metronidazole has been researched along with Bacterial Eye Infections in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anterior necrotizing scleritis is a rare but potentially devastating complication of ocular surgery that most often occurs after cataract surgery in elderly patients who may have an underlying systemic autoimmune condition(1) or, less likely, an infectious cause." | 1.34 | Anterior necrotizing scleritis after strabismus surgery in a child. ( Blaikie, AJ; Gole, GA; Kearney, FM, 2007) |
| "Bacterial orbital cellulitis is an infection of the soft tissues behind the orbital septum." | 1.31 | The role of technetium-99m-HMPAO-labeled WBC scintigraphy in the diagnosis of orbital cellulitis. ( Ada, E; Capa, G; Durak, H; Durak, I; Sayit, E; Söylev, M; Yilmaz, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pushker, N | 1 |
| Tejwani, LK | 1 |
| Bajaj, MS | 1 |
| Khurana, S | 1 |
| Velpandian, T | 1 |
| Chandra, M | 1 |
| Pollett, S | 1 |
| McMullan, B | 1 |
| Lam, VW | 1 |
| Qureshi, C | 1 |
| Kok, J | 1 |
| Shams, PN | 1 |
| Policeni, B | 1 |
| Carter, KD | 1 |
| Shriver, E | 1 |
| Thurtell, MJ | 1 |
| Hazarika, M | 1 |
| Pai H, V | 1 |
| Khanna, V | 1 |
| Reddy, H | 1 |
| Tilak, K | 1 |
| Chawla, K | 1 |
| Chheda, LV | 1 |
| Sobol, WM | 1 |
| Buerk, BM | 1 |
| Kurz, PA | 1 |
| Knežević, M | 1 |
| Rašić, D | 1 |
| Stojković, M | 1 |
| Jovanović, M | 1 |
| Božić, M | 1 |
| Kearney, FM | 1 |
| Blaikie, AJ | 1 |
| Gole, GA | 1 |
| Starska, K | 1 |
| Lukomski, M | 1 |
| Starska-Dawidowskda, D | 1 |
| Sayit, E | 1 |
| Söylev, M | 1 |
| Capa, G | 1 |
| Durak, I | 1 |
| Ada, E | 1 |
| Yilmaz, M | 1 |
| Durak, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Corticosteroids in Children Hospitalized With Cellulitis: Randomized, Double Blind, Placebo Controlled Trial[NCT02087527] | 19 participants (Actual) | Interventional | 2014-06-30 | Terminated (stopped due to Calculated sample size not achieved) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Bacterial Eye Infections
| Article | Year |
|---|---|
Acute post-surgical bilateral orbital gas-producing infection - a case report and literature review.
Topics: Acute Disease; Anti-Bacterial Agents; Drug Therapy, Combination; Emphysema; Eye Infections, Bacteria | 2012 |
[Preseptal orbital abscess as a post-traumatic late complication--review of the literature and case report].
Topics: Abscess; Cephalosporins; Craniocerebral Trauma; Dacryocystitis; Eye Infections, Bacterial; Humans; M | 2007 |
1 trial available for metronidazole and Bacterial Eye Infections
| Article | Year |
|---|---|
Role of oral corticosteroids in orbital cellulitis.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Ceftriaxone; Child; Drug Therapy, Co | 2013 |
6 other studies available for metronidazole and Bacterial Eye Infections
| Article | Year |
|---|---|
A 68-year-old type 2 diabetic man of Korean ethnicity with fever, abdominal pain, and right eye visual disturbance.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Bacteremia; Diabetes Mellitus, Type 2; Endophthalmitis; | 2015 |
Bilateral septic cavernous sinus thrombosis, congestive orbitopathy, and ischemic optic neuropathy.
Topics: Aged; Anti-Infective Agents; Anticoagulants; Bacteremia; Cavernous Sinus Thrombosis; Drug Therapy, C | 2016 |
Rare Case of Polymicrobial Keratitis With Balantidium coli.
Topics: Anti-Bacterial Agents; Antiprotozoal Agents; Balantidiasis; Balantidium; Coinfection; Contact Lenses | 2016 |
Endogenous endophthalmitis with brain abscesses caused by Streptococcus constellatus.
Topics: Anti-Bacterial Agents; Brain Abscess; Ceftriaxone; Drug Therapy, Combination; Endophthalmitis; Eye I | 2011 |
Anterior necrotizing scleritis after strabismus surgery in a child.
Topics: Animals; Antiprotozoal Agents; Chloramphenicol; Drug Therapy, Combination; Dysentery, Amebic; Entamo | 2007 |
The role of technetium-99m-HMPAO-labeled WBC scintigraphy in the diagnosis of orbital cellulitis.
Topics: Cefotaxime; Cellulitis; Eye Infections, Bacterial; Female; Humans; Leukocytes; Magnetic Resonance Im | 2001 |