metronidazole has been researched along with B. burgdorferi Infection in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Moreover, the interruption of the disease progression after the antibiotic therapy is difficult to ignore without claiming that this association is at least suggestive." | 1.42 | Parry-Romberg syndrome: a case with a possible association with Lyme disease. ( di Meo, N; Nan, K; Pinzani, C; Stinco, G; Trevisan, G, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edson, RS | 1 |
| Litin, SC | 1 |
| Bundrick, JB | 1 |
| Caol, S | 1 |
| Divers, T | 1 |
| Crisman, M | 1 |
| Chang, YF | 1 |
| di Meo, N | 1 |
| Stinco, G | 1 |
| Nan, K | 1 |
| Pinzani, C | 1 |
| Trevisan, G | 1 |
| Savely, G | 1 |
4 other studies available for metronidazole and B. burgdorferi Infection
| Article | Year |
|---|---|
Clinical Pearls in Infectious Diseases 2017.
Topics: Administration, Intravaginal; Adult; Aged; Anti-Bacterial Agents; Body Piercing; Campylobacter Infec | 2017 |
In vitro susceptibility of Borrelia burgdorferi isolates to three antibiotics commonly used for treating equine Lyme disease.
Topics: Animals; Anti-Bacterial Agents; Borrelia burgdorferi; Cephalosporins; Horse Diseases; Horses; Lyme D | 2017 |
Parry-Romberg syndrome: a case with a possible association with Lyme disease.
Topics: Adolescent; Albania; Anti-Infective Agents; Borrelia burgdorferi; Disease Progression; Face; Facial | 2015 |
Neuralgia and demyelinating plaques: MS or lyme disease?
Topics: Anti-Bacterial Agents; Antigens, Bacterial; Blotting, Western; Borrelia burgdorferi; Ceftriaxone; Di | 2005 |