metronidazole has been researched along with Diverticulitis in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Diverticulitis: Inflammation of a DIVERTICULUM or diverticula.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of cefotaxime and metronidazole has been suggested for the treatment of peritonitis." | 9.05 | Short-term antibiotherapy for peritonitis: prospective, randomized trial comparing cefotaxime-metronidazole and clindamycin-tobramycin. ( Béland, L; Biron, S; Bourque, RA; Brochu, G; Marceau, P; Piché, P; Potvin, M, 1984) |
| "The combination of cefotaxime and metronidazole has been suggested for the treatment of peritonitis." | 5.05 | Short-term antibiotherapy for peritonitis: prospective, randomized trial comparing cefotaxime-metronidazole and clindamycin-tobramycin. ( Béland, L; Biron, S; Bourque, RA; Brochu, G; Marceau, P; Piché, P; Potvin, M, 1984) |
| "Outpatient diverticulitis is commonly treated with either a combination of metronidazole and a fluoroquinolone (metronidazole-with-fluoroquinolone) or amoxicillin-clavulanate alone." | 4.02 | Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis : Two Nationwide Cohort Studies. ( Bartelt, LA; Edwards, JK; Gaber, CE; Kinlaw, AC; Lund, JL; Pate, V; Peacock Hinton, S; Peery, AF; Sandler, RS; Stürmer, T, 2021) |
| "In most of the patients studied, ambulatory conservative management was safe and effective in the treatment of uncomplicated acute diverticulitis." | 2.74 | [Safety and efficiency of ambulatory treatment of acute diverticulitis]. ( García Marín, A; Martín Gil, J; Pérez Díaz, MD; Rey Valcárcel, C; Sanz Sánchez, M; Serralta De Colsa, D; Turégano Fuentes, F; Vaquero Rodríguez, A, 2009) |
| "Metronidazole (M) has potent bactericidal activity against anaerobic bacteria." | 2.65 | Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection. ( , 1983) |
| " After routine blood test and dosage of C-reactive protein (C-RP), patients were randomly divided into two groups: Probiotic group (42 patients, 10M/32F mean age 32." | 1.51 | The efficacy of a mix of three probiotic strains in reducing abdominal pain and inflammatory biomarkers in acute uncomplicated diverticulitis. ( Brigida, M; Franceschi, F; Marannino, M; Migneco, A; Ojetti, V; Petruzziello, C; Piccioni, A; Saviano, A, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Petruzziello, C | 1 |
| Marannino, M | 1 |
| Migneco, A | 1 |
| Brigida, M | 1 |
| Saviano, A | 1 |
| Piccioni, A | 1 |
| Franceschi, F | 1 |
| Ojetti, V | 1 |
| Gaber, CE | 1 |
| Kinlaw, AC | 1 |
| Edwards, JK | 1 |
| Lund, JL | 1 |
| Stürmer, T | 1 |
| Peacock Hinton, S | 1 |
| Pate, V | 1 |
| Bartelt, LA | 1 |
| Sandler, RS | 1 |
| Peery, AF | 1 |
| Briongos-Figuero, LS | 1 |
| Bachiller-Luque, P | 1 |
| Pastor-Mancisidor, L | 1 |
| Carreres-Rodríguez, A | 1 |
| Mena-Martín, FJ | 1 |
| Moya, P | 2 |
| Bellon, M | 1 |
| Arroyo, A | 2 |
| Galindo, I | 1 |
| Candela, F | 2 |
| Lacueva, J | 1 |
| Calpena, R | 2 |
| Leodolter, A | 1 |
| Zielinski, D | 1 |
| Borkenstein, D | 1 |
| Crone, M | 1 |
| Labenz, J | 1 |
| Ridgway, PF | 1 |
| Latif, A | 1 |
| Shabbir, J | 1 |
| Ofriokuma, F | 1 |
| Hurley, MJ | 1 |
| Evoy, D | 1 |
| O'Mahony, JB | 1 |
| Mealy, K | 1 |
| Wild, JR | 1 |
| Shiwani, MH | 1 |
| Ullah, Q | 1 |
| Martín Gil, J | 1 |
| Serralta De Colsa, D | 1 |
| García Marín, A | 1 |
| Vaquero Rodríguez, A | 1 |
| Rey Valcárcel, C | 1 |
| Pérez Díaz, MD | 1 |
| Sanz Sánchez, M | 1 |
| Turégano Fuentes, F | 1 |
| Alonso, S | 1 |
| Pera, M | 2 |
| Parés, D | 2 |
| Pascual, M | 1 |
| Gil, MJ | 2 |
| Courtier, R | 2 |
| Grande, L | 1 |
| Pérez-Legaz, J | 1 |
| Serrano, P | 1 |
| Soriano-Irigaray, L | 1 |
| Flint, R | 1 |
| Peláez, N | 1 |
| Sánchez, J | 1 |
| Grandea, L | 1 |
| Raina, A | 1 |
| Kiss, L | 1 |
| Yadav, D | 1 |
| Biron, S | 1 |
| Brochu, G | 1 |
| Béland, L | 1 |
| Bourque, RA | 1 |
| Marceau, P | 1 |
| Piché, P | 1 |
| Potvin, M | 1 |
| David, J | 1 |
| Ozick, LA | 1 |
| Schapira, D | 1 |
| Nachtigal, A | 1 |
| Scharf, Y | 1 |
| Hilmer, R | 1 |
| Goulston, K | 1 |
| Mendel, V | 1 |
| Jung, D | 1 |
| Heymann, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090] | 134 participants (Actual) | Interventional | 2018-04-16 | Completed | |||
| Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics[NCT02785549] | Phase 4 | 480 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for metronidazole and Diverticulitis
| Article | Year |
|---|---|
Randomized controlled trial of oral vs intravenous therapy for the clinically diagnosed acute uncomplicated diverticulitis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; C-Reactive Protein; Ciprofloxacin; Diverticuli | 2009 |
[Safety and efficiency of ambulatory treatment of acute diverticulitis].
Topics: Abdominal Pain; Abscess; Acute Disease; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ambulatory C | 2009 |
Outpatient treatment of patients with uncomplicated acute diverticulitis.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Care; Amoxicillin-Po | 2010 |
Short-term antibiotherapy for peritonitis: prospective, randomized trial comparing cefotaxime-metronidazole and clindamycin-tobramycin.
Topics: Cefotaxime; Clindamycin; Clinical Trials as Topic; Diverticulitis; Drug Combinations; Humans; Metron | 1984 |
Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection.
Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendicitis; Bacterial Infections | 1983 |
Single-shot antibiotic prophylaxis in colon surgery.
Topics: Bacteria; Ceftizoxime; Clinical Trials as Topic; Colonic Neoplasms; Diverticulitis; Humans; Metronid | 1987 |
13 other studies available for metronidazole and Diverticulitis
| Article | Year |
|---|---|
The efficacy of a mix of three probiotic strains in reducing abdominal pain and inflammatory biomarkers in acute uncomplicated diverticulitis.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Bifidobacterium animalis; C-Reactive Protein; Case-Cont | 2019 |
Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis : Two Nationwide Cohort Studies.
Topics: Adolescent; Adult; Ambulatory Care; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Ag | 2021 |
[Cerebellar syndrome induced by metronidazole: a rare side effect].
Topics: Anti-Bacterial Agents; Brain Abscess; Cefotaxime; Cephalosporins; Cerebellar Ataxia; Diagnosis, Diff | 2016 |
Outpatient treatment in uncomplicated acute diverticulitis: 5-year experience.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Ambulatory Care; Analgesics, Non-Narco | 2016 |
Diagnosis of jejunal diverticulitis by oral single-balloon enteroscopy.
Topics: Anti-Infective Agents; Catheterization; Ciprofloxacin; Diverticulitis; Drug Therapy, Combination; En | 2008 |
Jejunal diverticulitis.
Topics: Aged; Anti-Infective Agents; Cefuroxime; Diagnosis, Differential; Diverticulitis; Fluid Therapy; Hum | 2009 |
Applicability, safety and efficiency of outpatient treatment in uncomplicated diverticulitis.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anti-Infective Agents | 2012 |
Appendiceal diverticulitis and actinomycosis.
Topics: Actinomycosis; Adult; Anti-Infective Agents; Appendicitis; Cefuroxime; Diagnosis, Differential; Dive | 2002 |
[Applicability, safety and efficacy of an ambulatory treatment protocol in patients with uncomplicated acute diverticulitis].
Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Care; Amoxicillin-Po | 2006 |
Electronic clinical challenges and images in GI. Ileal diverticulitis.
Topics: Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Digestive System Surgical Procedures; Diver | 2008 |
Diverticulitis.
Topics: Aged; Barium Sulfate; Clindamycin; Diverticulitis; Drug Therapy, Combination; Enema; Humans; Male; M | 1995 |
Arthritis as the presenting symptom of diverticulitis.
Topics: Arthritis; Colonic Diseases; Colonoscopy; Diagnosis, Differential; Disease-Free Survival; Diverticul | 1997 |
Drugs used in treatment of large bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antidiarrheals; Azathioprine; Cathartics; Colitis, U | 1979 |