metronidazole has been researched along with Endometriosis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mice were treated with broad-spectrum antibiotics or metronidazole, subjected to surgically-induced endometriosis and assayed after 21 days." | 7.91 | Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. ( Chadchan, SB; Cheng, M; Kommagani, R; Mysorekar, IU; Parnell, LA; Schriefer, A; Yin, Y, 2019) |
| "Mice were treated with broad-spectrum antibiotics or metronidazole, subjected to surgically-induced endometriosis and assayed after 21 days." | 3.91 | Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. ( Chadchan, SB; Cheng, M; Kommagani, R; Mysorekar, IU; Parnell, LA; Schriefer, A; Yin, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chadchan, SB | 1 |
| Cheng, M | 1 |
| Parnell, LA | 1 |
| Yin, Y | 1 |
| Schriefer, A | 1 |
| Mysorekar, IU | 1 |
| Kommagani, R | 1 |
| Kurt, M | 1 |
| Ibis, M | 1 |
| Karaman, K | 1 |
| Bostanci, EB | 1 |
| Temucin, T | 1 |
| LOCK, FR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery: A Prospective, Randomized, Placebo-Controlled Trial[NCT04554693] | Phase 4 | 90 participants (Anticipated) | Interventional | 2020-10-19 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for metronidazole and Endometriosis
| Article | Year |
|---|---|
Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Disease Progression; Endometriosis; Endometr | 2019 |
Rectal endometriosis and prolactinoma.
Topics: Adult; Anti-Infective Agents; Bromocriptine; Ciprofloxacin; Endometriosis; Female; Hormone Antagonis | 2010 |
GYNECOLOGY AND OBSTETRICS.
Topics: Congenital Abnormalities; Endometriosis; Female; Fetal Diseases; Gynecology; Humans; Maternal-Fetal | 1964 |