metronidazole has been researched along with Pericoronitis in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pericoronitis: Inflammation of the gingiva surrounding the crown of a tooth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Amoxicillin was the most frequently prescribed antibiotic used for most clinical conditions apart from pericoronitis, acute ulcerative gingivitis and dry sockets where metronidazole was the drug of choice." | 3.70 | A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. ( Ireland, RS; Martin, MV; Palmer, NA; Pealing, R, 2000) |
| "Metronidazole has important interactions with alcohol, disulfiram and warfarin and there are contraindications to its use." | 2.37 | Metronidazole: its use in clinical dentistry. ( Mitchell, DA, 1984) |
| "Acute pericoronitis is a common oral infection characterised by a predominance of anaerobic micro-organisms such as peptococci, peptostreptococci, bacteroides and fusobacteria, and also spirochaetes." | 1.28 | British oral and maxillofacial surgeons' views on the aetiology and management of acute pericoronitis. ( Gill, Y; Scully, C, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sixou, JL | 1 |
| Magaud, C | 1 |
| Jolivet-Gougeon, A | 1 |
| Cormier, M | 1 |
| Bonnaure-Mallet, M | 1 |
| Bergdahl, M | 1 |
| Hedström, L | 1 |
| Brescó-Salinas, M | 1 |
| Costa-Riu, N | 1 |
| Berini-Aytés, L | 1 |
| Gay-Escoda, C | 1 |
| Mitchell, DA | 1 |
| Palmer, NA | 1 |
| Pealing, R | 1 |
| Ireland, RS | 1 |
| Martin, MV | 1 |
| Hood, FJ | 1 |
| McGowan, DA | 1 |
| Murphy, KJ | 1 |
| Sheiham, A | 1 |
| Gill, Y | 1 |
| Scully, C | 1 |
| Barclay, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893] | 157 participants (Actual) | Interventional | 2019-06-07 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Pericoronitis
| Article | Year |
|---|---|
Metronidazole: its use in clinical dentistry.
Topics: Aggressive Periodontitis; Bacteria, Anaerobic; Drug Interactions; Gingivitis; Humans; Kinetics; Metr | 1984 |
3 trials available for metronidazole and Pericoronitis
| Article | Year |
|---|---|
Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Chi-Square Distribution; Contracepti | 2004 |
The place of metronidazole in the treatment of acute oro-facial infection.
Topics: Acute Disease; Anaerobiosis; Clinical Trials as Topic; Humans; Metronidazole; Microbial Sensitivity | 1978 |
Metronidazole in the treatment of severe acute pericoronitis. A clinical trail.
Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; M | 1977 |
5 other studies available for metronidazole and Pericoronitis
| Article | Year |
|---|---|
Microbiology of mandibular third molar pericoronitis: incidence of beta-lactamase-producing bacteria.
Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacteroides; beta-Lactam | 2003 |
Antibiotic susceptibility of the bacteria causing odontogenic infections.
Topics: Acetamides; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bact | 2006 |
A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England.
Topics: Abscess; Acute Disease; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infecti | 2000 |
British oral and maxillofacial surgeons' views on the aetiology and management of acute pericoronitis.
Topics: Acute Disease; Administration, Oral; Anti-Bacterial Agents; Attitude of Health Personnel; Bacterial | 1991 |
Metronidazole and dry socket: prophylactic use in mandibular third molar removal complicated by non-acute pericoronitis.
Topics: Adolescent; Adult; Dry Socket; Female; Humans; Male; Metronidazole; Middle Aged; Molar, Third; Peric | 1987 |