metronidazole has been researched along with Coagulation, Disseminated Intravascular in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "24 days after the onset of infectious mononucleosis, clinically and serologically confirmed, an otherwise healthy 18-year-old schoolboy developed a fulminant septicaemia with acute meningitis and loss of consciousness, consumptive coagulopathy and acute renal failure." | 1.29 | [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. ( Busch, N; Haase, G; Kierdorf, H; Marschall, HU; Matern, S; Mertens, PR; Nguyen, H; Schönfelder, T; Sieberth, HG; Urhahn, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jensen, SL | 1 |
| Amato, JE | 1 |
| Hartstein, ME | 1 |
| Breer, WA | 1 |
| Georgopoulos, S | 1 |
| Korres, S | 1 |
| Riga, M | 1 |
| Balatsouras, D | 1 |
| Kotsis, G | 1 |
| Ferekidis, E | 1 |
| Busch, N | 1 |
| Mertens, PR | 1 |
| Schönfelder, T | 1 |
| Nguyen, H | 1 |
| Marschall, HU | 1 |
| Kierdorf, H | 1 |
| Haase, G | 1 |
| Urhahn, R | 1 |
| Sieberth, HG | 1 |
| Matern, S | 1 |
3 other studies available for metronidazole and Coagulation, Disseminated Intravascular
| Article | Year |
|---|---|
Bilateral periorbital necrotizing fasciitis.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacteremia; Bronchopneumonia; Ceftriaxone; Debri | 2004 |
Lemierre's syndrome associated with consumption coagulopathy and acute renal failure: a case report.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Disseminated Intravascular Coagulation; Drug Ther | 2008 |
[Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis].
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Disseminated In | 1996 |