calvatic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Calvatic acid is a natural product with a unique structure that has drawn attention for its potential medicinal properties. It has been isolated from the fruiting bodies of various fungi, including *Calvatia gigantea*, the giant puffball mushroom. Research on calvatic acid is still ongoing, and its exact mechanisms of action and therapeutic potential are being explored. Studies have shown it to exhibit antimicrobial and anti-inflammatory activities, making it a promising candidate for drug development. The compound's synthesis remains challenging, with scientists investigating various approaches to obtain it efficiently. The complexity of its structure and its potential therapeutic benefits drive ongoing research into its isolation, synthesis, and pharmacological properties.'

calvatic acid: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	99679
CHEMBL ID	131824
MeSH ID	M0055301

Synonyms (15)

Synonym
nsc264713
nsc-264713
calvatic acid
54723-08-9
benzoic acid, 4-(cyano-nno-azoxy)-
NCI60_002121
p-carboxyphenylazoxycyanide
CHEMBL131824
(4-carboxyphenyl)-cyanoimino-oxidoazanium
AKOS006276191
LDRFVNKBORCKQS-UHFFFAOYSA-N
4-carboxy-n-(cyanoimino)benzen-1-imine oxide
4-carboxy-n-(cyanoimino)benzen-1-imineoxide
EN300-300167
AKOS040734763

Research Excerpts

Overview

Calvatic acid is a new antibiotic with both a carboxylic group and an azoxy function in the benzene ring.

Excerpt	Reference	Relevance
"Calvatic acid is a new antibiotic with both a carboxylic group and an azoxy function in the benzene ring. "	( Some biological effects of calvatic acid and its analog on isolated hepatocytes. Chiarpotto, E; Gabriel, L; Gadoni, E; Miglietta, A; Olivero, A, 1987)	2.01

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID88245	Minimal concentration needed to inhibit 50% of Helicobacter pylori strain	2001	Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3	Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
AID88248	Minimal concentration needed to inhibit 90% of Helicobacter pylori strain	2001	Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3	Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
AID87947	Inhibitory activity was determined against NCTC-11637 strain of Helicobacter pylori	2001	Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3	Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
AID87949	Minimal concentration needed to inhibitH. pylori strain	2001	Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3	Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
AID87946	Inhibitory activity was determined against 102R strain of Helicobacter pylori	2001	Bioorganic & medicinal chemistry letters, Feb-12, Volume: 11, Issue:3	Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (33.33)	18.7374
1990's	4 (44.44)	18.2507
2000's	2 (22.22)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.92 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.92)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
histamine [no description available]	2	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.41	2	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
cyanides Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.	1.99	1	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.37	2	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2	1	1,2,3-triazole
lamtidine lamtidine: structure given in first source	2	1	aromatic amine
piperidines Piperidines: A family of hexahydropyridines.	2	1

Condition	Relationship Strength	Studies
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.39	2
Di Guglielmo Disease [description not available]	1.97	1
Experimental Hepatoma [description not available]	2.38	2
Leukemia, Erythroblastic, Acute A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.	1.97	1

chemdatabank.com