metronidazole has been researched along with HPV Infection in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Palma, E | 1 |
| Recine, N | 1 |
| Domenici, L | 1 |
| Giorgini, M | 1 |
| Pierangeli, A | 1 |
| Panici, PB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Lactobacilli Implementation to Restore a Balanced Vaginal Ecosystem: a Promising Solution Against Vaginosis, Vaginitis and HPV Infection[NCT03372395] | Phase 2 | 117 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Probiotics Role in HPV Clearance When Coexisting Vaginal Infections[NCT05109533] | 483 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and HPV Infection
| Article | Year |
|---|---|
Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection.
Topics: Administration, Intravaginal; Adult; Female; Fluconazole; Humans; Lacticaseibacillus rhamnosus; Metr | 2018 |
Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection.
Topics: Administration, Intravaginal; Adult; Female; Fluconazole; Humans; Lacticaseibacillus rhamnosus; Metr | 2018 |
Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection.
Topics: Administration, Intravaginal; Adult; Female; Fluconazole; Humans; Lacticaseibacillus rhamnosus; Metr | 2018 |
Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection.
Topics: Administration, Intravaginal; Adult; Female; Fluconazole; Humans; Lacticaseibacillus rhamnosus; Metr | 2018 |
1 other study available for metronidazole and HPV Infection
| Article | Year |
|---|---|
Drugs for sexually transmitted infections.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antitrichomonal Agents; Azithromycin; Chlamydia | 1999 |