metronidazole has been researched along with Mediastinal Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Mediastinal Diseases: Disorders of the mediastinum, general or unspecified.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lemierre's syndrome is a rare disease in young otherwise healthy people showing septic embolism in the lungs and peripheral vessels." | 1.36 | [Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome]. ( Braunbeck, A; Daecke, W; Fiebig, C; Geiger, EV; Maier, M; Marzi, I; Weber, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anwuzia-Iwegbu, C | 1 |
| Al Omran, Y | 1 |
| Heaford, A | 1 |
| Braunbeck, A | 1 |
| Geiger, EV | 1 |
| Weber, R | 1 |
| Maier, M | 1 |
| Daecke, W | 1 |
| Fiebig, C | 1 |
| Marzi, I | 1 |
| Coss, KC | 1 |
| Wheat, LJ | 1 |
| Conces, DJ | 1 |
| Brashear, RE | 1 |
| Hull, MT | 1 |
3 other studies available for metronidazole and Mediastinal Diseases
| Article | Year |
|---|---|
Against all odds. Conservative management of Boerhaave's syndrome.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Antifungal Agents; Drainage; E | 2014 |
[Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome].
Topics: Abscess; Acromioclavicular Joint; Anti-Bacterial Agents; Cellulitis; Combined Modality Therapy; Diag | 2010 |
Esophageal fistula complicating mediastinal histoplasmosis. Response to amphotericin B.
Topics: Adult; Amphotericin B; Ceftriaxone; Drug Therapy, Combination; Esophageal Fistula; Hemoptysis; Histo | 1987 |