metronidazole has been researched along with Gastric Diseases in 29 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "14C-urea breath test was the "gold standard" and the specificity of the biopsy urease test in diagnosing H." | 2.39 | Bismuth therapy for Helicobacter pylori infection. A review of five years experience at a university hospital in Norway. ( Bergseth, M; Berstad, A; Berstad, K; Hundal, O; Olafsson, S; Tefera, S; Wilhelmsen, I, 1996) |
| "This case emphasizes the importance of adequately dosed antibiotic therapy, also for unusual bacteria such as species of Aeromonas." | 1.33 | [Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria]. ( Bomke, AK; Feyerherd, P; Podbielski, A, 2006) |
| "Metronidazole resistance was commoner in younger patients (P = 0." | 1.31 | Antibiotic resistance in Helicobacter pylori. ( Cullen, DJ; McGechie, DB; Mollison, LC; Stingemore, N; Wake, RA, 2000) |
| "metronidazole pretreatment." | 1.30 | The vascular and glandular organoprotective properties of metronidazole in the rodent stomach. ( Ching, CK; Cho, CH; Chow, JY; Ko, JK; Lam, SK; Zhang, ST, 1997) |
| "Metronidazole resistance was found in 6." | 1.30 | Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases. ( Chang, YS; Cheng, KS; Lin, CW; Wu, SC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 11 (37.93) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hwang, JJ | 1 |
| Lee, DH | 1 |
| Lee, AR | 1 |
| Yoon, H | 1 |
| Shin, CM | 1 |
| Park, YS | 1 |
| Kim, N | 1 |
| Liou, JM | 1 |
| Bair, MJ | 1 |
| Chen, CC | 2 |
| Lee, YC | 1 |
| Chen, MJ | 1 |
| Tseng, CH | 1 |
| Fang, YJ | 1 |
| Lee, JY | 1 |
| Yang, TH | 1 |
| Luo, JC | 1 |
| Wu, JY | 1 |
| Chang, WH | 1 |
| Chang, CC | 1 |
| Chen, CY | 1 |
| Chen, PY | 1 |
| Shun, CT | 1 |
| Hsu, WF | 1 |
| Hung, HW | 1 |
| Lin, JT | 1 |
| Chang, CY | 1 |
| Wu, MS | 1 |
| Hussain, A | 1 |
| Mahmood, H | 1 |
| Ansari, T | 1 |
| El-Hasani, S | 1 |
| Ellis, AE | 1 |
| Brown, CA | 1 |
| Miller, DL | 1 |
| Bani-Jaber, A | 1 |
| Al-Aani, L | 1 |
| Alkhatib, H | 1 |
| Al-Khalidi, B | 1 |
| Misselwitz, B | 1 |
| Kaiser, P | 1 |
| Bauerfeind, P | 1 |
| Vavricka, SR | 1 |
| Chuang, CH | 1 |
| Sheu, BS | 1 |
| Huang, AH | 1 |
| Yang, HB | 1 |
| Wu, JJ | 1 |
| Khurana, R | 1 |
| Fischbach, L | 1 |
| Chiba, N | 1 |
| Veldhuyzen van Zanten, S | 1 |
| Bomke, AK | 1 |
| Feyerherd, P | 1 |
| Podbielski, A | 1 |
| Foltz, CJ | 1 |
| Fox, JG | 1 |
| Yan, L | 1 |
| Shames, B | 1 |
| Banatvala, N | 1 |
| Davies, GR | 1 |
| Abdi, Y | 1 |
| Clements, L | 1 |
| Rampton, DS | 1 |
| Hardie, JM | 1 |
| Feldman, RA | 1 |
| Hosking, SW | 1 |
| Ling, TK | 1 |
| Chung, SC | 1 |
| Yung, MY | 1 |
| Cheng, AF | 1 |
| Sung, JJ | 1 |
| Li, AK | 1 |
| Berstad, A | 1 |
| Olafsson, S | 1 |
| Tefera, S | 1 |
| Berstad, K | 1 |
| Hundal, O | 1 |
| Bergseth, M | 1 |
| Wilhelmsen, I | 1 |
| Ko, JK | 1 |
| Ching, CK | 1 |
| Chow, JY | 1 |
| Zhang, ST | 1 |
| Lam, SK | 1 |
| Cho, CH | 1 |
| Hänninen, ML | 1 |
| Happonen, I | 2 |
| Jalava, K | 1 |
| Nawaz, A | 1 |
| Mohammed, I | 1 |
| Ahsan, K | 1 |
| Karakurum, A | 1 |
| Hadjiyane, C | 1 |
| Pellecchia, C | 1 |
| Lin, CW | 1 |
| Chang, YS | 1 |
| Wu, SC | 1 |
| Cheng, KS | 1 |
| Neiger, R | 1 |
| Seiler, G | 1 |
| Schmassmann, A | 1 |
| Linden, J | 1 |
| Westermarck, E | 1 |
| Mukhopadhyay, AK | 1 |
| Kersulyte, D | 1 |
| Jeong, JY | 1 |
| Datta, S | 1 |
| Ito, Y | 1 |
| Chowdhury, A | 1 |
| Chowdhury, S | 1 |
| Santra, A | 1 |
| Bhattacharya, SK | 1 |
| Azuma, T | 1 |
| Nair, GB | 1 |
| Berg, DE | 1 |
| Püspök, A | 1 |
| Kiener, HP | 1 |
| Susani, M | 1 |
| Müller, C | 1 |
| Mollison, LC | 1 |
| Stingemore, N | 1 |
| Wake, RA | 1 |
| Cullen, DJ | 1 |
| McGechie, DB | 1 |
| Chan, KL | 1 |
| Zhou, H | 1 |
| Ng, DK | 1 |
| Tam, PK | 1 |
| Maev, IV | 1 |
| V'iuchnova, ES | 1 |
| Lebedev, EG | 1 |
| Dicheva, DT | 1 |
| Ovsiannikova, EV | 1 |
| Antonenko, OM | 1 |
| Shchekina, MI | 1 |
| Vilaichone, RK | 1 |
| Mahachai, V | 1 |
| Katz, DE | 1 |
| Taylor, DN | 1 |
| Chittajallu, RS | 1 |
| Howie, CA | 1 |
| McColl, KE | 1 |
| Pesce, F | 1 |
| Barabino, A | 1 |
| Dufour, C | 1 |
| Caffarena, PE | 1 |
| Callea, F | 1 |
| Gatti, R | 1 |
| Jensen, LS | 1 |
| Andersen, F | 1 |
| Gjøde, P | 1 |
| Kiil, J | 1 |
| Kløve-Mogensen, M | 1 |
| Lauritzen, NP | 1 |
| Nielsen, L | 1 |
| Skovgaard, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Efficacy of Levofloxacin-based Sequential Therapy and Triple Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection- A Multi-center Randomized Trial[NCT01537055] | Phase 4 | 600 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metronidazole and Gastric Diseases
| Article | Year |
|---|---|
[New options for helicobacter pylori antibiotic treatment].
Topics: Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Dose-Response Relationship, Drug; Drug Administr | 2011 |
An update on anti-Helicobacter pylori treatment in children.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child; Clarithromycin; Helicobacter Infec | 2005 |
Bismuth therapy for Helicobacter pylori infection. A review of five years experience at a university hospital in Norway.
Topics: Antacids; Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Drug Therapy, Combination; Follow-Up St | 1996 |
[Experience in the use of losek (omeprazole) in gastroenterology].
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Clarithromycin; Double | 2001 |
Current management of Helicobacter pylori infection.
Topics: Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Helicobacter Infections; Heli | 2001 |
Parasitic infections of the gastrointestinal tract.
Topics: Adult; Animals; Anti-Infective Agents; Child; Child, Preschool; Entamoeba histolytica; Entamoebiasis | 2001 |
7 trials available for metronidazole and Gastric Diseases
| Article | Year |
|---|---|
Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease.
Topics: Aged; Anti-Bacterial Agents; Biopsy; Breath Tests; Clarithromycin; Drug Administration Schedule; Dru | 2015 |
Levofloxacin Sequential Therapy vs Levofloxacin Triple Therapy in the Second-Line Treatment of Helicobacter pylori: A Randomized Trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Drug Administration Schedule; Drug Monitoring; Drug | 2016 |
Vitamin C and E supplements to lansoprazole-amoxicillin-metronidazole triple therapy may reduce the eradication rate of metronidazole-susceptible Helicobacter pylori infection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Bacterial Agents; Ascorbic Acid; D | 2002 |
Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trial.
Topics: Adult; Aged; Antacids; Biopsy; Drug Resistance, Microbial; Drug Therapy, Combination; Duodenal Ulcer | 1994 |
Effect of triple therapy on eradication of canine gastric helicobacters and gastric disease.
Topics: Amoxicillin; Animals; Antacids; Anti-Bacterial Agents; Dog Diseases; Dogs; Drug Therapy, Combination | 2000 |
Effect of Helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer subjects.
Topics: Adult; Amoxicillin; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Gastric Acidity De | 1992 |
Peroperative cefuroxime v. long-term ampicillin and metronidazole in high-risk biliary and gastric surgery. A multicentre trial.
Topics: Adult; Aged; Ampicillin; Biliary Tract Diseases; Cefuroxime; Cephalosporins; Clinical Trials as Topi | 1987 |
16 other studies available for metronidazole and Gastric Diseases
| Article | Year |
|---|---|
Pneumomediastinum, stomach wall and hepatic portal vein gas secondary to partial necrosis of the stomach wall.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; A | 2009 |
Diagnostic exercise: chronic vomiting in a dog.
Topics: Animals; Antiprotozoal Agents; Biopsy; Cryptosporidiosis; Cryptosporidium; Diagnosis, Differential; | 2010 |
Prolonged intragastric drug delivery mediated by Eudragit® E-carrageenan polyelectrolyte matrix tablets.
Topics: Administration, Oral; Anti-Infective Agents; Carrageenan; Delayed-Action Preparations; Diffusion; Dr | 2011 |
[Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria].
Topics: Aeromonas; Anti-Bacterial Agents; Carcinoma, Signet Ring Cell; Cefotaxime; Gram-Negative Bacterial I | 2006 |
Evaluation of antibiotic therapies for eradication of Helicobacter hepaticus.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Base Sequence; Bismuth; Dose-Response Relationship, Dru | 1995 |
High prevalence of Helicobacter pylori metronidazole resistance in migrants to east London: relation with previous nitroimidazole exposure and gastroduodenal disease.
Topics: Adult; Developing Countries; Drug Resistance, Microbial; Duodenal Diseases; Female; Helicobacter Inf | 1994 |
The vascular and glandular organoprotective properties of metronidazole in the rodent stomach.
Topics: Animals; Capillary Permeability; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Membrane | 1997 |
Transmission of canine gastric Helicobacter salomonis infection from dam to offspring and between puppies.
Topics: Animals; Anti-Bacterial Agents; Biopsy; Disease Models, Animal; Dog Diseases; Dogs; Electrophoresis, | 1998 |
Clostridium difficile colitis associated with treatment of Helicobacter pylori infection.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Bismuth; Clostridioides difficile; Diarrhea; Enterocolitis | 1998 |
Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases.
Topics: ABO Blood-Group System; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antigens, Bacterial; | 1998 |
Use of a urea breath test to evaluate short-term treatments for cats naturally infected with Helicobacter heilmannii.
Topics: Animals; Antacids; Anti-Bacterial Agents; Anti-Ulcer Agents; Antitrichomonal Agents; Azithromycin; B | 1999 |
Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India.
Topics: Adult; Aged; Anti-Bacterial Agents; Antigens, Bacterial; Bacterial Proteins; Base Sequence; Drug Res | 2000 |
Gastric perforation of a left lobe amoebic liver abscess.
Topics: Adult; Animals; Anti-Infective Agents; Antifungal Agents; Biopsy, Needle; Follow-Up Studies; Gastros | 2000 |
Antibiotic resistance in Helicobacter pylori.
Topics: Anti-Bacterial Agents; Clarithromycin; Drug Resistance, Microbial; Female; Gastroscopy; Helicobacter | 2000 |
A prospective study of a one-week nonbismuth quadruple therapy for childhood Helicobacter pylori infection.
Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Child; Child, Preschool; C | 2001 |
Hypertrophic gastropathy with transient sessile polyps.
Topics: Animals; Child; Gastric Mucosa; Giardia lamblia; Giardiasis; Humans; Hypertrophy; Male; Metronidazol | 1992 |