metronidazole has been researched along with Hemorrhage, Peptic Ulcer in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " pylori alone with the present bismuth-based triple therapy in patients with duodenal ulcer hemorrhage did not result in significant reduction in further bleeding episodes, although a trend was seen for the group that was given triple therapy." | 5.09 | Treatment of Helicobacter pylori in patients with duodenal ulcer hemorrhage--a long-term randomized, controlled study. ( Ching, CK; Hu, WH; Hui, WM; Lai, KC; Lam, SK; Wong, BC; Wong, WM, 2000) |
| "Cure of HP infection reduces the recurrence of peptic ulcer and of rebleeding from ulcer disease more effectively than does long-term maintenance therapy." | 2.68 | Antimicrobial therapy for Helicobacter pylori infection versus long-term maintenance antisecretion treatment in the prevention of recurrent hemorrhage from peptic ulcer: prospective nonrandomized trial on 125 patients. ( Cantero, J; Gómez-Cedenilla, A; Grávalos, RG; Pajares, JM; Santander, C, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ngom, G | 1 |
| Diouf, ML | 1 |
| Fall, M | 1 |
| Konaté, I | 1 |
| Sankalé, AA | 1 |
| Diop, M | 1 |
| Fall, I | 1 |
| Ndoye, M | 1 |
| Horvat, D | 1 |
| Vcev, A | 1 |
| Soldo, I | 1 |
| Timarac, J | 1 |
| Dmitrović, B | 1 |
| Misević, T | 1 |
| Ivezić, Z | 1 |
| Kraljik, N | 1 |
| Labenz, J | 1 |
| Börsch, G | 1 |
| Gisbert, JP | 1 |
| Boixeda, D | 1 |
| Hernández Ranz, F | 1 |
| Martín de Argila, C | 1 |
| Santander, C | 1 |
| Grávalos, RG | 1 |
| Gómez-Cedenilla, A | 1 |
| Cantero, J | 1 |
| Pajares, JM | 1 |
| Sheu, BS | 1 |
| Yang, HB | 1 |
| Su, IJ | 1 |
| Shiesh, SC | 1 |
| Chi, CH | 1 |
| Lin, XZ | 1 |
| Kung, NN | 1 |
| Sung, JJ | 3 |
| Yuen, NW | 1 |
| Ng, PW | 1 |
| Wong, KC | 1 |
| Chung, EC | 1 |
| Lim, BH | 1 |
| Choi, CH | 1 |
| Li, TH | 1 |
| Ma, HC | 1 |
| Kwok, SP | 1 |
| Leung, WK | 2 |
| Suen, R | 2 |
| Leung, VK | 1 |
| Chan, FK | 2 |
| Ling, TK | 1 |
| Lau, JY | 2 |
| Lee, YT | 2 |
| Ng, EK | 2 |
| Cheng, AF | 1 |
| Chung, SC | 2 |
| Wu, JC | 1 |
| Chan, HL | 1 |
| Lai, AC | 1 |
| Lai, KC | 1 |
| Hui, WM | 1 |
| Wong, WM | 1 |
| Wong, BC | 1 |
| Hu, WH | 1 |
| Ching, CK | 1 |
| Lam, SK | 1 |
| Sharma, VK | 1 |
| Sahai, AV | 1 |
| Corder, FA | 1 |
| Howden, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase IV Study Comparing Helicobacter Pylori Empiric Eradication With Test-Guided Treatment in Patients With Peptic Ulcer Bleeding[NCT00687336] | Phase 4 | 178 participants (Anticipated) | Interventional | 2008-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
Helicobacter pylori eradication is superior to ulcer healing with or without maintenance therapy to prevent further ulcer haemorrhage.
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Drug Therapy, Combination; Helicobacter Infection | 2001 |
6 trials available for metronidazole and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
The results of Helicobacter pylori eradication on repeated bleeding in patients with stomach ulcer.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Drug Administration Sc | 2005 |
Antimicrobial therapy for Helicobacter pylori infection versus long-term maintenance antisecretion treatment in the prevention of recurrent hemorrhage from peptic ulcer: prospective nonrandomized trial on 125 patients.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; Du | 1996 |
Anti-Helicobacter pylori treatment in bleeding ulcers: randomized controlled trial comparing 2-day versus 7-day bismuth quadruple therapy.
Topics: Activities of Daily Living; Adult; Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Drug Adm | 1997 |
One-week antibiotics versus maintenance acid suppression therapy for Helicobacter pylori-associated peptic ulcer bleeding.
Topics: Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Drug Therapy, Combination; Female; Helicob | 1997 |
Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Drug Therapy, Combination; | 1998 |
Treatment of Helicobacter pylori in patients with duodenal ulcer hemorrhage--a long-term randomized, controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Antacids; Anti-Bacterial Agents; Bismuth; D | 2000 |
4 other studies available for metronidazole and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
[Perforation and haemorrhage duodenal bulbar ulcers in a child: a case report].
Topics: Adrenergic Agonists; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child; Drug Therapy, | 2008 |
Role of Helicobacter pylori eradication in the prevention of peptic ulcer bleeding relapse.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Bismuth; Drug Therapy, Combination; Duodenal Ulcer; Fem | 1994 |
[Eradication of Helicobacter pylori and hemorrhagic recurrence of duodenal ulcer].
Topics: Antacids; Anti-Bacterial Agents; Bismuth; Duodenal Ulcer; Follow-Up Studies; Helicobacter Infections | 1995 |
Bacterial density of Helicobacter pylori predicts the success of triple therapy in bleeding duodenal ulcer.
Topics: Adult; Amoxicillin; Anti-Ulcer Agents; Biopsy; Drug Therapy, Combination; Duodenal Ulcer; Female; Ga | 1996 |