metronidazole has been researched along with Bacterial Meningitides in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 34-year-old Hispanic man with cirrhosis and hepatitis C being treated with metronidazole for Bacteroides fragilis meningitis and bacteremia developed ataxia, disorientation, and peripheral neuropathy." | 3.70 | Toxic metronidazole-induced MRI changes. ( Horlen, CK; Malouf, CS; Seifert, CF, 2000) |
| "A 61-year-old man with chronic hepatitis B and dyslipidemia visited the emergency department with a fever and severe headache." | 1.42 | Bacteremic meningitis caused by Parvimonas micra in an immunocompetent host. ( Baek, JY; Cho, SY; Chung, DR; Ha, YE; Kang, CI; Kim, SH; Ko, JH; Lee, JY; Lee, NY; Lee, WJ; Peck, KR; Song, JH, 2015) |
| "Anaerobic bacterial meningitis due to this pathogen is rarely diagnosed and if present, a predisposing source of infection should be actively sought for." | 1.29 | Bacteroides fragilis meningitis. ( Ngan, CC; Tan, AL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Overby, PJ | 1 |
| Mehta, H | 1 |
| Denes, E | 1 |
| Cypierre, A | 1 |
| Vacquier, J | 1 |
| Matt, M | 1 |
| Weinbreck, P | 1 |
| Ko, JH | 1 |
| Baek, JY | 1 |
| Kang, CI | 1 |
| Lee, WJ | 1 |
| Lee, JY | 1 |
| Cho, SY | 1 |
| Ha, YE | 1 |
| Kim, SH | 1 |
| Chung, DR | 1 |
| Peck, KR | 1 |
| Lee, NY | 1 |
| Song, JH | 1 |
| Mittal, MK | 1 |
| Zimmerman, RA | 1 |
| Angelino, G | 1 |
| Cantarutti, N | 1 |
| Chiurchiù, S | 1 |
| Amodio, D | 1 |
| De Luca, M | 1 |
| Lancella, L | 1 |
| Coltella, L | 1 |
| Russo, C | 1 |
| Finocchi, A | 1 |
| Brook, I | 1 |
| Spitzer, C | 1 |
| Foltys, H | 1 |
| Lemmen, SW | 1 |
| Block, F | 1 |
| Ngan, CC | 1 |
| Tan, AL | 1 |
| Aucher, P | 1 |
| Saunier, JP | 1 |
| Grollier, G | 1 |
| Sebald, M | 1 |
| Fauchère, JL | 1 |
| Workman, MR | 1 |
| Price, EH | 1 |
| Bullock, P | 1 |
| Horlen, CK | 1 |
| Seifert, CF | 1 |
| Malouf, CS | 1 |
1 review available for metronidazole and Bacterial Meningitides
| Article | Year |
|---|---|
[Bacterial meningitis as a complication of Fusobacterium necroforum infection in adults].
Topics: Adult; Anti-Bacterial Agents; Blood Glucose; Cerebrospinal Fluid Proteins; Diagnosis, Differential; | 2003 |
10 other studies available for metronidazole and Bacterial Meningitides
| Article | Year |
|---|---|
Case 271: Metronidazole-induced Encephalopathy.
Topics: Anti-Bacterial Agents; Brain; Brain Diseases; Child; Fusobacterium Infections; Humans; Magnetic Reso | 2019 |
Meningitis due to Fusobacterium nucleatum after a kart crash.
Topics: Anti-Infective Agents; Athletic Injuries; Bacteremia; Bacterial Translocation; Bacterial Typing Tech | 2013 |
Bacteremic meningitis caused by Parvimonas micra in an immunocompetent host.
Topics: Anti-Bacterial Agents; Bacteremia; Bacteria, Anaerobic; Ceftriaxone; Dyslipidemias; Firmicutes; Gram | 2015 |
Meningitis and epidural abscess related to pansinusitis.
Topics: Bacteroidaceae Infections; Cefotaxime; Ceftriaxone; Child; Combined Modality Therapy; Consciousness | 2009 |
Fulminant Fusobacterium necrophorum meningitis in an immunocompetent adolescent.
Topics: Adolescent; Anti-Bacterial Agents; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Immu | 2012 |
Prevotella intermedia meningitis associated with cerebrospinal fluid leakage in an adolescent.
Topics: Adolescent; Bacteroidaceae Infections; Ceftriaxone; Cerebrospinal Fluid Otorrhea; Craniocerebral Tra | 2003 |
Bacteroides fragilis meningitis.
Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Cholesteatoma, Middle Ear; Ear Neoplasms; Human | 1994 |
Meningitis due to enterotoxigenic Bacteroides fragilis.
Topics: Antibodies, Bacterial; Antitrichomonal Agents; Bacteroides fragilis; Bacteroides Infections; Blottin | 1996 |
Salmonella meningitis and multiple cerebral abscesses in an infant.
Topics: Amoxicillin; Ampicillin; Brain Abscess; Cefotaxime; Chloramphenicol; Ciprofloxacin; Drug Therapy, Co | 1999 |
Toxic metronidazole-induced MRI changes.
Topics: Adult; Anti-Infective Agents; Brain; Hepatitis C; Humans; Liver Cirrhosis; Magnetic Resonance Imagin | 2000 |