metronidazole has been researched along with Abdominal Injuries in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Abdominal Injuries: General or unspecified injuries involving organs in the abdominal cavity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether a combination of ciprofloxacin hydrochloride and metronidazole hydrochloride would be as effective or more effective than a combination of gentamicin sulfate and metronidazole hydrochloride for preventing infection in patients with penetrating abdominal trauma, to evaluate the factors associated with increased risk of infection, and to determine the serum peak and trough levels of gentamicin with the dosage regimen of 2." | 5.08 | A trial of ciprofloxacin and metronidazole vs gentamicin and metronidazole for penetrating abdominal trauma. ( McCreadie, S; Tyburski, JG; Warsow, KM; Wilson, RF, 1998) |
| "5 g, every 6 hours) were compared with combined gentamicin (80 mg, every 8 hours) and metronidazole (500 mg every 6 hours) therapy in 246 patients hospitalized for penetrating abdominal injuries." | 5.07 | Piperacillin monotherapy compared with metronidazole and gentamicin combination in penetrating abdominal trauma. ( Ganesan, N; Lou, MA; Sims, EH; Thadepalli, H; Williams, SW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Fan, P | 1 |
| Chu, J | 1 |
| Yang, J | 1 |
| Yang, X | 1 |
| Zhang, L | 1 |
| Guo, C | 1 |
| Exadaktylos, A | 1 |
| Stettbacher, A | 1 |
| Edul, S | 1 |
| Nichols, A | 1 |
| Bautz, P | 1 |
| Romero Ganuza, FJ | 1 |
| Gorbach, SL | 1 |
| McGowan, K | 1 |
| Sims, EH | 2 |
| Lou, MA | 1 |
| Williams, SW | 1 |
| Ganesan, N | 1 |
| Thadepalli, H | 3 |
| Ganesan, K | 1 |
| Mandal, AK | 1 |
| Tyburski, JG | 1 |
| Wilson, RF | 1 |
| Warsow, KM | 1 |
| McCreadie, S | 1 |
3 reviews available for metronidazole and Abdominal Injuries
| Article | Year |
|---|---|
[Pancreatitis associated with metronidazole].
Topics: Abdominal Injuries; Acute Disease; Adult; Anti-Bacterial Agents; Cervical Vertebrae; Clostridium Inf | 2008 |
Comparative clinical trials in treatment of intra-abdominal sepsis.
Topics: Abdomen; Abdominal Injuries; Abscess; Amikacin; Animals; Bacterial Infections; Carbenicillin; Cefama | 1981 |
Principles and practice of antibiotic therapy for post-traumatic abdominal injuries.
Topics: Abdomen; Abdominal Injuries; Aminoglycosides; Anti-Bacterial Agents; Antisepsis; Asepsis; Cephalospo | 1979 |
6 trials available for metronidazole and Abdominal Injuries
| Article | Year |
|---|---|
A contrast study of Dermacyn on enterocoely irrigate to control intraoperative infection.
Topics: Abdominal Injuries; Adolescent; Adult; Aged; Anti-Infective Agents, Local; Ascitic Fluid; C-Reactive | 2017 |
Comparative clinical trials in treatment of intra-abdominal sepsis.
Topics: Abdomen; Abdominal Injuries; Abscess; Amikacin; Animals; Bacterial Infections; Carbenicillin; Cefama | 1981 |
Piperacillin monotherapy compared with metronidazole and gentamicin combination in penetrating abdominal trauma.
Topics: Abdominal Injuries; Adolescent; Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination | 1993 |
How many antibiotics are necessary to treat abdominal trauma victims?
Topics: Abdominal Injuries; Adolescent; Adult; Antibiotic Prophylaxis; Cefoperazone; Ceftriaxone; Cephalospo | 1997 |
A trial of ciprofloxacin and metronidazole vs gentamicin and metronidazole for penetrating abdominal trauma.
Topics: Abdominal Injuries; Adult; Anti-Infective Agents; Ciprofloxacin; Double-Blind Method; Drug Therapy, | 1998 |
Principles and practice of antibiotic therapy for post-traumatic abdominal injuries.
Topics: Abdomen; Abdominal Injuries; Aminoglycosides; Anti-Bacterial Agents; Antisepsis; Asepsis; Cephalospo | 1979 |
1 other study available for metronidazole and Abdominal Injuries
| Article | Year |
|---|---|
[Successful management of abdominal stab wounds with clinical evaluation: experiences of an South-African trauma unit with 496 consecutive patients].
Topics: Abdominal Injuries; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Confidence | 2003 |