metronidazole has been researched along with Disbacteriosis in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe the outcome of dietary management of canine noninfectious acute colitis with or without concurrent oral administration of metronidazole using a randomized controlled clinical trial." | 9.51 | Randomized controlled trial demonstrates nutritional management is superior to metronidazole for treatment of acute colitis in dogs. ( Bremer, CA; Cooper, E; Howard, JP; Laxalde, J; Marsh, A; Mathie, T; Parker, VJ; Perea, S; Rudinsky, AJ; Suchodolski, J; Winston, J; Yaxley, P, 2022) |
| "To describe the outcome of dietary management of canine noninfectious acute colitis with or without concurrent oral administration of metronidazole using a randomized controlled clinical trial." | 5.51 | Randomized controlled trial demonstrates nutritional management is superior to metronidazole for treatment of acute colitis in dogs. ( Bremer, CA; Cooper, E; Howard, JP; Laxalde, J; Marsh, A; Mathie, T; Parker, VJ; Perea, S; Rudinsky, AJ; Suchodolski, J; Winston, J; Yaxley, P, 2022) |
| "The standard treatment for bacterial vaginosis (BV) with oral metronidazole is often ineffective, and recurrence rates are high among African women." | 1.62 | Temporal Changes in Vaginal Microbiota and Genital Tract Cytokines Among South African Women Treated for Bacterial Vaginosis. ( Abdool Karim, Q; Abdool Karim, SS; Balle, C; de Oliveira, T; Garrett, N; Giandhari, J; Jaspan, HB; Liebenberg, LJP; Mindel, A; Mngomezulu, K; Mtshali, A; Mzobe, G; Ngcapu, S; Onywera, H; Osman, F; Passmore, JS; Ravel, J; Rompalo, A; San, JE, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Mtshali, A | 1 |
| San, JE | 1 |
| Osman, F | 1 |
| Garrett, N | 1 |
| Balle, C | 1 |
| Giandhari, J | 1 |
| Onywera, H | 1 |
| Mngomezulu, K | 1 |
| Mzobe, G | 1 |
| de Oliveira, T | 1 |
| Rompalo, A | 1 |
| Mindel, A | 1 |
| Abdool Karim, SS | 1 |
| Ravel, J | 1 |
| Passmore, JS | 1 |
| Abdool Karim, Q | 1 |
| Jaspan, HB | 1 |
| Liebenberg, LJP | 1 |
| Ngcapu, S | 1 |
| Huang, C | 1 |
| Feng, S | 1 |
| Huo, F | 1 |
| Liu, H | 1 |
| Kinoshita, Y | 1 |
| Niwa, H | 1 |
| Uchida-Fujii, E | 1 |
| Nukada, T | 1 |
| Ueno, T | 1 |
| Rudinsky, AJ | 1 |
| Parker, VJ | 1 |
| Winston, J | 1 |
| Cooper, E | 1 |
| Mathie, T | 1 |
| Howard, JP | 1 |
| Bremer, CA | 1 |
| Yaxley, P | 1 |
| Marsh, A | 1 |
| Laxalde, J | 1 |
| Suchodolski, J | 1 |
| Perea, S | 1 |
| Zhou, Y | 2 |
| Ye, Z | 1 |
| Lu, J | 1 |
| Miao, S | 1 |
| Lu, X | 1 |
| Sun, H | 1 |
| Wu, J | 1 |
| Wang, Y | 2 |
| Huang, Y | 1 |
| Strati, F | 1 |
| Pujolassos, M | 1 |
| Burrello, C | 1 |
| Giuffrè, MR | 1 |
| Lattanzi, G | 1 |
| Caprioli, F | 1 |
| Troisi, J | 1 |
| Facciotti, F | 1 |
| Hatcher, J | 1 |
| Williamson, L | 1 |
| Okamoto, K | 1 |
| Watanabe, T | 1 |
| Komeda, Y | 1 |
| Okamoto, A | 1 |
| Minaga, K | 1 |
| Kamata, K | 1 |
| Yamao, K | 1 |
| Takenaka, M | 1 |
| Hagiwara, S | 1 |
| Sakurai, T | 1 |
| Tanaka, T | 1 |
| Sakamoto, H | 1 |
| Fujimoto, K | 1 |
| Nishida, N | 1 |
| Kudo, M | 1 |
| Hsu, PI | 1 |
| Pan, CY | 1 |
| Kao, JY | 1 |
| Tsay, FW | 1 |
| Peng, NJ | 1 |
| Kao, SS | 1 |
| Wang, HM | 1 |
| Tsai, TJ | 1 |
| Wu, DC | 1 |
| Chen, CL | 1 |
| Tsai, KW | 1 |
| Ishikawa, D | 2 |
| Sasaki, T | 2 |
| Takahashi, M | 1 |
| Kuwahara-Arai, K | 2 |
| Haga, K | 2 |
| Ito, S | 1 |
| Okahara, K | 1 |
| Nakajima, A | 1 |
| Shibuya, T | 2 |
| Osada, T | 2 |
| Hiramatsu, K | 2 |
| Watanabe, S | 2 |
| Nagahara, A | 1 |
| Zhang, Y | 1 |
| Ran, Z | 1 |
| Tian, M | 1 |
| Yang, J | 1 |
| Yin, J | 1 |
| Lu, D | 1 |
| Li, R | 1 |
| Zhong, J | 1 |
| Steven Esworthy, R | 1 |
| Kim, BW | 1 |
| Gao, Q | 1 |
| Doroshow, JH | 1 |
| Leto, TL | 1 |
| Chu, FF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Precision Medicine in Systemic Sclerosis Gastrointestinal Disease: Evaluating Imaging and Stool Biomarkers for Differentiating Disease Stages and Treatment Responses[NCT04630782] | 70 participants (Anticipated) | Observational | 2020-04-09 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Disbacteriosis
| Article | Year |
|---|---|
Randomized controlled trial demonstrates nutritional management is superior to metronidazole for treatment of acute colitis in dogs.
Topics: Animals; Colitis; Cryptosporidiosis; Cryptosporidium; Dog Diseases; Dogs; Dysbiosis; Metronidazole; | 2022 |
Changes in Intestinal Microbiota Following Combination Therapy with Fecal Microbial Transplantation and Antibiotics for Ulcerative Colitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Colitis, Ulcerative; Colon; Colonoscopy; Combined M | 2017 |
11 other studies available for metronidazole and Disbacteriosis
| Article | Year |
|---|---|
Temporal Changes in Vaginal Microbiota and Genital Tract Cytokines Among South African Women Treated for Bacterial Vaginosis.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Bacteria; Cytokines; Dysbiosis; Female; Host-Pat | 2021 |
Effects of Four Antibiotics on the Diversity of the Intestinal Microbiota.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Bacteria; Dysbiosis; Gastrointestinal Microbiome; Humans | 2022 |
Simultaneous Daily Fecal Microbiota Transplantation Fails to Prevent Metronidazole-Induced Dysbiosis of Equine Gut Microbiota.
Topics: Animals; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Horse Dise | 2022 |
Long-term changes in the gut microbiota after 14-day bismuth quadruple therapy in penicillin-allergic children.
Topics: Adolescent; Anti-Bacterial Agents; Bismuth; Child; Clarithromycin; Cross-Sectional Studies; Drug Hyp | 2020 |
Antibiotic-associated dysbiosis affects the ability of the gut microbiota to control intestinal inflammation upon fecal microbiota transplantation in experimental colitis models.
Topics: Animals; Anti-Bacterial Agents; Colitis; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transpl | 2021 |
Noma in a patient with HIV.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-HIV Agents; Antire | 2017 |
Dysbiosis-Associated Polyposis of the Colon-Cap Polyposis.
Topics: Ampicillin; Anti-Bacterial Agents; Asymptomatic Diseases; Bacteria; Colon; Colonic Polyps; Dysbiosis | 2018 |
Helicobacter pylori eradication with bismuth quadruple therapy leads to dysbiosis of gut microbiota with an increased relative abundance of Proteobacteria and decreased relative abundances of Bacteroidetes and Actinobacteria.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Actinobacteria; Adult; Anti-Bacterial Agents; Bacteroidetes | 2018 |
The Microbial Composition of Bacteroidetes Species in Ulcerative Colitis Is Effectively Improved by Combination Therapy With Fecal Microbiota Transplantation and Antibiotics.
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroidetes; Colitis, Ulcerative; Combined Modality Therapy; D | 2018 |
Commensal Microbes Affect Host Humoral Immunity to
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacteroidetes; Bordetella pertuss | 2019 |
The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.
Topics: Alleles; Animals; Apoptosis; Cell Proliferation; Colitis; Cyclooxygenase 2; Dysbiosis; Epithelial Ce | 2013 |