metronidazole and Infection, Puerperal studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

Excerpt	Relevance	Reference
"Thirteen patients with abscess of the abdominal wall, including one case of endomyometritis following caesarean section, received metronidazole treatment (Vagimid), on the first two days of therapeutic action."	3.66	[Use of metronidazole in treatment of postoperative obstetric infections (author's transl)]. ( Amon, I; Amon, K; Bernhardt, H; Zschiesche, M, 1981)
"To evaluate the role of anaerobic bacteria in postpartum endomyometritis, intravenous metronidazole was used as the sole initial therapy in 25 women with clinical signs of infection."	3.66	The role of anaerobic bacteria in postpartum endomyometritis. ( Ledger, WJ; Platt, LD; Yonekura, ML, 1979)
"Significant reductions in surgical site infections (relative risk, 0."	2.72	Preincision adjunctive prophylaxis for cesarean deliveries a systematic review and meta-analysis. ( Babatunde, I; Fan, C; Goje, O; Hackett, L; Joo, J; Markwei, MT; Prah, MA; Rathi, N; Soper, DE, 2021)
"Metronidazole was well tolerated by the mother and with this type of administration regimen, the fetus is not exposed to the drug."	2.67	Prevention of postcesarean infectious morbidity with a single dose of intravenous metronidazole. ( Garcia-Rojas, JM; Lozada-Leon, JD; Ruiz-Moreno, JA, 1991)
"Once the diagnosis of clinical chorioamnionitis has been established, delivery should be considered, regardless of the gestational age."	2.66	Management of clinical chorioamnionitis: an evidence-based approach. ( Conde-Agudelo, A; Garcia Sánchez, ÁJ; Jung, EJ; Romero, R, 2020)
"Metronidazole which has been widely used in the treatment of trichomoniasis urogenitalis is the most active agent available against obligate anaerobes."	1.27	[Metronidazole in the treatment and prevention of infections in gynecology and obstetrics]. ( Amon, I; Amon, K, 1983)
"Oral metronidazole was given as therapy in 25 women with the clinical diagnosis of a postpartum anaerobic soft tissue pelvic infection following a vaginal delivery."	1.26	A new approach to patients with suspected anaerobic postpartum pelvic infections. Transabdominal uterine aspiration for culture and metronidazole for treatment. ( Finegold, SM; Gee, CL; Ledger, WJ; Lewis, WP; Pollin, PA; Sutter, VL, 1976)

Research

Studies (36)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Infant Pyloric Stenosis

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (66.67)	18.7374
1990's	6 (16.67)	18.2507
2000's	3 (8.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	3 (8.33)	2.80

Authors	Studies
Lambert, KA	1
Honart, AW	1
Hughes, BL	1
Kuller, JA	1
Dotters-Katz, SK	1
Conde-Agudelo, A	1
Romero, R	1
Jung, EJ	1
Garcia Sánchez, ÁJ	1
Markwei, MT	1
Babatunde, I	1
Rathi, N	1
Fan, C	1
Prah, MA	1
Joo, J	1
Hackett, L	1
Soper, DE	1
Goje, O	1
Alekwe, LO	1
Kuti, O	1
Orji, EO	1
Ogunniyi, SO	1
Tita, ATN	1
Rouse, DJ	1
Blackwell, S	1
Saade, GR	1
Spong, CY	1
Andrews, WW	1
Kayihura, V	1
Osman, NB	1
Bugalho, A	1
Bergström, S	1
Gini, PC	1
Chukudebelu, WO	1
Sol'skiĭ, IaP	1
Ivchenko, VN	1
Gummerus, M	1
Atanasov, A	1
Katranushkova, N	1
Katsulov, A	1
Matheson, I	1
Emel'ianova, AI	2
Baltrashevich, AK	1
Kushnareva, MV	1
Komarovskaia, TP	1
Rukhadze, TG	1
Amon, K	2
Amon, I	2
Vacca, A	1
Henderson, A	1
Moodley, J	1
Zeeman, DJ	1
Zschiesche, M	1
Bernhardt, H	1
Bibi, M	1
Megdiche, H	1
Ghanem, H	1
Sfaxi, I	1
Nouira, M	1
Essaidi, H	1
Chaieb, A	1
Slama, A	1
Khairi, H	1
Cohen, RO	1
Colodner, R	1
Ziv, G	1
Keness, J	1
Gardó, S	1
Shah, S	1
Mazher, Y	1
John, IS	1
Leach, RD	1
Eykyn, SJ	1
Phillips, I	1
Corrin, B	1
Willis, AT	1
Platt, LD	1
Yonekura, ML	1
Ledger, WJ	2
Seligman, SA	1
Gee, CL	1
Pollin, PA	1
Lewis, WP	1
Sutter, VL	1
Finegold, SM	1
Ruiz-Moreno, JA	1
Garcia-Rojas, JM	1
Lozada-Leon, JD	1
Elmahaishi, MS	1
Kukelková, H	1
Sokolowski, H	1
Canzler, E	1
Brötzmann, C	1
Chan, AC	1
Leung, AK	1
Chin, RK	1
Chang, AM	1
McCahill, ME	1
Braff, DL	1
Gurtovoĭ, BL	1
Voropaeva, SD	1
Sokolova, IE	1
Gaudin, G	1
Wilkowske, CJ	1
Hermans, PE	1
Wawryk, R	1
Chruściel, A	1
Piotrowicz, B	1
Zawadzki, J	1
Starzyk, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Prevention of Maternal and Neonatal Death/Infections With a Single Oral Dose of Azithromycin in Women in Labor (in Low- and Middle-income Countries): a Randomized Controlled Trial[NCT03871491]	Phase 3	34,000 participants (Anticipated)	Interventional	2020-09-01	Active, not recruiting
Peri-operative Cefazolin Prophylaxis at Time of Cesarean Delivery in the Obese Gravida[NCT01904500]	Phase 1	26 participants (Anticipated)	Interventional	2013-08-31	Completed
Cesarean Section Optimal Antibiotic Prophylaxis Trial[NCT01235546]		2,013 participants (Actual)	Interventional	2011-05-31	Completed
Azithromycin-based Extended-spectrum Prophylaxis in Scheduled Cesarean Deliveries[NCT03960970]	Phase 2	800 participants (Anticipated)	Interventional	2019-09-15	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Any diagnosis of pyloric stenosis based on clinical presentation and radiological and/or surgical confirmation (NCT01235546)
Timeframe: up to 3 months after birth

Maternal Fever

Maternal Postpartum Antibiotic Use

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	1
Azithromycin and Standard of Care	2

Intervention	Participants (Count of Participants)
Placebo With Standard Prophylaxis	81
Azithromycin (Zithromax) With Standard Prophylaxis	51

Maternal postpartum use of antibiotics (NCT01235546)
Timeframe: Up to 6 weeks after delivery

Maternal Postpartum Readmission or Unscheduled Visit

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	166
Azithromycin and Standard of Care	126

Maternal postpartum unscheduled visit or readmission to the hospital (NCT01235546)
Timeframe: Up to 6 weeks after delivery

Maternal Serious Adverse Events

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	123
Azithromycin and Standard of Care	83

All maternal serious adverse events (NCT01235546)
Timeframe: Up to 6 weeks after delivery

Neonatal Intensive Care Unit (NICU) Admission

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	29
Azithromycin and Standard of Care	15

Neonates who are admitted to the NICU due to morbidities diagnosed from birth and up to three months of life. Morbidities as defined in the Neonatal morbidities outcome measure. (NCT01235546)
Timeframe: Up to 3 months after birth

Neonatal Morbidities (Listed Below)

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	169
Azithromycin and Standard of Care	171

morbidities include: death, Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD), Periventricular Leukomalacia (PVL) suspected or proven sepsis, Necrotizing Enterocolitis (NEC) Intraventricular Hemorrhage (IVH) and systemic inflammatory response syndrome (NCT01235546)
Timeframe: Up to 3 months after birth

Neonatal Readmission

Neonatal Serious Adverse Events

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	135
Azithromycin and Standard of Care	146

Intervention	Participants (Count of Participants)
Placebo With Standard Prophylaxis	43
Azithromycin (Zithromax) With Standard Prophylaxis	39

Composite for all neonatal serious adverse events (NCT01235546)
Timeframe: Up to 3 months after birth

Participants With Endometritis and/or Wound Infection and/or Other Post-cesarean Infections (Occurring Within 6 Weeks of Delivery)

Intervention	Participants (Count of Participants)
Placebo and Standard of Care	5
Azithromycin and Standard of Care	7

Endometritis was defined as the presence of at least two of the following signs with no other recognized cause: fever (temperature of at least 38°C [100.4°F]), abdominal pain, uterine tenderness, or purulent drainage from the uterus. Wound infection was defined as the presence of either superficial or deep incisional surgical-site infection characterized by cellulitis or erythema and induration around the incision or purulent discharge from the incision site with or without fever and included necrotizing fasciitis. Wound hematoma, seroma, or breakdown alone in the absence of the preceding signs did not constitute infection. (NCT01235546)
Timeframe: Up to 6 weeks after delivery

Article	Year
Management of clinical chorioamnionitis: an evidence-based approach. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6 Topics: Acetylcysteine; Adrenal Cortex Hormones; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents, L	2020
Preincision adjunctive prophylaxis for cesarean deliveries a systematic review and meta-analysis. American journal of obstetrics and gynecology, 2021, Volume: 225, Issue:4 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Cesarean Section; Drug Therapy, Combinatio	2021
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
Emerging concepts in antibiotic prophylaxis for cesarean delivery: a systematic review. Obstetrics and gynecology, 2009, Volume: 113, Issue:3 Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Cefazolin; Cesarean Section; Endometrit	2009
[Use of metronidazole and its analogs in obstetrical and gynecological practice]. Akusherstvo i ginekologiia, 1983, Issue:3 Topics: Bacteroides fragilis; Bacteroides Infections; Biological Availability; Clostridium Infections; Femal	1983
[Bacterial vaginosis]. Orvosi hetilap, 1998, Jun-07, Volume: 139, Issue:23 Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Clindamycin; Female; Humans; Metronidazole; Obstetric	1998
Antimicrobial agents in the treatment of obstetric and gynecologic infections. The Medical clinics of North America, 1974, Volume: 58, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Cephalosporins; Chloramphenicol; Erythrom	1974

Article	Year
Comparison of ceftriaxone versus triple drug regimen in the prevention of cesarean section infectious morbidities. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2008, Volume: 21, Issue:9 Topics: Adult; Ampicillin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ceftriaxone; Cesarean Section; Clo	2008
Choice of antibiotics for infection prophylaxis in emergency cesarean sections in low-income countries: a cost-benefit study in Mozambique. Acta obstetricia et gynecologica Scandinavica, 2003, Volume: 82, Issue:7 Topics: Adult; Antibiotic Prophylaxis; Cesarean Section; Cost-Benefit Analysis; Drug Administration Schedule	2003
[Perioperative short-term prevention of puerperal infections following cesarean section with metronidazole]. Geburtshilfe und Frauenheilkunde, 1984, Volume: 44, Issue:9 Topics: Cesarean Section; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Metronidazole; Preg	1984
Prophylactic and antimicrobial therapy using lincomycin in patients undergoing emergency caesarean section. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Jun-13, Volume: 59, Issue:25 Topics: Cesarean Section; Clinical Trials as Topic; Double-Blind Method; Emergencies; Female; Humans; Lincom	1981
[Antibiotic prophylaxis in a priori cesarean sections without a high risk of infection. Experiences of a Tunisian maternity department]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1994, Volume: 23, Issue:4 Topics: Adult; Anti-Bacterial Agents; Cephapirin; Cesarean Section; Drug Costs; Escherichia coli Infections;	1994
Single or triple dose piperacillin prophylaxis in elective cesarean section. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1998, Volume: 62, Issue:1 Topics: Anti-Infective Agents; Antibiotic Prophylaxis; Cephalosporins; Cephradine; Cesarean Section; Drug Ad	1998
An evaluation of metronidazole in the prophylaxis of anaerobic infections in obstetrical patients. The Journal of antimicrobial chemotherapy, 1978, Volume: 4 Suppl C Topics: Anaerobiosis; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Metronidazole; Pregnanc	1978
Metronidazole in the prevention and treatment of anaerobic sepsis. Annali dell'Istituto superiore di sanita, 1979, Volume: 15, Issue:1 Topics: Anaerobiosis; Appendectomy; Bacterial Infections; Cesarean Section; Clinical Trials as Topic; Colon;	1979
Prevention of postcesarean infectious morbidity with a single dose of intravenous metronidazole. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1991, Volume: 34, Issue:3 Topics: Adult; Cesarean Section; Endometritis; Female; Humans; Infusions, Intravenous; Metronidazole; Postop	1991
[Follow-up and wound healing following cesarean section with prophylactic use of Vagimid in comparison with the puerperal course without the use of Vagimid]. Zentralblatt fur Gynakologie, 1989, Volume: 111, Issue:7 Topics: Cesarean Section; Clinical Trials as Topic; Female; Humans; Metronidazole; Pregnancy; Prospective St	1989
Single dose prophylactic antibiotics in caesarean sections. The Australian & New Zealand journal of obstetrics & gynaecology, 1989, Volume: 29, Issue:2 Topics: Adult; Ampicillin; Cesarean Section; Double-Blind Method; Female; Humans; Maternal Age; Metronidazol	1989
[Comparative clinical study between Rocephin (Roche) and doxycycline, amoxycillin, erythromycin and amoxycillin + metronidazole combination in gynecology]. Gynakologische Rundschau, 1985, Volume: 25, Issue:2 Topics: Abscess; Adult; Aged; Amoxicillin; Breast Diseases; Cefotaxime; Ceftriaxone; Clinical Trials as Topi	1985
[Treatment of trichomoniasis during puerperium]. Wiadomosci parazytologiczne, 1969, Volume: 15, Issue:3 Topics: Antitrichomonal Agents; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Metronidazole; Pre	1969

Article	Year
Antibiotic Recommendations After Postpartum Uterine Exploration or Instrumentation. Obstetrical & gynecological survey, 2023, Volume: 78, Issue:7 Topics: Ampicillin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Endometritis; Female; Humans;	2023
Pelvic abscess in gynecologic patients. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1981, Volume: 19, Issue:3 Topics: Abortion, Induced; Abortion, Spontaneous; Abscess; Adolescent; Adult; Anti-Bacterial Agents; Female;	1981
[Treatment of the complications of an anaerobic infection in obstetrics and gynecology using metronidazole (Flagyl)]. Akusherstvo i ginekologiia, 1984, Volume: 23, Issue:4 Topics: Bacteria, Anaerobic; Bacterial Infections; Cesarean Section; Drug Evaluation; Female; Humans; Hyster	1984
[Metranidazole and breast feeding. Should a mother breast-feed her child while under metranidazole therapy for puerperal infections?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1984, Sep-10, Volume: 104, Issue:25 Topics: Breast Feeding; Female; Humans; Infant, Newborn; Metronidazole; Milk, Human; Pregnancy; Puerperal In	1984
[Etiologic aspects of puerperal endometritis and its etiotropic treatment]. Akusherstvo i ginekologiia, 1983, Issue:12 Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Endometritis; Female;	1983
[Metronidazole in the treatment and prevention of infections in gynecology and obstetrics]. Zentralblatt fur Gynakologie, 1983, Volume: 105, Issue:10 Topics: Bacterial Infections; Biotransformation; Female; Humans; Maternal-Fetal Exchange; Metabolic Clearanc	1983
Puerperal sepsis in Port Moresby, Papua New Guinea. Papua and New Guinea medical journal, 1980, Volume: 23, Issue:3 Topics: Bacteroides Infections; Chloramphenicol; Escherichia coli Infections; Female; Humans; Metronidazole;	1980
[Use of metronidazole in treatment of postoperative obstetric infections (author's transl)]. Zentralblatt fur Gynakologie, 1981, Volume: 103, Issue:13 Topics: Abscess; Adolescent; Adult; Cesarean Section; Drug Administration Schedule; Female; Humans; Metronid	1981
Isolation and antimicrobial susceptibility of obligate anaerobic bacteria recovered from the uteri of dairy cows with retained fetal membranes and postparturient endometritis. Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 1996, Volume: 43, Issue:4 Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Cattle; Cattle Diseases; Ciprofloxacin; Clindam	1996
Anaerobic subareolar breast abscess. Lancet (London, England), 1979, Jan-06, Volume: 1, Issue:8106 Topics: Abscess; Adult; Ampicillin; Bacteroides; Bacteroides Infections; Drainage; Female; Humans; Mastitis;	1979
The role of anaerobic bacteria in postpartum endomyometritis. American journal of obstetrics and gynecology, 1979, Nov-15, Volume: 135, Issue:6 Topics: Anaerobiosis; Bacteria; Drug Resistance, Microbial; Endometritis; Evaluation Studies as Topic; Femal	1979
Metronidazole in obstetrics and gynaecology. The Journal of antimicrobial chemotherapy, 1978, Volume: 4 Suppl C Topics: Anaerobiosis; Cesarean Section; Drug Administration Schedule; Female; Humans; Hysterectomy; Metronid	1978
A new approach to patients with suspected anaerobic postpartum pelvic infections. Transabdominal uterine aspiration for culture and metronidazole for treatment. American journal of obstetrics and gynecology, 1976, Sep-01, Volume: 126, Issue:1 Topics: Abdomen; Adult; Anaerobiosis; Bacteria; Endometritis; Female; Humans; Metronidazole; Pregnancy; Puer	1976
[Effect of metronidazole administration after cesarean section. A 1-year prospective study from November 1987 to October 1988]. Ceskoslovenska gynekologie, 1990, Volume: 55, Issue:4 Topics: Cesarean Section; Female; Humans; Metronidazole; Postoperative Care; Pregnancy; Prospective Studies;	1990
Atypical postpartum psychosis possibly associated with metronidazole therapy. The Journal of family practice, 1988, Volume: 27, Issue:3 Topics: Adult; Dysentery, Amebic; Female; Humans; Infant, Newborn; Laos; Metronidazole; Pregnancy; Psychoses	1988
[Present-day etiology and antibacterial therapy of puerperal endometritis]. Akusherstvo i ginekologiia, 1988, Issue:4 Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Endometritis; Female; Humans	1988
[Significance of the treatment of trichomoniasis in gynecology and obstetrics]. Wiadomosci parazytologiczne, 1969, Volume: 15, Issue:3 Topics: Abortion, Spontaneous; Antiprotozoal Agents; Antitrichomonal Agents; Appendicitis; Female; Humans; M	1969

metronidazole and Infection, Puerperal