metronidazole has been researched along with Rectovaginal Fistula in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rectovaginal Fistula: An abnormal anatomical passage between the RECTUM and the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rectovaginal fistulas secondary to ulcerative colitis may be treated by ileoanal pouch anastomosis and primary repair." | 2.38 | Perianal inflammatory conditions in inflammatory bowel disease. ( Gordon, PH; Stein, BL, 1993) |
| "Genital fistulas are a significant problem in female Crohn's disease patients." | 1.38 | Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy. ( Bermejo, F; de la Poza, G; Gisbert, JP; López-Sanroman, A; Marín-Jimenez, I; Muriel, A; Opio, V; Taxonera, C, 2012) |
| "Crohn disease is a chronic inflammatory disease characterized by sharply demarcated segments of gastrointestinal involvement from mouth to anus." | 1.33 | Perianal Crohn disease. ( Asma, SD; Kahena, J; Nejib, D; Raouf, DM; Soumaya, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iesalnieks, I | 1 |
| Glass, H | 1 |
| Kilger, A | 1 |
| Ott, C | 1 |
| Klebl, F | 1 |
| Agha, A | 1 |
| Schlitt, HJ | 1 |
| Strauch, U | 1 |
| de la Poza, G | 1 |
| López-Sanroman, A | 1 |
| Taxonera, C | 1 |
| Marín-Jimenez, I | 1 |
| Gisbert, JP | 1 |
| Bermejo, F | 1 |
| Opio, V | 1 |
| Muriel, A | 1 |
| Asma, SD | 1 |
| Soumaya, Y | 1 |
| Kahena, J | 1 |
| Raouf, DM | 1 |
| Nejib, D | 1 |
| Atienza, P | 1 |
| Stein, BL | 1 |
| Gordon, PH | 1 |
| Fadiran, OA | 1 |
| Dare, FO | 1 |
| Jeje, EA | 1 |
| Nwosu, SO | 1 |
| Oyero, TO | 1 |
| Malchow, H | 1 |
3 reviews available for metronidazole and Rectovaginal Fistula
| Article | Year |
|---|---|
[Refractory perineal fistulas in Crohn's disease].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Ciprofloxacin; Crohn Diseas | 2007 |
Perianal inflammatory conditions in inflammatory bowel disease.
Topics: Abscess; Adult; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease; Female; Humans; Male; | 1993 |
Amoebic recto-vaginal fistula--a case report and review of literature.
Topics: Adult; Biopsy; Colostomy; Combined Modality Therapy; Dysentery, Amebic; Female; Humans; Metronidazol | 1993 |
4 other studies available for metronidazole and Rectovaginal Fistula
| Article | Year |
|---|---|
[Perianal fistulas in Crohn's disease: treatment results at an interdisciplinary unit].
Topics: Abscess; Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; | 2009 |
Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents; Antibod | 2012 |
Perianal Crohn disease.
Topics: Adult; Anti-Bacterial Agents; Azathioprine; Cefotaxime; Crohn Disease; Female; Humans; Immunosuppres | 2006 |
[Fistulas in Crohn disease--conservative versus operative treatment. The internist viewpoint].
Topics: Adolescent; Adult; Child; Combined Modality Therapy; Crohn Disease; Female; Humans; Intestinal Fistu | 1985 |