Page last updated: 2024-10-31

metronidazole and Precancerous Conditions

metronidazole has been researched along with Precancerous Conditions in 7 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Precancerous Conditions: Pathological conditions that tend eventually to become malignant.

Research Excerpts

ExcerptRelevanceReference
"Among the 18 new cases of gastric cancers that developed, no overall reduction was observed in participants who received H pylori eradication treatment (n = 7) compared with those who did not (n = 11) (P =."2.71Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. ( Chen, JS; Ching, CK; Feng, RE; Fong, DY; Ho, J; Hu, WH; Lai, KC; Lam, SK; Leung, SY; Wong, BC; Wong, WM; Yuen, ST; Zheng, TT, 2004)
"pylori-induced gastric cancer, irrespective of the timing of antibiotic administration."1.42Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model. ( Aponte-Pieras, JR; Lee, DS; Morrissey, R; Moss, SF; Rogers, AB; Zhang, S, 2015)
"Endoscopy after ER detected no new gastric cancers in these patients."1.30Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. ( Haruma, K; Kajiyama, G; Mashiba, H; Mukai, T; Okamoto, S; Sasaki, N; Sumii, K; Taniyama, K; Uemura, N; Yamaguchi, S, 1997)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's2 (28.57)18.2507
2000's3 (42.86)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, S1
Lee, DS1
Morrissey, R1
Aponte-Pieras, JR1
Rogers, AB1
Moss, SF1
Wong, BC1
Lam, SK1
Wong, WM1
Chen, JS2
Zheng, TT1
Feng, RE1
Lai, KC1
Hu, WH1
Yuen, ST1
Leung, SY1
Fong, DY1
Ho, J1
Ching, CK1
Camargo, MC1
Piazuelo, MB1
Mera, RM1
Fontham, ET1
Delgado, AG1
Yepez, MC1
Ceron, C1
Bravo, LE2
Bravo, JC2
Correa, P2
Muñoz, N1
Vivas, J1
Buiatti, E1
Kato, I1
Oliver, W1
Uemura, N1
Mukai, T1
Okamoto, S1
Yamaguchi, S1
Mashiba, H1
Taniyama, K1
Sasaki, N1
Haruma, K1
Sumii, K1
Kajiyama, G1
van Doorn, LJ1
Ruiz, B1
Realpe, JL1
Minucci, D1
Guida, G1
Rabasso, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Hybrid and Bismuth Containing Quadruple Therapies for Helicobacter Pylori Eradication: a Randomized Controlled Trial[NCT02541864]330 participants (Actual)Interventional2013-07-31Completed
Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection - a Randomized Controlled Trial (REHYTRI Study)[NCT02359435]440 participants (Actual)Interventional2012-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants in Which H. Pylori Was Eradicated

Repeated endoscopy with rapid urease test, histological examination and culture or urea breath tests are conducted to assess H. pylori status. (NCT02541864)
Timeframe: at the 6th week after the end of anti- H. pylori therapy

Interventionparticipants (Number)
Pantoprazole+Bismuth+Tetra+Metro154
Hybrid Therapy154

Number of Participants in Which H. Pylori Was Eradicated

Evaluate eradication outcome by endoscopy urease test and histology or urea breath test (NCT02359435)
Timeframe: at the 6th week after the end of anti- H. pylori therapy

Interventionparticipants (Number)
Reverse Hybrid Therapy206
Standard Triple Therapy191

Trials

2 trials available for metronidazole and Precancerous Conditions

ArticleYear
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
    JAMA, 2004, Jan-14, Volume: 291, Issue:2

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin

2004
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
    JAMA, 2004, Jan-14, Volume: 291, Issue:2

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin

2004
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
    JAMA, 2004, Jan-14, Volume: 291, Issue:2

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin

2004
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
    JAMA, 2004, Jan-14, Volume: 291, Issue:2

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Anti-Ulcer Agents; Chin

2004
Chemoprevention trial on precancerous lesions of the stomach in Venezuela: summary of study design and baseline data.
    IARC scientific publications, 1996, Issue:139

    Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anticarcinogenic Agents; Antioxidants; Clarithromyc

1996

Other Studies

5 other studies available for metronidazole and Precancerous Conditions

ArticleYear
Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model.
    Cancer letters, 2015, Apr-10, Volume: 359, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Chemokine CXCL10; Chemokine CXCL9; Clarithromycin; Gastric Mucosa; G

2015
Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia.
    Acta gastroenterologica Latinoamericana, 2007, Volume: 37, Issue:4

    Topics: Amoxicillin; Anti-Infective Agents; Bismuth; Colombia; Drug Therapy, Combination; Female; Follow-Up

2007
Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Biopsy; Clarithromycin; Combined Modality Therapy; Dose

1997
Unsuccessful treatment results in survival of less virulent genotypes of Helicobacter pylori in Colombian patients.
    The American journal of gastroenterology, 2000, Volume: 95, Issue:2

    Topics: Amoxicillin; Antacids; Anti-Bacterial Agents; Bismuth; Chemoprevention; Colombia; Follow-Up Studies;

2000
[Dysplasia and carcinoma in situ of the uterine cervix. Outcome of several cases].
    Minerva ginecologica, 1975, Volume: 27, Issue:5

    Topics: Adult; Antineoplastic Agents; Carcinoma in Situ; Female; Humans; Metronidazole; Nystatin; Precancero

1975