA 1 0101
D(3) dopamine receptor0215
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
D(1A) dopamine receptor1102
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20202
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein1001
D(2) dopamine receptor0202
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
TAR DNA-binding protein 433003
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0101
D0101
Sodium channel protein type 2 subunit alpha0101
Sigma non-opioid intracellular receptor 10202
Transient receptor potential cation channel subfamily V member 40101
Sodium channel protein type 3 subunit alpha0101
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0101
Chymotrypsinogen A0101
Thioredoxin reductase 0101
thyroid hormone receptor beta isoform a1001
mitogen-activated protein kinase 12002
muscleblind-like protein 1 isoform 11001
Flavodoxin0001
Lanosterol 14-alpha demethylase0101
Albumin0011
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Luciferase1001
Anthranilate phosphoribosyltransferase0101
Nuclear receptor ROR-gamma1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]